Reviewed, UniProtKB/Swiss-Prot Q4UNK0 (FABZ_RICFE)

Names and origin

Protein names

Recommended name:
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
      Short name=(3R)-hydroxymyristoyl ACP dehydrase
    EC=4.2.1.-

Gene names

Name:	fabZ
Ordered Locus Names:	RF_0007

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in saturated fatty acids biosynthesis. HAMAP MF_00406
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thioester dehydratase family. FabZ subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: InterPro lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydro-lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase HAMAP MF_00406		PRO_0000230833
Sites
	Active site	49	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4UNK0-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 013B5330F2ACF973	FASTA	145	16,263
	10 20 30 40 50 60 MIIDITEIMD LIPHRYPFLL VDRVLEIDLN KSIKGIKNVT VNEPQFTGHF PARPVMPGVL 70 80 90 100 110 120 MVEAMAQLAA ILVAKSLGST KNKEVFLMAI ENAKFRRIVQ PGDTMYIHAT IDQQRANVWK 130 140 FSSTVTVEGE MAAESKFTAM IKDKS

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY60858.1.
RefSeq	YP_246023.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400261.
GenomeReviews	Gene locus RF_0007 in contig CP000053_GR.
KEGG	rfe:RF_0007.
NMPDR	fig|315456.3.peg.489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG433282.
OMA	EFIKERR.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0007-MON.
Family and domain databases
HAMAP	MF_00406. [Tree]
InterPro	IPR013114. FabA_FabZ. IPR010084. FabZ. [Graphical view]
Pfam	PF07977. FabA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABZ_RICFE

Accession

Primary (citable) accession number: Q4UNK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 5, 2005
Last modified:	December 15, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)