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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei253 – 2531Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-8-MONOMER.
UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Ordered Locus Names:RF_0008
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346UDP-3-O-acylglucosamine N-acyltransferasePRO_0000264430Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0008.

Structurei

3D structure databases

ProteinModelPortaliQ4UNJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294340.
KOiK02536.
OMAiPRVILYQ.
OrthoDBiEOG6JB11D.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UNJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSNFYKNL GPRKLTAIID FLHDIIEPPK IHEDIAIHDI KILQEASPND
60 70 80 90 100
ISFLSNPKYS EFLKTTKAAA CIVPKNFTGE ANPNTVLIHA ENSYFAYGKL
110 120 130 140 150
IDFFYTPIKS YPAKIMKSAI VADSATIGKN CYIGHNVVIE DDVIIGDNSI
160 170 180 190 200
IEAGSFIGRG VTIGRNARIE QHVSINYTII GDEVVILAGA KIGQDGFGFS
210 220 230 240 250
TEKGVHHKIF HIGIVKIGNN VEIGSNITID RGSLQDTIIE DLCRIDNLVQ
260 270 280 290 300
IGHGVKIGKG SIIVAQAGIA GSSTIGKYCA LGGQVGIAGH LNIGDGTQVA
310 320 330 340
AQGGVAQNIE AGKIVGGSPA VPIMDWHRQS IIMKQLVKTS NSKLKK
Length:346
Mass (Da):37,023
Last modified:July 5, 2005 - v1
Checksum:i21AD37F2AAE62C9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60859.1.
RefSeqiWP_011270365.1. NC_007109.1.
YP_246024.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60859; AAY60859; RF_0008.
KEGGirfe:RF_0008.
PATRICi17890330. VBIRicFel64634_0012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60859.1.
RefSeqiWP_011270365.1. NC_007109.1.
YP_246024.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UNJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60859; AAY60859; RF_0008.
KEGGirfe:RF_0008.
PATRICi17890330. VBIRicFel64634_0012.

Phylogenomic databases

eggNOGiCOG1044.
HOGENOMiHOG000294340.
KOiK02536.
OMAiPRVILYQ.
OrthoDBiEOG6JB11D.

Enzyme and pathway databases

UniPathwayiUPA00973.
BioCyciRFEL315456:GKEK-8-MONOMER.

Family and domain databases

HAMAPiMF_00523. LpxD.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 2 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiLPXD_RICFE
AccessioniPrimary (citable) accession number: Q4UNJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2005
Last modified: May 27, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.