Q4UNJ8LPXD_RICFEUDP-3-O-acylglucosamine N-acyltransferase2.3.1.191lpxDRF_0008Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)Rickettsia azadiBacteriaPseudomonadotaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever groupThe genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.Homotrimer.Belongs to the transferase hexapeptide repeat family. LpxD subfamily.AcyltransferaseLipid A biosynthesisLipid biosynthesisLipid metabolismRepeatTransferaseMVSSNFYKNLGPRKLTAIIDFLHDIIEPPKIHEDIAIHDIKILQEASPNDISFLSNPKYSEFLKTTKAAACIVPKNFTGEANPNTVLIHAENSYFAYGKLIDFFYTPIKSYPAKIMKSAIVADSATIGKNCYIGHNVVIEDDVIIGDNSIIEAGSFIGRGVTIGRNARIEQHVSINYTIIGDEVVILAGAKIGQDGFGFSTEKGVHHKIFHIGIVKIGNNVEIGSNITIDRGSLQDTIIEDLCRIDNLVQIGHGVKIGKGSIIVAQAGIAGSSTIGKYCALGGQVGIAGHLNIGDGTQVAAQGGVAQNIEAGKIVGGSPAVPIMDWHRQSIIMKQLVKTSNSKLKK
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