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Q4UNJ8

- LPXD_RICFE

UniProt

Q4UNJ8 - LPXD_RICFE

Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei253 – 2531Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups other than amino-acyl groups Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-8-MONOMER.
    UniPathwayiUPA00973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
    Gene namesi
    Name:lpxDUniRule annotation
    Ordered Locus Names:RF_0008
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346UDP-3-O-acylglucosamine N-acyltransferasePRO_0000264430Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0008.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UNJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1044.
    HOGENOMiHOG000294340.
    KOiK02536.
    OMAiSELAYMD.
    OrthoDBiEOG6JB11D.

    Family and domain databases

    HAMAPiMF_00523. LpxD.
    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view]
    PfamiPF00132. Hexapep. 2 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UNJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSSNFYKNL GPRKLTAIID FLHDIIEPPK IHEDIAIHDI KILQEASPND    50
    ISFLSNPKYS EFLKTTKAAA CIVPKNFTGE ANPNTVLIHA ENSYFAYGKL 100
    IDFFYTPIKS YPAKIMKSAI VADSATIGKN CYIGHNVVIE DDVIIGDNSI 150
    IEAGSFIGRG VTIGRNARIE QHVSINYTII GDEVVILAGA KIGQDGFGFS 200
    TEKGVHHKIF HIGIVKIGNN VEIGSNITID RGSLQDTIIE DLCRIDNLVQ 250
    IGHGVKIGKG SIIVAQAGIA GSSTIGKYCA LGGQVGIAGH LNIGDGTQVA 300
    AQGGVAQNIE AGKIVGGSPA VPIMDWHRQS IIMKQLVKTS NSKLKK 346
    Length:346
    Mass (Da):37,023
    Last modified:July 5, 2005 - v1
    Checksum:i21AD37F2AAE62C9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60859.1.
    RefSeqiYP_246024.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY60859; AAY60859; RF_0008.
    GeneIDi3400262.
    KEGGirfe:RF_0008.
    PATRICi17890330. VBIRicFel64634_0012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60859.1 .
    RefSeqi YP_246024.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UNJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY60859 ; AAY60859 ; RF_0008 .
    GeneIDi 3400262.
    KEGGi rfe:RF_0008.
    PATRICi 17890330. VBIRicFel64634_0012.

    Phylogenomic databases

    eggNOGi COG1044.
    HOGENOMi HOG000294340.
    KOi K02536.
    OMAi SELAYMD.
    OrthoDBi EOG6JB11D.

    Enzyme and pathway databases

    UniPathwayi UPA00973 .
    BioCyci RFEL315456:GKEK-8-MONOMER.

    Family and domain databases

    HAMAPi MF_00523. LpxD.
    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR011004. Trimer_LpxA-like.
    IPR007691. UDP-3-O_GlcNAc_AcTrfase.
    IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
    [Graphical view ]
    Pfami PF00132. Hexapep. 2 hits.
    PF04613. LpxD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR01853. lipid_A_lpxD. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiLPXD_RICFE
    AccessioniPrimary (citable) accession number: Q4UNJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3