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Protein

Aspartate aminotransferase

Gene

aatA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Aspartate; via amide nitrogenBy similarity
Binding sitei125 – 1251AspartateBy similarity
Binding sitei175 – 1751AspartateBy similarity
Binding sitei375 – 3751AspartateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-77-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aatA
Ordered Locus Names:RF_0074
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Aspartate aminotransferasePRO_0000273125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi315456.RF_0074.

Structurei

3D structure databases

ProteinModelPortaliQ4UND3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYAYPSVK.
OrthoDBiEOG6RRKNS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UND3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIISTRLNS IKPSPTLAVV KKTLELKKAG VDIIALGAGE PDFDTPDNIK
60 70 80 90 100
EAAIKAIKDG FTKYTNVEGM PLLKQAIKDK FKRENNIDYE LDEIIVSTGG
110 120 130 140 150
KQVIYNLFMA SLDKGDKVII PAPYWVSYPD MVALSTGTPV FVNCGIENNF
160 170 180 190 200
KLSAEALERS ITDKTKWLII NSPSNPTGAS YNFEELENIA KVLRKYPHVN
210 220 230 240 250
VMSDDIYEHI TFDDFKFYTL AQIAPDLKER IFTVNGVSKA YSMTGWRIGY
260 270 280 290 300
GVGSKALIKA MTIIQSQSTS NPCSISQMAA IESLNGPQDY IKPNALNFQK
310 320 330 340 350
KRDLALSILK RVKYFECYKP EGAFYLFVKC DKIFGHKTKS GKIIANSNDF
360 370 380 390 400
AEYLLEEAKV AVVPGIAFGL EGYFRISYAT SMEELEEACI RIERACGSIS

IKSSLRGDA
Length:409
Mass (Da):45,448
Last modified:July 5, 2005 - v1
Checksum:i2A7CD6AC91F68343
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60925.1.
RefSeqiWP_011270429.1. NC_007109.1.
YP_246090.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60925; AAY60925; RF_0074.
KEGGirfe:RF_0074.
PATRICi17890482. VBIRicFel64634_0085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60925.1.
RefSeqiWP_011270429.1. NC_007109.1.
YP_246090.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UND3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0074.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60925; AAY60925; RF_0074.
KEGGirfe:RF_0074.
PATRICi17890482. VBIRicFel64634_0085.

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223062.
KOiK00812.
OMAiYAYPSVK.
OrthoDBiEOG6RRKNS.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-77-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiAAT_RICFE
AccessioniPrimary (citable) accession number: Q4UND3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.