Reviewed, UniProtKB/Swiss-Prot Q4UZI9 (HGD_XANC8)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	XC_0452

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Homogentisate 1,2-dioxygenase		PRO_0000225796
Sites
	Metal binding	351	1	Iron By similarity
	Metal binding	357	1	Iron By similarity
	Metal binding	387	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UZI9-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 2225A12DAD492A23	FASTA	455	50,406
	10 20 30 40 50 60 MIQLDPTLLL SWRAGQHPDA PMHNDQRYMT GFGNEFASEA VADTLPVGQN SPQRVAHGLY 70 80 90 100 110 120 AEQLSGTAFT APRGENRRSW LYRMRPAAVH GTFSLIEQSQ FHNDFGHGPV PPDQLRWSPL 130 140 150 160 170 180 PLPQTPTDFI DGLYTMAGNG SPEAMNGVAV HLYAANASMQ DRFFYNADGE LLLVPQLGRL 190 200 210 220 230 240 RVHTELGMLE LEPQQIGVIP RGVRFRVELR DGTARGYVCE NFGGLLHLPD LGPIGSNGLA 250 260 270 280 290 300 NPRDFETPCA AFEQREGRFE LVAKFQGHLW RADIGHSPLD VVAWHGNYAP YRYDLRRFNT 310 320 330 340 350 360 IGSISFDHPD PSIFTVLTSP SDTHGTANMD FAIFPPRWLV AQHTFRPPWF HRNVASEFMG 370 380 390 400 410 420 LVHGVYDAKA DGFAPGGASL HNCMSGHGPD AATFDKASQA DLSRPDVITE TMAFMFETRA 430 440 450 VLRPTAQALH APHRQGDYQQ CWAGLRKAFQ APPAS

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000050 Genomic DNA. Translation: AAY47534.1.
RefSeq	YP_241554.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3382101.
GenomeReviews	Gene locus XC_0452 in contig CP000050_GR.
KEGG	xcb:XC_0452.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UZI9.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_0452-MON.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANC8

Accession

Primary (citable) accession number: Q4UZI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2005
Last modified:	November 4, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)