Reviewed,
UniProtKB/Swiss-Prot Q4UNF0 (QUEF_RICFE)
Last modified
December 15, 2009.
Version 41.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADPH-dependent 7-cyano-7-deazaguanine reductase EC=1.7.1.13 Alternative name(s): 7-cyano-7-carbaguanine reductase PreQ(0) reductase NADPH-dependent nitrile oxidoreductase | ||||
| Gene names |
| ||||
| Organism | Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 42862 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group |
Protein attributes
| Sequence length | 273 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. |
| Catalytic activity | 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00817 |
| Pathway | tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00817 |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Queuosine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW queuosine biosynthetic processInferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Inferred from electronic annotation. Source: HAMAP queuine synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 273 | 273 | NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00817 | PRO_0000163053 | |||
Sequences
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References
| [1] | "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2. |
Cross-references
Sequence databases | |
|---|---|
| CP000053 Genomic DNA. Translation: AAY60908.1. | |
| RefSeq | YP_246073.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3401240. |
| GenomeReviews | Gene locus RF_0057 in contig CP000053_GR. |
| KEGG | rfe:RF_0057. |
| NMPDR | fig|315456.3.peg.539. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG289139. |
| OMA | INPFRSN. |
Enzyme and pathway databases | |
| BioCyc | RFEL315456:RF_0057-MON. |
| BRENDA | 1.7.1.13. 297363. |
Family and domain databases | |
| HAMAP | MF_00817. [Tree] |
| InterPro | IPR016428. CN_OxRdtase_NADPH-dep_YqcD. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. [Graphical view] |
| Pfam | PF01227. GTP_cyclohydroI. 1 hit. [Graphical view] |
| PIRSF | PIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | QUEF_RICFE | ||||||||
| Accession | Primary (citable) accession number: Q4UNF0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Rickettsia felis (Rickettsia azadi) Rickettsia felis (strain URRWXCal2): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


