Q4V328 (GRAP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GRIP1-associated protein 1
Short name=GRASP-1

Gene names

Name:	GRIPAP1
Synonyms:	KIAA1167

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	841 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with GRIP1, GRIP2 and AMPA receptors By similarity.
Subcellular location	Early endosome Ref.7.
Post-translational modification	Proteolytically cleaved by caspase-3 By similarity.
Miscellaneous	Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.

Ontologies

Keywords
Cellular component	Endosome
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4V328-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4V328-2)

The sequence of this isoform differs from the canonical sequence as follows:
     103-155: Missing.
     534-559: Missing.
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q4V328-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-152: EQENQQLKEG...ENTALQKNVA → MWSFGTGTLP...IHHIFLFYSP
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q4V328-4)

The sequence of this isoform differs from the canonical sequence as follows:
     317-347: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 841	841	GRIP1-associated protein 1		PRO_0000087581
Regions
	Coiled coil	4 – 161	158	Potential
	Coiled coil	208 – 641	434	Potential
	Coiled coil	701 – 735	35	Potential
	Coiled coil	785 – 814	30	Potential
Sites
	Site	598 – 599	2	Cleavage; by caspase-3 By similarity
Amino acid modifications
	Modified residue	655	1	Phosphoserine Ref.10 Ref.12
	Modified residue	666	1	Phosphoserine Ref.11
	Modified residue	669	1	Phosphoserine By similarity
	Modified residue	690	1	Phosphoserine Ref.11
	Modified residue	692	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	1 – 110	110	Missing in isoform 3.		VSP_015699
	Alternative sequence	103 – 155	53	Missing in isoform 2.		VSP_015700
	Alternative sequence	111 – 152	42	EQENQ…QKNVA → MWSFGTGTLPPEGLKASSPS IRGMARDFRDHLIHHIFLFY SP in isoform 3.		VSP_015701
	Alternative sequence	317 – 347	31	Missing in isoform 4.		VSP_015702
	Alternative sequence	534 – 559	26	Missing in isoform 2.		VSP_015703
	Alternative sequence	688 – 704	17	SLSSS…PAELS → VRGKEEPTAPASLNPKI in isoform 2 and isoform 3.		VSP_015704
	Alternative sequence	705 – 841	137	Missing in isoform 2 and isoform 3.		VSP_015705
Experimental info
	Sequence conflict	677	1	R → G in CAB95949. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 48877D04F6630213	FASTA	841	95,990
	10 20 30 40 50 60 MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK EFSKAQKALS 70 80 90 100 110 120 KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKLCSQMEQL EQENQQLKEG 130 140 150 160 170 180 AAGAGVAQAG PLVDGELLRL QAENTALQKN VAALQERYGK EAGKFSAVSE GQGDPPGGPA 190 200 210 220 230 240 PTVLAPMPLA EVELKWEMEK EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE 250 260 270 280 290 300 SFCRLQTEKE TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ 310 320 330 340 350 360 GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT AKTQELNMLR 370 380 390 400 410 420 EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR LLEQLQEIGQ EKEQLTQELQ 430 440 450 460 470 480 EARKSAEKRK AMLDELAMET LQEKSQHKEE LGAVRLRHEK EVLGVRARYE RELRELHEDK 490 500 510 520 530 540 KRQEEELRGQ IREEKARTRE LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ 550 560 570 580 590 600 QEQEEALKQC REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ 610 620 630 640 650 660 RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL SEMNSPSRTQ 670 680 690 700 710 720 TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP AELSDEEVAE LFQRLAETQQ 730 740 750 760 770 780 EKWMLEEKVK HLEVSSASMA EDLCRKSAII ETYVMDSRID VSVAAGHTDR SGLGSVLRDL 790 800 810 820 830 840 VKPGDENLRE MNKKLQNMLE EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET S
