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Q4UNJ8 (LPXD_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-3-O-acylglucosamine N-acyltransferase

EC=2.3.1.-
Gene names
Name:lpxD
Ordered Locus Names:RF_0008
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00523

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP-Rule MF_00523

Pathway

Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP-Rule MF_00523

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00523

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   DomainRepeat
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiontransferase activity, transferring acyl groups other than amino-acyl groups

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346UDP-3-O-acylglucosamine N-acyltransferase HAMAP-Rule MF_00523
PRO_0000264430

Sites

Active site2531Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UNJ8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 21AD37F2AAE62C9C

FASTA34637,023
        10         20         30         40         50         60 
MVSSNFYKNL GPRKLTAIID FLHDIIEPPK IHEDIAIHDI KILQEASPND ISFLSNPKYS 

        70         80         90        100        110        120 
EFLKTTKAAA CIVPKNFTGE ANPNTVLIHA ENSYFAYGKL IDFFYTPIKS YPAKIMKSAI 

       130        140        150        160        170        180 
VADSATIGKN CYIGHNVVIE DDVIIGDNSI IEAGSFIGRG VTIGRNARIE QHVSINYTII 

       190        200        210        220        230        240 
GDEVVILAGA KIGQDGFGFS TEKGVHHKIF HIGIVKIGNN VEIGSNITID RGSLQDTIIE 

       250        260        270        280        290        300 
DLCRIDNLVQ IGHGVKIGKG SIIVAQAGIA GSSTIGKYCA LGGQVGIAGH LNIGDGTQVA 

       310        320        330        340 
AQGGVAQNIE AGKIVGGSPA VPIMDWHRQS IIMKQLVKTS NSKLKK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY60859.1.
RefSeqYP_246024.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UNJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY60859; AAY60859; RF_0008.
GeneID3400262.
KEGGrfe:RF_0008.
PATRIC17890330. VBIRicFel64634_0012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1044.
HOGENOMHOG000294340.
KOK02536.
OMASELAYMD.
OrthoDBEOG6JB11D.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-8-MONOMER.
UniPathwayUPA00973.

Family and domain databases

HAMAPMF_00523. LpxD.
InterProIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR011004. Trimer_LpxA-like.
IPR007691. UDP-3-O_GlcNAc_AcTrfase.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamPF00132. Hexapep. 2 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLPXD_RICFE
AccessionPrimary (citable) accession number: Q4UNJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways