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Q4UND3

- AAT_RICFE

UniProt

Q4UND3 - AAT_RICFE

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Protein

Aspartate aminotransferase

Gene

aatA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Pyridoxal phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Aspartate; via amide nitrogenBy similarity
Binding sitei125 – 1251AspartateBy similarity
Binding sitei175 – 1751AspartateBy similarity
Binding sitei375 – 3751AspartateBy similarity

GO - Molecular functioni

  1. L-aspartate:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  2. L-phenylalanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-77-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferase (EC:2.6.1.1)
Short name:
AspAT
Alternative name(s):
Transaminase A
Gene namesi
Name:aatA
Ordered Locus Names:RF_0074
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Aspartate aminotransferasePRO_0000273125Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi315456.RF_0074.

Structurei

3D structure databases

ProteinModelPortaliQ4UND3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223062.
KOiK00812.
OMAiRCILING.
OrthoDBiEOG6RRKNS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UND3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIISTRLNS IKPSPTLAVV KKTLELKKAG VDIIALGAGE PDFDTPDNIK
60 70 80 90 100
EAAIKAIKDG FTKYTNVEGM PLLKQAIKDK FKRENNIDYE LDEIIVSTGG
110 120 130 140 150
KQVIYNLFMA SLDKGDKVII PAPYWVSYPD MVALSTGTPV FVNCGIENNF
160 170 180 190 200
KLSAEALERS ITDKTKWLII NSPSNPTGAS YNFEELENIA KVLRKYPHVN
210 220 230 240 250
VMSDDIYEHI TFDDFKFYTL AQIAPDLKER IFTVNGVSKA YSMTGWRIGY
260 270 280 290 300
GVGSKALIKA MTIIQSQSTS NPCSISQMAA IESLNGPQDY IKPNALNFQK
310 320 330 340 350
KRDLALSILK RVKYFECYKP EGAFYLFVKC DKIFGHKTKS GKIIANSNDF
360 370 380 390 400
AEYLLEEAKV AVVPGIAFGL EGYFRISYAT SMEELEEACI RIERACGSIS

IKSSLRGDA
Length:409
Mass (Da):45,448
Last modified:July 5, 2005 - v1
Checksum:i2A7CD6AC91F68343
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60925.1.
RefSeqiWP_011270429.1. NC_007109.1.
YP_246090.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60925; AAY60925; RF_0074.
GeneIDi3400304.
KEGGirfe:RF_0074.
PATRICi17890482. VBIRicFel64634_0085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60925.1 .
RefSeqi WP_011270429.1. NC_007109.1.
YP_246090.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UND3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY60925 ; AAY60925 ; RF_0074 .
GeneIDi 3400304.
KEGGi rfe:RF_0074.
PATRICi 17890482. VBIRicFel64634_0085.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223062.
KOi K00812.
OMAi RCILING.
OrthoDBi EOG6RRKNS.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-77-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiAAT_RICFE
AccessioniPrimary (citable) accession number: Q4UND3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3