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Q4UWK8

- SYL_XANC8

UniProt

Q4UWK8 - SYL_XANC8

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Protein
Leucine--tRNA ligase
Gene
leuS, XC_1497
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXCAM314565:GCQG-1495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:XC_1497
OrganismiXanthomonas campestris pv. campestris (strain 8004)
Taxonomic identifieri314565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000000420: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Leucine--tRNA ligaseUniRule annotation
PRO_0000334837Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314565.XC_1497.

Structurei

3D structure databases

ProteinModelPortaliQ4UWK8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi638 – 6425"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UWK8-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVEPNAYD PQQVETSAQQ FWDATRAFQV DENSDKPKFY CLSMLPYPSG    50
ALHMGHVRNY TISDVVSRYK RMTGHNVLQP MGWDAFGLPA ENAAIKNKTA 100
PAKWTYANIE HMRAQLKSLG YAIDWSREFA TCTPDYYVHE QRMFTRLMRK 150
GLAYRRNAVV NWDPIDQTVL ANEQVIDGRG WRSGALVEKR EIPQWFLRIT 200
DYAQELLDGL DQLDGWPDSV KTMQRNWIGR SEGLEIQFDV RDTTGAALDP 250
LRVFTTRPDT LMGVTFVSIA AEHPLAQHAA KSNPELASML ETLKHGGVSE 300
AELETQEKRG MATGLTAVHP ISGEEVPVWV ANFVLMGYGT GAVMAVPGHD 350
QRDFEFANKY GLPIVQVVKL REPRNDDEQA WDATQWRDWY TDKSRELELI 400
NSAEFDGLDY HGAFEALAER FERKGQGQRR INYRLRDWGV SRQRYWGCPI 450
PVIYCAKCGA VPVPEDQLPV VLPENVEFAG TGSPIKTDPT WRQTTCPECG 500
GPAERETDTF DTFMESSWYV ARYTSPNARD MVDRRANYWM PADLYVGGIE 550
HAILHLMYFR FYHKLMRDAR LVDSDEPVTN LLTQGMVIAE TFYRDADNGG 600
KDWINPADVE IQRDERGRVV GASLIADGQP VHIGGTEKMS KSKNNGVDPQ 650
AMVAKYGADT VRLFSMFAAP PEQSLEWNEA GVDGMARFMR RLWVQVHKHV 700
GEGAAALDVA SLSAEQKAIR RKTHETIGKV DDDYGRRHSF NTAIAAVMEL 750
SNALAKFDDA SAQGRAVRQE ALEAMVLLLN PITPHASHAL WQVLGRGETL 800
LENVPFPQVD AAALVRDALT LAIQVNGKLR GTIEVAADAA REQIEALALA 850
EPNAAKFLDG LSVRKIIIVP GKIVNIVAG 879
Length:879
Mass (Da):98,416
Last modified:May 20, 2008 - v2
Checksum:iF7E1CB145F1B4807
GO

Sequence cautioni

The sequence AAY48565.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000050 Genomic DNA. Translation: AAY48565.1. Different initiation.
RefSeqiYP_242585.1. NC_007086.1.

Genome annotation databases

EnsemblBacteriaiAAY48565; AAY48565; XC_1497.
GeneIDi3381840.
KEGGixcb:XC_1497.
PATRICi24064421. VBIXanCam24967_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000050 Genomic DNA. Translation: AAY48565.1 . Different initiation.
RefSeqi YP_242585.1. NC_007086.1.

3D structure databases

ProteinModelPortali Q4UWK8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 314565.XC_1497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY48565 ; AAY48565 ; XC_1497 .
GeneIDi 3381840.
KEGGi xcb:XC_1497.
PATRICi 24064421. VBIXanCam24967_1617.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XCAM314565:GCQG-1495-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris."
    Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L.
    , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.
    Genome Res. 15:757-767(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 8004.

Entry informationi

Entry nameiSYL_XANC8
AccessioniPrimary (citable) accession number: Q4UWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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