Reviewed, UniProtKB/Swiss-Prot Q4UNH3 (DSB_RICFE)

Names and origin

Protein names

Recommended name:
    Putative protein-disulfide oxidoreductase RF_0032
    EC=1.8.-.-

Gene names

Ordered Locus Names:

RF_0032

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May be required for disulfide bond formation in some proteins By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 278	260	Putative protein-disulfide oxidoreductase RF_0032		PRO_0000259990
Regions
	Domain	77 – 266	190	Thioredoxin
Amino acid modifications
	Disulfide bond	119 ↔ 122		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UNH3-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 52818097296CCF18	FASTA	278	31,414
	10 20 30 40 50 60 MRSIFIVPIF LLFLSSCSEE KTQNKNQEEK QIIVQETLQN NNTSQEINQE AVNSENAAES 70 80 90 100 110 120 IVPANDNNQT DEVSTPPSQE QKNPEIKPVK VTFKVDDNDM VLGNKKSNVI VVEYFSPTCP 130 140 150 160 170 180 HCAYYHQTIF PELKKKYIDT NKIAYVVREF IATKQDLDAA ILARCKGDIN SFVQFHNIIL 190 200 210 220 230 240 QQQDKWAYSN KYRELLTDIG QLGGVPPEEY KQCLNSDKIT ETLIANTNFV ANAPKFIGTP 250 260 270 SFFVNGVQTG NYSIDSISTA VDKALEEQKE KAKNEMSL

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY60883.1.
RefSeq	YP_246048.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3401258.
GenomeReviews	Gene locus RF_0032 in contig CP000053_GR.
KEGG	rfe:RF_0032.
NMPDR	fig|315456.3.peg.514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UNH3.
OMA	TLIANTN
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0032-MON.
Family and domain databases
InterPro	IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSB_RICFE

Accession

Primary (citable) accession number: Q4UNH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2006
Last sequence update:	July 5, 2005
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)