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Protein

G antigen 13

Gene

GAGE13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 13
Short name:
GAGE-13
Alternative name(s):
G antigen 12A
Short name:
GAGE-12A
Gene namesi
Name:GAGE13
Synonyms:GAGE12A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29081. GAGE13.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiGAGE13.
DMDMi74753563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524761 – 117G antigen 13Add BLAST117

Proteomic databases

PaxDbiQ4V321.
PeptideAtlasiQ4V321.
PRIDEiQ4V321.

Expressioni

Gene expression databases

CleanExiHS_GAGE13.

Organism-specific databases

HPAiHPA043232.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371170.

Structurei

3D structure databases

ProteinModelPortaliQ4V321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC. Eukaryota.
ENOG4110Q8D. LUCA.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ4V321.
PhylomeDBiQ4V321.
TreeFamiTF340669.

Family and domain databases

InterProiView protein in InterPro
IPR031320. GAGE.
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.
PfamiView protein in Pfam
PF05831. GAGE. 1 hit.
SMARTiView protein in SMART
SM01379. GAGE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4V321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY RPRPRRYVEP PEMIGPMRPE QFSDEVEPAT PEEGEPATQC
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GKKQSQC
Length:117
Mass (Da):12,873
Last modified:July 5, 2005 - v1
Checksum:iD9377F101C2C6D9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649339, AF235097 Genomic DNA. Translation: CAI95426.1.

Similar proteinsi

Entry informationi

Entry nameiGAG13_HUMAN
AccessioniPrimary (citable) accession number: Q4V321
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2005
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families