	Isoform 2 [UniParc]. Checksum: C79355243210C480	FASTA	625	71,878
	10 20 30 40 50 60 MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK EFSKAQKALS 70 80 90 100 110 120 KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKERYGKEAG KFSAVSEGQG 130 140 150 160 170 180 DPPGGPAPTV LAPMPLAEVE LKWEMEKEEK RLLWEQLQGL ESSKQAETSR LQEELAKLSE 190 200 210 220 230 240 KLKKKQESFC RLQTEKETLF NDSRNKIEEL QQRKEADHKA QLARTQKLQQ ELEAANQSLA 250 260 270 280 290 300 ELRDQRQGER LEHAAALRAL QDQVSIQSAD AQEQVEGLLA ENNALRTSLA ALEQIQTAKT 310 320 330 340 350 360 QELNMLREQT TGLAAELQQQ QAEYEDLMGQ KDDLNSQLQE SLRANSRLLE QLQEIGQEKE 370 380 390 400 410 420 QLTQELQEAR KSAEKRKAML DELAMETLQE KSQHKEELGA VRLRHEKEVL GVRARYEREL 430 440 450 460 470 480 RELHEDKKRQ EEELRGQIRE EKARTRELET LQQTVEELQA QVHSMDGAKG WFERRLKEAE 490 500 510 520 530 540 GKEEELQDVR DQLEQAQEER DCHLKTISSL KQEVKDTVDG QRILEKKGSA ALKDLKRQLH 550 560 570 580 590 600 LERKRADKLQ ERLQDILTNS KSRSGLEELV LSEMNSPSRT QTGDSSSISS FSYREILREK 610 620 ESSAVPARVR GKEEPTAPAS LNPKI
	Isoform 3 [UniParc]. Checksum: 51E9C3CE7EA5B184	FASTA	594	68,188
	10 20 30 40 50 60 MWSFGTGTLP PEGLKASSPS IRGMARDFRD HLIHHIFLFY SPALQERYGK EAGKFSAVSE 70 80 90 100 110 120 GQGDPPGGPA PTVLAPMPLA EVELKWEMEK EEKRLLWEQL QGLESSKQAE TSRLQEELAK 130 140 150 160 170 180 LSEKLKKKQE SFCRLQTEKE TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ 190 200 210 220 230 240 SLAELRDQRQ GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT 250 260 270 280 290 300 AKTQELNMLR EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR LLEQLQEIGQ 310 320 330 340 350 360 EKEQLTQELQ EARKSAEKRK AMLDELAMET LQEKSQHKEE LGAVRLRHEK EVLGVRARYE 370 380 390 400 410 420 RELRELHEDK KRQEEELRGQ IREEKARTRE LETLQQTVEE LQAQVHSMDG AKGWFERRLK 430 440 450 460 470 480 EAEESLQQQQ QEQEEALKQC REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK 490 500 510 520 530 540 QEVKDTVDGQ RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL 550 560 570 580 590 SEMNSPSRTQ TGDSSSISSF SYREILREKE SSAVPARVRG KEEPTAPASL NPKI
	Isoform 4 [UniParc]. Checksum: BC469E1FADB93F74	FASTA	810	92,738
	10 20 30 40 50 60 MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK EFSKAQKALS 70 80 90 100 110 120 KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKLCSQMEQL EQENQQLKEG 130 140 150 160 170 180 AAGAGVAQAG PLVDGELLRL QAENTALQKN VAALQERYGK EAGKFSAVSE GQGDPPGGPA 190 200 210 220 230 240 PTVLAPMPLA EVELKWEMEK EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE 250 260 270 280 290 300 SFCRLQTEKE TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ 310 320 330 340 350 360 GERLEHAAAL RALQDQIQTA KTQELNMLRE QTTGLAAELQ QQQAEYEDLM GQKDDLNSQL 370 380 390 400 410 420 QESLRANSRL LEQLQEIGQE KEQLTQELQE ARKSAEKRKA MLDELAMETL QEKSQHKEEL 430 440 450 460 470 480 GAVRLRHEKE VLGVRARYER ELRELHEDKK RQEEELRGQI REEKARTREL ETLQQTVEEL 490 500 510 520 530 540 QAQVHSMDGA KGWFERRLKE AEESLQQQQQ EQEEALKQCR EQHAAELKGK EEELQDVRDQ 550 560 570 580 590 600 LEQAQEERDC HLKTISSLKQ EVKDTVDGQR ILEKKGSAAL KDLKRQLHLE RKRADKLQER 610 620 630 640 650 660 LQDILTNSKS RSGLEELVLS EMNSPSRTQT GDSSSISSFS YREILREKES SAVPARSLSS 670 680 690 700 710 720 SPQAQPPRPA ELSDEEVAEL FQRLAETQQE KWMLEEKVKH LEVSSASMAE DLCRKSAIIE 730 740 750 760 770 780 TYVMDSRIDV SVAAGHTDRS GLGSVLRDLV KPGDENLREM NKKLQNMLEE QLTKNMHLHK 790 800 810 DMEVLSQEIV RLSKECVGPP DPDLEPGETS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Prostate and Retina.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 4).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Muscle.
