Reviewed,
UniProtKB/Swiss-Prot Q4UZI9 (HGD_XANC8)
Last modified
February 9, 2010.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisicase Homogentisate oxygenase Homogentisic acid oxidase | ||||
| Gene names |
| ||||
| Organism | Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 314565 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas |
Protein attributes
| Sequence length | 455 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334 |
| Cofactor | Iron By similarity. HAMAP MF_00334 |
| Pathway | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334 |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 455 | 455 | Homogentisate 1,2-dioxygenase HAMAP MF_00334 | PRO_0000225796 | |||||
Sites | |||||||||
| Metal binding | 351 | 1 | Iron By similarity | ||||||
| Metal binding | 357 | 1 | Iron By similarity | ||||||
| Metal binding | 387 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. He C.Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000050 Genomic DNA. Translation: AAY47534.1. |
| RefSeq | YP_241554.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q4UZI9. |
Genome annotation databases | |
| GeneID | 3382101. |
| GenomeReviews | Gene locus XC_0452 in contig CP000050_GR. |
| KEGG | xcb:XC_0452. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG3508. |
| HOGENOM | HBG293508. |
| OMA | RNCMSEF. |
Enzyme and pathway databases | |
| BioCyc | XCAM314565:XC_0452-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00334. Homogentis_dioxygen. [Tree] |
| InterPro | IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_XANC8 | ||||||||
| Accession | Primary (citable) accession number: Q4UZI9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


