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Protein

GRIP1-associated protein 1

Gene

GRIPAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP1-associated protein 1
Short name:
GRASP-1
Gene namesi
Name:GRIPAP1
Synonyms:KIAA1167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18706. GRIPAP1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • early endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38650.

Polymorphism and mutation databases

DMDMi74753569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000875812 – 841GRIP1-associated protein 1Add BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei668PhosphoserineBy similarity1
Modified residuei669PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei690PhosphoserineCombined sources1
Modified residuei691PhosphoserineBy similarity1
Modified residuei692PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei598 – 599Cleavage; by caspase-3By similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ4V328.
MaxQBiQ4V328.
PaxDbiQ4V328.
PeptideAtlasiQ4V328.
PRIDEiQ4V328.

PTM databases

iPTMnetiQ4V328.
PhosphoSitePlusiQ4V328.

Miscellaneous databases

PMAP-CutDBQ4V328.

Expressioni

Gene expression databases

BgeeiENSG00000068400.
ExpressionAtlasiQ4V328. baseline and differential.
GenevisibleiQ4V328. HS.

Organism-specific databases

HPAiHPA000282.
HPA000615.

Interactioni

Subunit structurei

Interacts with GRIP1, GRIP2 and AMPA receptors.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RAB4AP203383EBI-717919,EBI-722284

Protein-protein interaction databases

BioGridi121210. 18 interactors.
DIPiDIP-47299N.
IntActiQ4V328. 50 interactors.
MINTiMINT-1395880.
STRINGi9606.ENSP00000365624.

Structurei

3D structure databases

ProteinModelPortaliQ4V328.
SMRiQ4V328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 161Sequence analysisAdd BLAST158
Coiled coili208 – 641Sequence analysisAdd BLAST434
Coiled coili701 – 735Sequence analysisAdd BLAST35
Coiled coili785 – 814Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKP9. Eukaryota.
ENOG410YB89. LUCA.
HOVERGENiHBG080243.
InParanoidiQ4V328.
OrthoDBiEOG091G0AQ8.
PhylomeDBiQ4V328.
TreeFamiTF329006.

Family and domain databases

InterProiIPR026204. GRIPAP1.
[Graphical view]
PANTHERiPTHR18978. PTHR18978. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4V328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK
60 70 80 90 100
EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF
110 120 130 140 150
SKLCSQMEQL EQENQQLKEG AAGAGVAQAG PLVDGELLRL QAENTALQKN
160 170 180 190 200
VAALQERYGK EAGKFSAVSE GQGDPPGGPA PTVLAPMPLA EVELKWEMEK
210 220 230 240 250
EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE SFCRLQTEKE
260 270 280 290 300
TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ
310 320 330 340 350
GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT
360 370 380 390 400
AKTQELNMLR EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR
410 420 430 440 450
LLEQLQEIGQ EKEQLTQELQ EARKSAEKRK AMLDELAMET LQEKSQHKEE
460 470 480 490 500
LGAVRLRHEK EVLGVRARYE RELRELHEDK KRQEEELRGQ IREEKARTRE
510 520 530 540 550
LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ QEQEEALKQC
560 570 580 590 600
REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ
610 620 630 640 650
RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL
660 670 680 690 700
SEMNSPSRTQ TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP
710 720 730 740 750
AELSDEEVAE LFQRLAETQQ EKWMLEEKVK HLEVSSASMA EDLCRKSAII
760 770 780 790 800
ETYVMDSRID VSVAAGHTDR SGLGSVLRDL VKPGDENLRE MNKKLQNMLE
810 820 830 840
EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET S
Length:841
Mass (Da):95,990
Last modified:July 5, 2005 - v1
Checksum:i48877D04F6630213
GO
Isoform 2 (identifier: Q4V328-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-155: Missing.
     534-559: Missing.
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Note: No experimental confirmation available.
Show »
Length:625
Mass (Da):71,878
Checksum:iC79355243210C480
GO
Isoform 3 (identifier: Q4V328-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-152: EQENQQLKEG...ENTALQKNVA → MWSFGTGTLP...IHHIFLFYSP
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):68,188
Checksum:i51E9C3CE7EA5B184
GO
Isoform 4 (identifier: Q4V328-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-347: Missing.

