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Q4USP7

- LPXB_XANC8

UniProt

Q4USP7 - LPXB_XANC8

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Xanthomonas campestris pv. campestris (strain 8004)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciXCAM314565:GCQG-2892-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:XC_2878
    OrganismiXanthomonas campestris pv. campestris (strain 8004)
    Taxonomic identifieri314565 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
    ProteomesiUP000000420: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Lipid-A-disaccharide synthasePRO_0000255232Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi314565.XC_2878.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4USP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4USP7-1 [UniParc]FASTAAdd to Basket

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    MTGIGNREPE HGAGAHVGAA VSVPDAASIP HSPLPIPGAR MRAPRIALIA    50
    GEASGDILGA GLIDALRRRY PDAEFVGIGG DAMRSAGCQT WFDASELAVM 100
    GLTEVLRHLP RLLKLRSAFR ERVLAWKPDV FIGIDAPDFN LPVERWLKQR 150
    GVRTVHYVSP SVWAWREKRA EKIGVSADLV LCLFPMEPPI YAKHGVDARF 200
    VGHPMADAIA YQADREAARA KLGLSTSSTV LAVLPGSRHG EISRLGDTFF 250
    QAAWLVSEHL PNLHVLVPAA NPGCKQLLAE QLSRSSLPVM RSHLLDGQAR 300
    TAMLAADVVL LASGTATLEA MLVKRPMVVG YKVAPLTYRI VKTLGLLKVN 350
    RYALPNILAN EDLAPELMQD DCTPERLCEA LLDWFKHPEK VAGLQSRYLA 400
    LHAQLRQDAS ARAAEAVAEL LTQRELGIGN RESGGAGS 438
    Length:438
    Mass (Da):47,373
    Last modified:October 31, 2006 - v2
    Checksum:i57F54210F9AF7125
    GO

    Sequence cautioni

    The sequence AAY49926.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000050 Genomic DNA. Translation: AAY49926.1. Different initiation.
    RefSeqiYP_243946.1. NC_007086.1.

    Genome annotation databases

    EnsemblBacteriaiAAY49926; AAY49926; XC_2878.
    GeneIDi3381411.
    KEGGixcb:XC_2878.
    PATRICi24067337. VBIXanCam24967_3047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000050 Genomic DNA. Translation: AAY49926.1 . Different initiation.
    RefSeqi YP_243946.1. NC_007086.1.

    3D structure databases

    ProteinModelPortali Q4USP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 314565.XC_2878.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY49926 ; AAY49926 ; XC_2878 .
    GeneIDi 3381411.
    KEGGi xcb:XC_2878.
    PATRICi 24067337. VBIXanCam24967_3047.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci XCAM314565:GCQG-2892-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris."
      Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L.
      , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.
      Genome Res. 15:757-767(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 8004.

    Entry informationi

    Entry nameiLPXB_XANC8
    AccessioniPrimary (citable) accession number: Q4USP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3