Q4UVL3 (GPH_XANC8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycolate phosphatase
Short name=PGP
Short name=PGPase
EC=3.1.3.18

Gene names

Ordered Locus Names:

XC_1847

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity. HAMAP MF_00495
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Pathway	Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. HAMAP MF_00495
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238183
Sites
	Active site	10	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UVL3 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: BFF0E5487F276B21	FASTA	221	24,075
	10 20 30 40 50 60 MRFPRAVLFD LDGTLLDSAP DMLATVNAML SERGLPCITL AQLRPVVSKG SRAMLAVAFA 70 80 90 100 110 120 HLDAAAREAL VPEFLKRYEA LLGTQAQLFD GVEVMLQRLE QAGCVWGIVT NKPEYLAQLI 130 140 150 160 170 180 LPQLGWQQRC AVLIGGDTLA ERKPHPLPLL VAADRIGVAA TQCVYVGDDE RDILAARAAG 190 200 210 220 MPSVAALWGY RLGDDDPLSW QADVLVEQPP QLWEPAAWPQ P

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8004.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000050 Genomic DNA. Translation: AAY48910.1.
RefSeq	YP_242930.1. NC_007086.1.
3D structure databases
ProteinModelPortal	Q4UVL3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4UVL3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3380394.
GenomeReviews	Gene locus XC_1847 in contig CP000050_GR.
KEGG	xcb:XC_1847.
PATRIC	24065175. VBIXanCam24967_1986.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0546.
HOGENOM	HBG742904.
OMA	CAVHSKL.
PhylomeDB	Q4UVL3.
ProtClustDB	PRK13226.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_1847-MONOMER.
Family and domain databases
HAMAP	MF_00495. GPH_hydrolase_bact. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR005833. Haloacid_DH/epoxide_hydro. IPR006346. PGP_bact. IPR023198. PGP_dom2. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits. G3DSA:1.10.150.240. PGP_dom2. 1 hit.
KO	K01091.
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_XANC8

Accession

Primary (citable) accession number: Q4UVL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program