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Protein

Zinc finger protein 658B

Gene

ZNF658B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16626C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri614 – 63623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri642 – 66423C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri670 – 69223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri698 – 72023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri726 – 74823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri754 – 77623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri782 – 80524C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 658B
Gene namesi
Name:ZNF658B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32033. ZNF658B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74753581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 819819Zinc finger protein 658BPRO_0000280434Add
BLAST

Proteomic databases

EPDiQ4V348.
PaxDbiQ4V348.
PRIDEiQ4V348.

PTM databases

PhosphoSiteiQ4V348.

Expressioni

Gene expression databases

CleanExiHS_ZNF658B.

Organism-specific databases

HPAiHPA047730.
HPA048668.

Interactioni

Protein-protein interaction databases

IntActiQ4V348. 1 interaction.
MINTiMINT-7302765.
STRINGi9606.ENSP00000366853.

Structurei

3D structure databases

ProteinModelPortaliQ4V348.
SMRiQ4V348. Positions 13-811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 21 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri141 – 16626C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri278 – 30023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 32823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri334 – 35623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri362 – 38423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri390 – 41223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri418 – 44023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri446 – 46823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri614 – 63623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri642 – 66423C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri670 – 69223C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri698 – 72023C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri726 – 74823C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri754 – 77623C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri782 – 80524C2H2-type 21PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ4V348.
PhylomeDBiQ4V348.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 20 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4V348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNLEKNFDK TTLFNHMRTD KRGKCSDLNE YGTSCDKTTA VEYNKVHMAM
60 70 80 90 100
THYECNERGI NFSRKSPLTQ SQRTITGWSA FESNKCEENF SQSSAHIVHQ
110 120 130 140 150
KTQAGDKFGE HNECTDALYQ KLDFTAHQRI HTDFTAHQKF YLSDEHGKCR
160 170 180 190 200
KSFYWKAHLI QHERPHSGEK TYQYEECAKS FCSSSHPIQH PGTYVGFKLY
210 220 230 240 250
ECNECGKAFC QNSNLSKHLR IHTKEKPCDN NGCGRSYKSP LIGHQKTDAE
260 270 280 290 300
MELCGGSEYG KTSHLKGHQR ILMGEKPYEC IECGKTFSKT SHLRAHQRIH
310 320 330 340 350
TGEKPYECVE CEKTFSHKTH LSVHQRVHTG EKPYECNDCG KSFTYNSALR
360 370 380 390 400
AHQRIHTGEK PYECSDCEKT FAHNSALRAH HRIHTGEKPY ECNECGRSFA
410 420 430 440 450
HISVLKAHQR IHTREKPYEC NECGRSFTYN SALRAHQRIH TGRKPYECSD
460 470 480 490 500
CEKTFAHNSA LKIHQRIHTG EKPYKCNECE KTFAHNSALR AHQNIHTGEK
510 520 530 540 550
LYECSECGKT FFQKTRLSTH RRIHTGEKPY ECSKCGKTFS QKSYLSGHER
560 570 580 590 600
IHTGEKPYEC NVCGKTFVYK AALIVHQRIH TGEKPYECNE CGKTFSQRTH
610 620 630 640 650
LCAHQRIHTG EKPYECNECG KTFADNSALR AHHRIHTGEK PYECNDCGKT
660 670 680 690 700
FSKTSHLRAH LRTRSGEKPY ECSECGKTFS EKSYVSAHQR VHTGEKPYEC
710 720 730 740 750
NVCGKPFAHN STLRVHQRIH TGEKSYECND CGKTFSQKSH LSAHQRIHTG
760 770 780 790 800
EKPYECNECG KAFAQNSTLR VHQRIHTGEK PYECDECGKT FVRKAALRVH
810
HTRMHTREKT LACNGFGKS
Length:819
Mass (Da):94,331
Last modified:July 5, 2005 - v1
Checksum:i6C9E277A199E4C4B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti664 – 6641R → H in BAC04610 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095694 mRNA. Translation: BAC04610.1.
BX248098 Genomic DNA. Translation: CAI95420.1.
UniGeneiHs.449445.
Hs.730226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095694 mRNA. Translation: BAC04610.1.
BX248098 Genomic DNA. Translation: CAI95420.1.
UniGeneiHs.449445.
Hs.730226.

3D structure databases

ProteinModelPortaliQ4V348.
SMRiQ4V348. Positions 13-811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4V348. 1 interaction.
MINTiMINT-7302765.
STRINGi9606.ENSP00000366853.

PTM databases

PhosphoSiteiQ4V348.

Polymorphism and mutation databases

DMDMi74753581.

Proteomic databases

EPDiQ4V348.
PaxDbiQ4V348.
PRIDEiQ4V348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiZNF658B.
HGNCiHGNC:32033. ZNF658B.
HPAiHPA047730.
HPA048668.
neXtProtiNX_Q4V348.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ4V348.
PhylomeDBiQ4V348.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

PROiQ4V348.

Gene expression databases

CleanExiHS_ZNF658B.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 10 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 20 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 21 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZ658B_HUMAN
AccessioniPrimary (citable) accession number: Q4V348
Secondary accession number(s): Q8N946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: March 16, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.