Q4UZI9 (HGD_XANC8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homogentisate 1,2-dioxygenase
EC=1.13.11.5

Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Gene names

Name:	hmgA
Ordered Locus Names:	XC_0452

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas › Xanthomonas campestris › Xanthomonas campestris pv. campestris

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334		PRO_0000225796
Sites
	Metal binding	351	1	Iron By similarity
	Metal binding	357	1	Iron By similarity
	Metal binding	387	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UZI9 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 2225A12DAD492A23	FASTA	455	50,406
	10 20 30 40 50 60 MIQLDPTLLL SWRAGQHPDA PMHNDQRYMT GFGNEFASEA VADTLPVGQN SPQRVAHGLY 70 80 90 100 110 120 AEQLSGTAFT APRGENRRSW LYRMRPAAVH GTFSLIEQSQ FHNDFGHGPV PPDQLRWSPL 130 140 150 160 170 180 PLPQTPTDFI DGLYTMAGNG SPEAMNGVAV HLYAANASMQ DRFFYNADGE LLLVPQLGRL 190 200 210 220 230 240 RVHTELGMLE LEPQQIGVIP RGVRFRVELR DGTARGYVCE NFGGLLHLPD LGPIGSNGLA 250 260 270 280 290 300 NPRDFETPCA AFEQREGRFE LVAKFQGHLW RADIGHSPLD VVAWHGNYAP YRYDLRRFNT 310 320 330 340 350 360 IGSISFDHPD PSIFTVLTSP SDTHGTANMD FAIFPPRWLV AQHTFRPPWF HRNVASEFMG 370 380 390 400 410 420 LVHGVYDAKA DGFAPGGASL HNCMSGHGPD AATFDKASQA DLSRPDVITE TMAFMFETRA 430 440 450 VLRPTAQALH APHRQGDYQQ CWAGLRKAFQ APPAS

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8004.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000050 Genomic DNA. Translation: AAY47534.1.
RefSeq	YP_241554.1. NC_007086.1.
3D structure databases
ProteinModelPortal	Q4UZI9.
ModBase	Search...
Protein-protein interaction databases
STRING	314565.XC_0452.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY47534; AAY47534; XC_0452.
GeneID	3382101.
KEGG	xcb:XC_0452.
PATRIC	24062142. VBIXanCam24967_0482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HOG000139824.
KO	K00451.
OMA	AVTKWGL.
ProtClustDB	PRK05341.
Enzyme and pathway databases
UniPathway	UPA00139; UER00339.
Family and domain databases
Gene3D	2.60.120.10. 2 hits.
HAMAP	MF_00334. Homogentis_dioxygen.
InterPro	IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
PANTHER	PTHR11056. PTHR11056. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANC8

Accession

Primary (citable) accession number: Q4UZI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program