Reviewed, UniProtKB/Swiss-Prot Q4UNJ8 (LPXD_RICFE)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
    EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	RF_0008

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264430

Sequences

	Sequence		Length	Mass (Da)
	Q4UNJ8-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 21AD37F2AAE62C9C	FASTA	346	37,023
	10 20 30 40 50 60 MVSSNFYKNL GPRKLTAIID FLHDIIEPPK IHEDIAIHDI KILQEASPND ISFLSNPKYS 70 80 90 100 110 120 EFLKTTKAAA CIVPKNFTGE ANPNTVLIHA ENSYFAYGKL IDFFYTPIKS YPAKIMKSAI 130 140 150 160 170 180 VADSATIGKN CYIGHNVVIE DDVIIGDNSI IEAGSFIGRG VTIGRNARIE QHVSINYTII 190 200 210 220 230 240 GDEVVILAGA KIGQDGFGFS TEKGVHHKIF HIGIVKIGNN VEIGSNITID RGSLQDTIIE 250 260 270 280 290 300 DLCRIDNLVQ IGHGVKIGKG SIIVAQAGIA GSSTIGKYCA LGGQVGIAGH LNIGDGTQVA 310 320 330 340 AQGGVAQNIE AGKIVGGSPA VPIMDWHRQS IIMKQLVKTS NSKLKK

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY60859.1.
RefSeq	YP_246024.1.
3D structure databases
HSSP	HSSP built from PDB template 1KRR based on UniProtKB P07464.
ModBase	Search...
Genome annotation databases
GeneID	3400262.
GenomeReviews	Gene locus RF_0008 in contig CP000053_GR.
KEGG	rfe:RF_0008.
NMPDR	fig|315456.3.peg.490.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UNJ8.
OMA	SYPAKIM
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0008-MON.
Family and domain databases
HAMAP	MF_00523. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
Pfam	PF00132. Hexapep. 8 hits. PF04613. LpxD. 1 hit. [Graphical view]
TIGRFAMs	TIGR01853. lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_RICFE

Accession

Primary (citable) accession number: Q4UNJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 5, 2005
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)