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Protein

G antigen 2E

Gene

GAGE2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2E
Short name:
GAGE-2E
Gene namesi
Name:GAGE2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000275113.1
HGNCiHGNC:31960 GAGE2E
MIMi300736 gene
neXtProtiNX_Q4V326

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389276

Polymorphism and mutation databases

BioMutaiGAGE2E
DMDMi74753567

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954461 – 110G antigen 2EAdd BLAST110

Proteomic databases

EPDiQ4V326
MaxQBiQ4V326
PaxDbiQ4V326
PeptideAtlasiQ4V326
PRIDEiQ4V326

PTM databases

iPTMnetiQ4V326
PhosphoSitePlusiQ4V326

Expressioni

Gene expression databases

BgeeiENSG00000275113

Organism-specific databases

HPAiHPA043232

Interactioni

Protein-protein interaction databases

BioGridi117809, 2 interactors
STRINGi9606.ENSP00000384742

Structurei

3D structure databases

ProteinModelPortaliQ4V326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiQ4V326
OrthoDBiEOG091G0UGV
PhylomeDBiQ4V326
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE
Length:110
Mass (Da):12,217
Last modified:March 28, 2018 - v2
Checksum:i3D6336CFA9B6BBE8
GO

Sequence cautioni

The sequence CAI95421 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19Q → E in CAI95421 (PubMed:15772651).Curated1
Sequence conflicti75H → D in CAI95421 (PubMed:15772651).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649339 Genomic DNA Translation: CAI95421.1 Sequence problems.
AC233302 Genomic DNA No translation available.
UniGeneiHs.695912

Genome annotation databases

EnsembliENST00000621907; ENSP00000478568; ENSG00000275113

Similar proteinsi

Entry informationi

Entry nameiGAG2E_HUMAN
AccessioniPrimary (citable) accession number: Q4V326
Secondary accession number(s): A0A087WUD6, A6NFB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health