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Q4UND3

- AAT_RICFE

UniProt

Q4UND3 - AAT_RICFE

Protein

Aspartate aminotransferase

Gene

aatA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391Aspartate; via amide nitrogenBy similarity
    Binding sitei125 – 1251AspartateBy similarity
    Binding sitei175 – 1751AspartateBy similarity
    Binding sitei375 – 3751AspartateBy similarity

    GO - Molecular functioni

    1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-77-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate aminotransferase (EC:2.6.1.1)
    Short name:
    AspAT
    Alternative name(s):
    Transaminase A
    Gene namesi
    Name:aatA
    Ordered Locus Names:RF_0074
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Aspartate aminotransferasePRO_0000273125Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_0074.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UND3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223062.
    KOiK00812.
    OMAiRCILING.
    OrthoDBiEOG6RRKNS.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UND3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIISTRLNS IKPSPTLAVV KKTLELKKAG VDIIALGAGE PDFDTPDNIK    50
    EAAIKAIKDG FTKYTNVEGM PLLKQAIKDK FKRENNIDYE LDEIIVSTGG 100
    KQVIYNLFMA SLDKGDKVII PAPYWVSYPD MVALSTGTPV FVNCGIENNF 150
    KLSAEALERS ITDKTKWLII NSPSNPTGAS YNFEELENIA KVLRKYPHVN 200
    VMSDDIYEHI TFDDFKFYTL AQIAPDLKER IFTVNGVSKA YSMTGWRIGY 250
    GVGSKALIKA MTIIQSQSTS NPCSISQMAA IESLNGPQDY IKPNALNFQK 300
    KRDLALSILK RVKYFECYKP EGAFYLFVKC DKIFGHKTKS GKIIANSNDF 350
    AEYLLEEAKV AVVPGIAFGL EGYFRISYAT SMEELEEACI RIERACGSIS 400
    IKSSLRGDA 409
    Length:409
    Mass (Da):45,448
    Last modified:July 5, 2005 - v1
    Checksum:i2A7CD6AC91F68343
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60925.1.
    RefSeqiYP_246090.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY60925; AAY60925; RF_0074.
    GeneIDi3400304.
    KEGGirfe:RF_0074.
    PATRICi17890482. VBIRicFel64634_0085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60925.1 .
    RefSeqi YP_246090.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UND3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY60925 ; AAY60925 ; RF_0074 .
    GeneIDi 3400304.
    KEGGi rfe:RF_0074.
    PATRICi 17890482. VBIRicFel64634_0085.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223062.
    KOi K00812.
    OMAi RCILING.
    OrthoDBi EOG6RRKNS.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-77-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiAAT_RICFE
    AccessioniPrimary (citable) accession number: Q4UND3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3