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Q4UNJ9

- LPXA_RICFE

UniProt

Q4UNJ9 - LPXA_RICFE

Protein

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene

lpxA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-6-MONOMER.
    UniPathwayiUPA00359; UER00477.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferaseUniRule annotation (EC:2.3.1.129UniRule annotation)
    Short name:
    UDP-N-acetylglucosamine acyltransferaseUniRule annotation
    Gene namesi
    Name:lpxAUniRule annotation
    Ordered Locus Names:RF_0006
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferasePRO_0000273128Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UNJ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxA subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1043.
    HOGENOMiHOG000294326.
    KOiK00677.
    OMAiDCQDKKY.
    OrthoDBiEOG6F81P1.

    Family and domain databases

    Gene3Di1.20.1180.10. 1 hit.
    HAMAPiMF_00387. LpxA.
    InterProiIPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PfamiPF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view]
    PIRSFiPIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UNJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNSNIHPTS LIAEKAKLGK NVKIGPYCII GPEVVLHDNV ELKSHVVIEG    50
    ITEIGENTVI YPFASIGQPP QILKYANERS NTIIGSNNTI REYVTVQAGS 100
    QGGGMVTRVG NNNLFMVGVH IGHDCKIGNN VVFANYVSLA GHIEVGDYAI 150
    IGGLSAVHQY ARIGEYSMIG GLSPVGADVI PFGLVSSKRA VLEGLNLIGM 200
    NRKGFDKADS LSALKAIEEI FSGEGNFAER IKQVAEKYKN NSIVMQIIDF 250
    LNQDSSRAFC RFEK 264
    Length:264
    Mass (Da):28,512
    Last modified:July 5, 2005 - v1
    Checksum:i1795106B71E3FA79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60857.1.
    RefSeqiYP_246022.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY60857; AAY60857; RF_0006.
    GeneIDi3400260.
    KEGGirfe:RF_0006.
    PATRICi17890324. VBIRicFel64634_0009.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60857.1 .
    RefSeqi YP_246022.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UNJ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY60857 ; AAY60857 ; RF_0006 .
    GeneIDi 3400260.
    KEGGi rfe:RF_0006.
    PATRICi 17890324. VBIRicFel64634_0009.

    Phylogenomic databases

    eggNOGi COG1043.
    HOGENOMi HOG000294326.
    KOi K00677.
    OMAi DCQDKKY.
    OrthoDBi EOG6F81P1.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00477 .
    BioCyci RFEL315456:GKEK-6-MONOMER.

    Family and domain databases

    Gene3Di 1.20.1180.10. 1 hit.
    HAMAPi MF_00387. LpxA.
    InterProi IPR029098. Acetyltransf_C.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR010137. Lipid_A_LpxA.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    Pfami PF13720. Acetyltransf_11. 1 hit.
    PF00132. Hexapep. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01852. lipid_A_lpxA. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiLPXA_RICFE
    AccessioniPrimary (citable) accession number: Q4UNJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3