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Q4UT92 (KMO_XANC8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9
Alternative name(s):
Kynurenine 3-hydroxylase
Gene names
Name:kmo
Ordered Locus Names:XC_2682
OrganismXanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]
Taxonomic identifier314565 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.

Catalytic activity

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.

Cofactor

FAD By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandFAD
Flavoprotein
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionkynurenine 3-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Kynurenine 3-monooxygenase
PRO_0000361948

Sequences

Sequence LengthMass (Da)Tools
Q4UT92 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 265B933209C490EA

FASTA45650,945
        10         20         30         40         50         60 
MSAAASPRSL TLIGAGLAGC LLAILLSRRG WQITLYERRG DPRIKGYESG RSINLALAER 

        70         80         90        100        110        120 
GRHALRQAGA EDAVMAKAVM MRGRMIHPVS GEPQLQRYGR DDSEVIWSIH RAALNVTLLD 

       130        140        150        160        170        180 
LAEQAGARVH FYRRLHTVDF DAGYARFIDD RDDQPHEIHF QALVGSDGAG SALRAAMQRK 

       190        200        210        220        230        240 
APVGEHIAFL DHSYKELEIP PRADGGFRIE RNALHIWPRG RYMCIALPND GGTFTVTLFL 

       250        260        270        280        290        300 
PNEGMPSFAT TRSGDEALAL FARDFPDALP LIPQLKEHWE EHPPGLLGTL TRERWHLDGR 

       310        320        330        340        350        360 
AVLLGDAAHA MVPFHGQGMN CAFEDCVALA EQLDAHSDLS EAFAAFEAAR RDDAAAIQQM 

       370        380        390        400        410        420 
ALENYLEMRD RVGDAQFLLQ RALEQQLQAR WPTRFVPHYT MVTFLRTRYA IALARSEIQR 

       430        440        450 
EILLEATHGH TDLSRIDWVA LETVVHARLE PLEGAH

« Hide

References

[1]"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris."
Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. expand/collapse author list , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.
Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8004.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000050 Genomic DNA. Translation: AAY49731.1.
RefSeqYP_243751.1. NC_007086.1.

3D structure databases

ProteinModelPortalQ4UT92.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4UT92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3381216.
GenomeReviewsGene locus XC_2682 in contig CP000050_GR.
KEGGxcb:XC_2682.
PATRIC24066925. VBIXanCam24967_2843.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0654.
HOGENOMHBG430104.
OMAYFPDAIP.
PhylomeDBQ4UT92.
ProtClustDBCLSK903475.

Enzyme and pathway databases

BioCycXCAM314565:XC_2682-MONOMER.

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
KOK00486.
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Entry information

Entry nameKMO_XANC8
AccessionPrimary (citable) accession number: Q4UT92
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 5, 2005
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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