Reviewed, UniProtKB/Swiss-Prot Q4UT92 (KMO_XANC8)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	XC_2682

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	456 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 456	456	Kynurenine 3-monooxygenase		PRO_0000361948

Sequences

	Sequence		Length	Mass (Da)
	Q4UT92-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 265B933209C490EA	FASTA	456	50,945
	10 20 30 40 50 60 MSAAASPRSL TLIGAGLAGC LLAILLSRRG WQITLYERRG DPRIKGYESG RSINLALAER 70 80 90 100 110 120 GRHALRQAGA EDAVMAKAVM MRGRMIHPVS GEPQLQRYGR DDSEVIWSIH RAALNVTLLD 130 140 150 160 170 180 LAEQAGARVH FYRRLHTVDF DAGYARFIDD RDDQPHEIHF QALVGSDGAG SALRAAMQRK 190 200 210 220 230 240 APVGEHIAFL DHSYKELEIP PRADGGFRIE RNALHIWPRG RYMCIALPND GGTFTVTLFL 250 260 270 280 290 300 PNEGMPSFAT TRSGDEALAL FARDFPDALP LIPQLKEHWE EHPPGLLGTL TRERWHLDGR 310 320 330 340 350 360 AVLLGDAAHA MVPFHGQGMN CAFEDCVALA EQLDAHSDLS EAFAAFEAAR RDDAAAIQQM 370 380 390 400 410 420 ALENYLEMRD RVGDAQFLLQ RALEQQLQAR WPTRFVPHYT MVTFLRTRYA IALARSEIQR 430 440 450 EILLEATHGH TDLSRIDWVA LETVVHARLE PLEGAH

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000050 Genomic DNA. Translation: AAY49731.1.
RefSeq	YP_243751.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4UT92.
Genome annotation databases
GeneID	3381216.
GenomeReviews	Gene locus XC_2682 in contig CP000050_GR.
KEGG	xcb:XC_2682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UT92.
OMA	LHAIMPS.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_2682-MON.
Family and domain databases
InterPro	IPR002938. mOase_FAD_bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_XANC8

Accession

Primary (citable) accession number: Q4UT92

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 5, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)