[4]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-841 (ISOFORM 1). Tissue: Brain.
[5]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 401-412, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[6]	"By-passing selection: direct screening for antibody-antigen interactions using protein arrays." Holt L.J., Bussow K., Walter G., Tomlinson I.M. Nucleic Acids Res. 28:72-72(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 677-841. Tissue: Fetal brain.
[7]	"Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes." Stinton L.M., Selak S., Fritzler M.J. Clin. Immunol. 116:108-117(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, ROLE IN RAYNAUD SYNDROME.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-655, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-690 AND SER-692, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-655, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640704 mRNA. Translation: CAE45824.1. BX647804 mRNA. Translation: CAI45985.1. Different termination. BX530088, AF207550 Genomic DNA. Translation: CAI95784.1. BX530088, AF207550 Genomic DNA. Translation: CAI95786.1. BX530088, AF207550 Genomic DNA. Translation: CAI95787.1. BC001522 mRNA. Translation: AAH01522.2. BC101544 mRNA. Translation: AAI01545.1. BC101546 mRNA. Translation: AAI01547.1. AB032993 mRNA. Translation: BAA86481.1. AJ297364 mRNA. Translation: CAB95949.1.
IPI	IPI00414215. IPI00423384. IPI00607628. IPI00873904.
RefSeq	NP_064522.3. NM_020137.3. NP_997555.1. NM_207672.1.
UniGene	Hs.109929.
3D structure databases
ProteinModelPortal	Q4V328.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47299N.
IntAct	Q4V328. 3 interactions.
MINT	MINT-1395880.
PTM databases
PhosphoSite	Q4V328.
Polymorphism databases
DMDM	74753569.
Proteomic databases
PaxDb	Q4V328.
PRIDE	Q4V328.
Protocols and materials databases
DNASU	56850.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376423; ENSP00000365606; ENSG00000068400. ENST00000376425; ENSP00000365608; ENSG00000068400. ENST00000376441; ENSP00000365624; ENSG00000068400.
GeneID	56850.
KEGG	hsa:56850.
UCSC	uc004dly.1. human. uc004dlz.3. human. uc004dma.3. human.
Organism-specific databases
CTD	56850.
GeneCards	GC0XM048830.
HGNC	HGNC:18706. GRIPAP1.
HPA	HPA000282. HPA000615.
MIM	300408. gene.
neXtProt	NX_Q4V328.
PharmGKB	PA38650.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG135471.
HOVERGEN	HBG080243.
OMA	KHLEARA.
Gene expression databases
ArrayExpress	Q4V328.
Bgee	Q4V328.
Genevestigator	Q4V328.
GermOnline	ENSG00000068400. Homo sapiens.
Family and domain databases
InterPro	IPR026204. GRIPAP1. [Graphical view]
PANTHER	PTHR18978. PTHR18978. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	56850.
NextBio	62252.
PMAP-CutDB	Q4V328.
SOURCE	Search...

Entry information

Entry name

GRAP1_HUMAN

Accession

Primary (citable) accession number: Q4V328
Secondary accession number(s): A6NL78 , Q3MJ75, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	July 5, 2005
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.