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Protein

G antigen 2E

Gene

GAGE2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 2E
Short name:
GAGE-2E
Gene namesi
Name:GAGE2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:31960. GAGE2E.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389276.

Polymorphism and mutation databases

BioMutaiGAGE2E.
DMDMi74753567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954461 – 116G antigen 2EAdd BLAST116

Proteomic databases

MaxQBiQ4V326.
PaxDbiQ4V326.
PeptideAtlasiQ4V326.
PRIDEiQ4V326.

PTM databases

iPTMnetiQ4V326.
PhosphoSitePlusiQ4V326.

Expressioni

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

BioGridi117809. 2 interactors.
STRINGi9606.ENSP00000384742.

Structurei

3D structure databases

ProteinModelPortaliQ4V326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ4V326.
PhylomeDBiQ4V326.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYR PRPRRYVEPP EMIGPMRPEQ FSDEVEPATP EEGEPATQRQ
60 70 80 90 100
DPAAAQEGED EGASAGQGPK PEADSQEQGH PQTGCECEDG PDGQEMDPPN
110
PEEVKTPEEG KKQSQC
Length:116
Mass (Da):12,763
Last modified:July 5, 2005 - v1
Checksum:iDD3052939E6ED19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649339 Genomic DNA. Translation: CAI95421.1.
UniGeneiHs.695912.

Similar proteinsi

Entry informationi

Entry nameiGAG2E_HUMAN
AccessioniPrimary (citable) accession number: Q4V326
Secondary accession number(s): A6NFB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 5, 2005
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families