Q4UP35 (ACSA_XANC8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	XC_4149

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000085007
Sites
	Active site	516	1	By similarity
Amino acid modifications
	Modified residue	608	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UP35 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: B29E360F8DDC9F54	FASTA	647	71,410
	10 20 30 40 50 60 MADVYPVDPA FAADARITRE QYATLYRESI EHPEQFWGKA AQRLDWFKQP TQIKDVSFAL 70 80 90 100 110 120 DDFHVRWFGD GELNASVNCL DRQLATRGDK TALLFEPDSP DSPSYPVTYR ELYERVCKLG 130 140 150 160 170 180 NALRNLGVKK GDRVTIYLPM IVDAAVAMLA CARIGAVHSV VFGGFAANSI ADRVIDCQSK 190 200 210 220 230 240 LIITADEGLR GGKKIPLKAN VDAALKIPGT NTVETVLVVR HTGGAVDMQA PRDRWFHDVV 250 260 270 280 290 300 DGQPAECEPE RMNAEDPLFI LYTSGSTGKP KGVLHTTAGY LLFASYTHEV VFDLREDDIY 310 320 330 340 350 360 WCTADVGWVT GHSYIVYGPL ANGATAVMFE GVPNYPNVSR FWEVIDKHQV TIFYTAPTAI 370 380 390 400 410 420 RALMREGEAP VKKTSRSSLR LLGSVGEPIN PEAWRWYYEV VGDSRCPIVD TWWQTETGGI 430 440 450 460 470 480 LISPLAGAVD LKPGSATLPF FGVQPALVDA EGKILEGATE GNLVLLDSWP GQMRTVYGDH 490 500 510 520 530 540 QRFIDTYFRT YPGSYFTGDG CRRDADGYYW ITGRVDDVIN VSGHRIGTAE VESALVSHPK 550 560 570 580 590 600 VAEAAVVGFP HDVKGQGIYA YVTLIAGETP SEELHKELVS WVRKEIGPIA SPDHLQWAPG 610 620 630 640 LPKTRSGKIM RRILRKIAEN APDQLGDTST LADPSVVDSL VNERLTR

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8004.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000050 Genomic DNA. Translation: AAY51188.1.
RefSeq	YP_245208.1. NC_007086.1.
3D structure databases
ProteinModelPortal	Q4UP35.
SMR	Q4UP35. Positions 9-644.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4UP35.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3379768.
GenomeReviews	Gene locus XC_4149 in contig CP000050_GR.
KEGG	xcb:XC_4149.
PATRIC	24070097. VBIXanCam24967_4400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	HQRMVDT.
PhylomeDB	Q4UP35.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_4149-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_XANC8

Accession

Primary (citable) accession number: Q4UP35

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program