Q4UNK3 (THIO_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin
Short name=Trx

Gene names

Name:	trxA
Ordered Locus Names:	RF_0002

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions By similarity.
Sequence similarities	Belongs to the thioredoxin family. Contains 1 thioredoxin domain.
Sequence caution	The sequence AAY60853.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Transport
Domain	Redox-active center
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 105	105	Thioredoxin		PRO_0000272627
Regions
	Domain	1 – 105	105	Thioredoxin
Amino acid modifications
	Disulfide bond	30 ↔ 33		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UNK3 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 4ED3EC8FA0D2D68C	FASTA	105	11,953
	10 20 30 40 50 60 MANNVTDSSF KKEVLESDLP VLVDFWAEWC GPCKMLTPII DEISKELKGK VKVLKMNIDE 70 80 90 100 NPNIPSEYGI RSIPTIMLFK NGEQKDTKIG LQQKNSLLDW INKSI

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY60853.1. Different initiation.
RefSeq	YP_246018.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 1FB6 based on UniProtKB P07591.
ProteinModelPortal	Q4UNK3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3401265.
GenomeReviews	Gene locus RF_0002 in contig CP000053_GR.
KEGG	rfe:RF_0002.
PATRIC	17890312. VBIRicFel64634_0003.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG493509.
OMA	NIDHNAD.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0002-MONOMER.
Family and domain databases
InterPro	IPR005746. Thioredoxin. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03671.
PANTHER	PTHR10438. Trx. 1 hit.
Pfam	PF00085. Thioredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF000077. Thioredoxin. 1 hit.
PRINTS	PR00421. THIOREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR01068. Thioredoxin. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIO_RICFE

Accession

Primary (citable) accession number: Q4UNK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program