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Q4USP7

- LPXB_XANC8

UniProt

Q4USP7 - LPXB_XANC8

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, XC_2878
Organism
Xanthomonas campestris pv. campestris (strain 8004)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciXCAM314565:GCQG-2892-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:XC_2878
OrganismiXanthomonas campestris pv. campestris (strain 8004)
Taxonomic identifieri314565 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000000420: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi314565.XC_2878.

Structurei

3D structure databases

ProteinModelPortaliQ4USP7.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4USP7-1 [UniParc]FASTAAdd to Basket

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MTGIGNREPE HGAGAHVGAA VSVPDAASIP HSPLPIPGAR MRAPRIALIA    50
GEASGDILGA GLIDALRRRY PDAEFVGIGG DAMRSAGCQT WFDASELAVM 100
GLTEVLRHLP RLLKLRSAFR ERVLAWKPDV FIGIDAPDFN LPVERWLKQR 150
GVRTVHYVSP SVWAWREKRA EKIGVSADLV LCLFPMEPPI YAKHGVDARF 200
VGHPMADAIA YQADREAARA KLGLSTSSTV LAVLPGSRHG EISRLGDTFF 250
QAAWLVSEHL PNLHVLVPAA NPGCKQLLAE QLSRSSLPVM RSHLLDGQAR 300
TAMLAADVVL LASGTATLEA MLVKRPMVVG YKVAPLTYRI VKTLGLLKVN 350
RYALPNILAN EDLAPELMQD DCTPERLCEA LLDWFKHPEK VAGLQSRYLA 400
LHAQLRQDAS ARAAEAVAEL LTQRELGIGN RESGGAGS 438
Length:438
Mass (Da):47,373
Last modified:October 31, 2006 - v2
Checksum:i57F54210F9AF7125
GO

Sequence cautioni

The sequence AAY49926.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000050 Genomic DNA. Translation: AAY49926.1. Different initiation.
RefSeqiYP_243946.1. NC_007086.1.

Genome annotation databases

EnsemblBacteriaiAAY49926; AAY49926; XC_2878.
GeneIDi3381411.
KEGGixcb:XC_2878.
PATRICi24067337. VBIXanCam24967_3047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000050 Genomic DNA. Translation: AAY49926.1 . Different initiation.
RefSeqi YP_243946.1. NC_007086.1.

3D structure databases

ProteinModelPortali Q4USP7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 314565.XC_2878.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY49926 ; AAY49926 ; XC_2878 .
GeneIDi 3381411.
KEGGi xcb:XC_2878.
PATRICi 24067337. VBIXanCam24967_3047.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci XCAM314565:GCQG-2892-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris."
    Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L.
    , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.
    Genome Res. 15:757-767(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 8004.

Entry informationi

Entry nameiLPXB_XANC8
AccessioniPrimary (citable) accession number: Q4USP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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