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Protein

Putative pyruvate, phosphate dikinase regulatory protein

Gene

RF_0001

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.UniRule annotation

Catalytic activityi

ADP + [pyruvate, phosphate dikinase] = AMP + [pyruvate, phosphate dikinase] phosphate.UniRule annotation
[Pyruvate, phosphate dikinase] phosphate + phosphate = [pyruvate, phosphate dikinase] + diphosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1568ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyruvate, phosphate dikinase regulatory proteinUniRule annotation (EC:2.7.11.32UniRule annotation, EC:2.7.4.27UniRule annotation)
Short name:
PPDK regulatory proteinUniRule annotation
Gene namesi
Ordered Locus Names:RF_0001
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Putative pyruvate, phosphate dikinase regulatory proteinPRO_0000196702Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0001.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1806.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.
OrthoDBiEOG6KHG2N.

Family and domain databases

HAMAPiMF_00921. PDRP.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UNK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLIIHLVS DSSVQTAKYA ANSAFAQFTS IKPKLYHWPM IRNLELLNEV
60 70 80 90 100
LSKIESKHGL VLYTIADQEL RKALTKFCYE LKIPCISVIG KIIKEISVFS
110 120 130 140 150
GIEIEKEQNY NYKFDKTYFD TLNAIDYAIR HDDGQMLNEL SEADIILIGP
160 170 180 190 200
SRTSKTPTSV FLAYNGLKAA NIPYVYNCPF PDFIEKDIDL LVVGLVINPN
210 220 230 240 250
RLIEIREARL NLLQINENKS YTDFNIVQKE CLEVRKICDQ RNWPVIDVST
260 270
RSIEETAALI MRIYYNRKNK YNK
Length:273
Mass (Da):31,559
Last modified:July 5, 2005 - v1
Checksum:iDC8EB17985A8E469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60852.1.
RefSeqiYP_246017.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60852; AAY60852; RF_0001.
GeneIDi3401264.
KEGGirfe:RF_0001.
PATRICi17890308. VBIRicFel64634_0001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60852.1.
RefSeqiYP_246017.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60852; AAY60852; RF_0001.
GeneIDi3401264.
KEGGirfe:RF_0001.
PATRICi17890308. VBIRicFel64634_0001.

Phylogenomic databases

eggNOGiCOG1806.
HOGENOMiHOG000218052.
KOiK09773.
OMAiTSKTPTC.
OrthoDBiEOG6KHG2N.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-1-MONOMER.

Family and domain databases

HAMAPiMF_00921. PDRP.
InterProiIPR005177. Kinase-pyrophosphorylase.
IPR026565. PPDK_reg.
[Graphical view]
PfamiPF03618. Kinase-PPPase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiPDRP_RICFE
AccessioniPrimary (citable) accession number: Q4UNK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2005
Last modified: March 4, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.