Note: No experimental confirmation available.
Show »
Length:810
Mass (Da):92,738
Checksum:iBC469E1FADB93F74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti677R → G in CAB95949 (PubMed:10908365).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156991 – 110Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_015700103 – 155Missing in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_015701111 – 152EQENQ…QKNVA → MWSFGTGTLPPEGLKASSPS IRGMARDFRDHLIHHIFLFY SP in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_015702317 – 347Missing in isoform 4. CuratedAdd BLAST31
Alternative sequenceiVSP_015703534 – 559Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015704688 – 704SLSSS…PAELS → VRGKEEPTAPASLNPKI in isoform 2 and isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_015705705 – 841Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640704 mRNA. Translation: CAE45824.1.
BX647804 mRNA. Translation: CAI45985.1. Different termination.
BX530088, AF207550 Genomic DNA. Translation: CAI95784.1.
BX530088, AF207550 Genomic DNA. Translation: CAI95786.1.
BX530088, AF207550 Genomic DNA. Translation: CAI95787.1.
BC001522 mRNA. Translation: AAH01522.2.
BC101544 mRNA. Translation: AAI01545.1.
BC101546 mRNA. Translation: AAI01547.1.
AB032993 mRNA. Translation: BAA86481.1.
AJ297364 mRNA. Translation: CAB95949.1.
CCDSiCCDS35248.1. [Q4V328-1]
RefSeqiNP_064522.3. NM_020137.4. [Q4V328-1]
UniGeneiHs.109929.

Genome annotation databases

EnsembliENST00000376423; ENSP00000365606; ENSG00000068400.
GeneIDi56850.
KEGGihsa:56850.
UCSCiuc033ecr.2. human. [Q4V328-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640704 mRNA. Translation: CAE45824.1.
BX647804 mRNA. Translation: CAI45985.1. Different termination.
BX530088, AF207550 Genomic DNA. Translation: CAI95784.1.
BX530088, AF207550 Genomic DNA. Translation: CAI95786.1.
BX530088, AF207550 Genomic DNA. Translation: CAI95787.1.
BC001522 mRNA. Translation: AAH01522.2.
BC101544 mRNA. Translation: AAI01545.1.
BC101546 mRNA. Translation: AAI01547.1.
AB032993 mRNA. Translation: BAA86481.1.
AJ297364 mRNA. Translation: CAB95949.1.
CCDSiCCDS35248.1. [Q4V328-1]
RefSeqiNP_064522.3. NM_020137.4. [Q4V328-1]
UniGeneiHs.109929.

3D structure databases

ProteinModelPortaliQ4V328.
SMRiQ4V328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121210. 18 interactors.
DIPiDIP-47299N.
IntActiQ4V328. 50 interactors.
MINTiMINT-1395880.
STRINGi9606.ENSP00000365624.

PTM databases

iPTMnetiQ4V328.
PhosphoSitePlusiQ4V328.

Polymorphism and mutation databases

DMDMi74753569.

Proteomic databases

EPDiQ4V328.
MaxQBiQ4V328.
PaxDbiQ4V328.
PeptideAtlasiQ4V328.
PRIDEiQ4V328.

Protocols and materials databases

DNASUi56850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376423; ENSP00000365606; ENSG00000068400.
GeneIDi56850.
KEGGihsa:56850.
UCSCiuc033ecr.2. human. [Q4V328-1]

Organism-specific databases

CTDi56850.
GeneCardsiGRIPAP1.
HGNCiHGNC:18706. GRIPAP1.
HPAiHPA000282.
HPA000615.
MIMi300408. gene.
neXtProtiNX_Q4V328.
PharmGKBiPA38650.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKP9. Eukaryota.
ENOG410YB89. LUCA.
HOVERGENiHBG080243.
InParanoidiQ4V328.
OrthoDBiEOG091G0AQ8.
PhylomeDBiQ4V328.
TreeFamiTF329006.

Miscellaneous databases

ChiTaRSiGRIPAP1. human.
GeneWikiiGRIPAP1.
GenomeRNAii56850.
PMAP-CutDBQ4V328.
PROiQ4V328.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000068400.
ExpressionAtlasiQ4V328. baseline and differential.
GenevisibleiQ4V328. HS.

Family and domain databases

InterProiIPR026204. GRIPAP1.
[Graphical view]
PANTHERiPTHR18978. PTHR18978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRAP1_HUMAN
AccessioniPrimary (citable) accession number: Q4V328
Secondary accession number(s): A6NL78
, Q3MJ75, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.