Reviewed, UniProtKB/Swiss-Prot Q4UNZ4 (XYLA2_XANC8)

Names and origin

Protein names

Recommended name:
    Xylose isomerase 2
    EC=5.3.1.5

Gene names

Name:	xylA2
Ordered Locus Names:	XC_4191

Organism

Xanthomonas campestris pv. campestris (strain 8004) [Complete proteome] [HAMAP]

Taxonomic identifier

314565 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Xylose isomerase 2 HAMAP MF_00455		PRO_0000236976
Sites
	Active site	109	1	By similarity
	Active site	112	1	By similarity
	Metal binding	240	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 1 By similarity
	Metal binding	276	1	Magnesium 2 By similarity
	Metal binding	279	1	Magnesium 2 By similarity
	Metal binding	304	1	Magnesium 1 By similarity
	Metal binding	315	1	Magnesium 2 By similarity
	Metal binding	317	1	Magnesium 2 By similarity
	Metal binding	347	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UNZ4-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 515F13FDF24B6C67	FASTA	446	48,792
	10 20 30 40 50 60 MSNTVFIGAK EYFPGIGKIG FEGRDSDNPL AFKVYDANKQ VAGKTMAEHL RFAVAYWHSF 70 80 90 100 110 120 CGNGADPFGP GTRAYPWDVG NTALARAEAK SDAAFEFFTK LGVPYYCFHD IDLAPDADDI 130 140 150 160 170 180 GEYENNLKHM VGIAKQRQAD TGVKLLWGTA NLFSHPRYMN GASTNPDFNV VARAAVQVKA 190 200 210 220 230 240 AIDATVELGG ENYVFWGGRE GYACLHNTQM KREQDNMARF LTLARDYGRA IGFKGNFLIE 250 260 270 280 290 300 PKPMEPMKHQ YDFDSATVIG FLRQHGLDQD FKLNIEANHA TLSGHSFEHD LQVASDAGLL 310 320 330 340 350 360 GSIDANRGNP QNGWDTDQFP TDLYDTVGAM LVVLRQGGLA PGGLNFDAKV RRESSDPQDL 370 380 390 400 410 420 FLAHIGGMDA FARGLEVADA LLTSSPLETW RAQRYASFDS GAGADFANGT STLADLATYA 430 440 AGKGEPTQLS GRQEAYENLI NQYLTR

References

[1]

"Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris." Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q., Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S., Gu W.-Y., Lu G., Rong L. , Tian Y., Yao Z., Fu G., Chen B., Fang R., Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C. Genome Res. 15:757-767(2005) [PubMed: 15899963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000050 Genomic DNA. Translation: AAY51229.1.
RefSeq	YP_245249.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3379809.
GenomeReviews	Gene locus XC_4191 in contig CP000050_GR.
KEGG	xcb:XC_4191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UNZ4.
OMA	Q4UNZ4. FDATASE.
Enzyme and pathway databases
BioCyc	XCAM314565:XC_4191-MON.
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase-typ_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA2_XANC8

Accession

Primary (citable) accession number: Q4UNZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)