Q4UNE6 (SAM_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-adenosylmethionine uptake transporter

Gene names

Name:	sam
Ordered Locus Names:	RF_0061

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transports S-adenosylmethionine By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. [View classification] Contains 2 DUF6 domains.

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	S-adenosylmethionine uptake transporter		PRO_0000280996
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	74 – 91	18	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Transmembrane	148 – 168	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	207 – 227	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
	Domain	21 – 141	121	DUF6 1
	Domain	160 – 280	121	DUF6 2

Sequences

	Sequence		Length	Mass (Da)
	Q4UNE6 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 54F089B6CCD64760	FASTA	294	33,016
	10 20 30 40 50 60 MNDALKTYLT GIGWFLLSLV SSSANDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVFYH 70 80 90 100 110 120 GKNTLKTSRP FVHILRGLLL FFGMTSWTYG LTIAPVTTAT VVSFSIPLFT LILAVFFLNE 130 140 150 160 170 180 NIIWQRWVVT VVGFIGLVVT LKPHTEDFNP EILYFVLAAI SFAMLDIINK KFVIKESMIS 190 200 210 220 230 240 MLFYSAIVTA VVSLPVASQY WLTPSGFELA LLFVLGSSGS LILFFLLKAF SMVDATATAP 250 260 270 280 290 YRYLELVISA IAAYFIFSEF PDKSTLHGAV IIIPATLFII YSEKKAMSRK HESQ

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY60912.1.
RefSeq	YP_246077.1. NC_007109.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3401244.
GenomeReviews	Gene locus RF_0061 in contig CP000053_GR.
KEGG	rfe:RF_0061.
NMPDR	fig|315456.3.peg.543.
PATRIC	17890454. VBIRicFel64634_0072.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG559298.
OMA	QRWVVTV.
ProtClustDB	CLSK870734.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0061-MONOMER.
Family and domain databases
InterPro	IPR000620. DMT. [Graphical view]
KO	K15270.
Pfam	PF00892. EamA. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAM_RICFE

Accession

Primary (citable) accession number: Q4UNE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program