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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

XC_0954

Organism
Xanthomonas campestris pv. campestris (strain 8004)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (XC_0954)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciXCAM314565:GCQG-952-MONOMER.
UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:XC_0954
OrganismiXanthomonas campestris pv. campestris (strain 8004)
Taxonomic identifieri314565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Probable 5-dehydro-4-deoxyglucarate dehydratasePRO_1000045414Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314565.XC_0954.

Structurei

3D structure databases

ProteinModelPortaliQ4UY45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiEOG6W7235.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UY45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRYTPSEM AQALGAGLLS FPVTHFDADM AFDEPAYRSN LDWLSSHPAA
60 70 80 90 100
GLFAAGGTGE LFSLTLDEVD RAVRAAVTQT AGRMPVIAPA GYGTAIAVAM
110 120 130 140 150
AQAAERNDAD GILLFPPYLT ECDADGVAEH VERVCKATSL GVIVYGRANA
160 170 180 190 200
RLDDVALARV AERCPNLMGY KDGIGDVDRM TRIYARLGDR LLYVGGLPTA
210 220 230 240 250
ETFALPYLEM GVTTYSSAIF NFLPEWALSF YAAVRARDHA TIYRELNDFV
260 270 280 290 300
LPYTVLRNRR AGYAVSIVKA GMRAVGRPAG PVRTPLADLT EDEFAQPTQL

IGGRR
Length:305
Mass (Da):32,937
Last modified:July 5, 2005 - v1
Checksum:iDF0351B200C89008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000050 Genomic DNA. Translation: AAY48028.1.
RefSeqiWP_011269541.1. NC_007086.1.

Genome annotation databases

EnsemblBacteriaiAAY48028; AAY48028; XC_0954.
KEGGixcb:XC_0954.
PATRICi24063245. VBIXanCam24967_1032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000050 Genomic DNA. Translation: AAY48028.1.
RefSeqiWP_011269541.1. NC_007086.1.

3D structure databases

ProteinModelPortaliQ4UY45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi314565.XC_0954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY48028; AAY48028; XC_0954.
KEGGixcb:XC_0954.
PATRICi24063245. VBIXanCam24967_1032.

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.
OrthoDBiEOG6W7235.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.
BioCyciXCAM314565:GCQG-952-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris."
    Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L.
    , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.
    Genome Res. 15:757-767(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 8004.

Entry informationi

Entry nameiKDGD_XANC8
AccessioniPrimary (citable) accession number: Q4UY45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.