Reviewed, UniProtKB/Swiss-Prot Q4UT95 (3HAO_XANC8)

Names and originHide

Protein names

Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6

Alternative name(s):
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
3-hydroxyanthranilate oxygenase
Short name=3-HAO

Gene names

Ordered Locus Names:

XC_2679

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributesHide

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)Hide

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP MF_00825
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825
Cofactor	Binds 2 Fe2+ ions per subunit By similarity. HAMAP MF_00825
Subunit structure	Homodimer By similarity. HAMAP MF_00825
Sequence similarities	Belongs to the 3-HAO family.

OntologiesHide

Keywords
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: HAMAP ferrous iron binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)Hide

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	3-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825		PRO_0000245481
Sites
	Metal binding	48	1	Iron 1; catalytic By similarity
	Metal binding	54	1	Iron 1; catalytic By similarity
	Metal binding	92	1	Iron 1; catalytic By similarity
	Metal binding	121	1	Iron 2 By similarity
	Metal binding	124	1	Iron 2 By similarity
	Metal binding	158	1	Iron 2 By similarity
	Metal binding	161	1	Iron 2 By similarity
	Binding site	44	1	Dioxygen By similarity
	Binding site	54	1	Substrate By similarity
	Binding site	96	1	Substrate By similarity
	Binding site	106	1	Substrate By similarity

SequencesHide

	Sequence		Length	Mass (Da)
	Q4UT95-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 3C2FDD218C8458D4	FASTA	176	20,128
	10 20 30 40 50 60 MLVPPINLHA WVEQHRHLLK PPVGNKCIQQ DGFIIMIVGG PNARTDYHYD EGPEWFFQLE 70 80 90 100 110 120 GEMVLKVQDD GTARDIPIRA GEIFLLPPKV PHSPQRAAGS IGLVIERERL PHEQDGLQWY 130 140 150 160 170 CPQCNHKLYE AMFPLENIET DFPPVFDHFY RSLALRTCTQ CGHVHPAPER YAAVEA

ReferencesHide

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-referencesHide

Sequence databases
EMBL GenBank DDBJ	CP000050 Genomic DNA. Translation: AAY49728.1.
RefSeq	YP_243748.1.
3D structure databases
SMR	Q4UT95. Positions 2-168.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4UT95.
Genome annotation databases
GeneID	3381213.
GenomeReviews	Gene locus XC_2679 in contig CP000050_GR.
KEGG	xcb:XC_2679.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG77058.
HOGENOM	HBG341987.
OMA	LKPPVNN.
PhylomeDB	Q4UT95.
ProtClustDB	PRK13264.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_2679-MONOMER.
Family and domain databases
HAMAP	MF_00825. 3_HAO. [Tree]
InterPro	IPR010329. 3hydroanth_dOase. IPR011051. Cupin_RmlC_type. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry informationHide

Entry name

3HAO_XANC8

Accession

Primary (citable) accession number: Q4UT95

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2005
Last modified:	July 13, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)