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Protein

Alanine racemase

Gene

alr

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Active sitei357Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei405Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr
Ordered Locus Names:RF_0079
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002724051 – 462Alanine racemaseAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ4UNC8

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0079

Structurei

3D structure databases

ProteinModelPortaliQ4UNC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 332RPE1 insertAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 132Unknown insertAdd BLAST60

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031445
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
IPR005728 Rickett_RPE
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 2 hits
TIGRFAMsiTIGR01045 RPE1, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4UNC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCTLEINL SAIKNNYLLL QDICKTSLVG AAVKANGYGL GAVQISKALI
60 70 80 90 100
EENCRHFFVA SSEEGVNLRK ALASWHESVF RHCEKNYTVI RRSNPVKNSV
110 120 130 140 150
SQNFFNYFSG LQQCFAPRND GSSIHATTPK ALDNDVNILV LNGVFEHDAL
160 170 180 190 200
ELIEYNLTPV LNNLKQIEIW QKFSNLKNRL LPCYLHFNTG INRLGLTHNE
210 220 230 240 250
IEQLINNRDL LKGLDLQYII SHLAVSEEID NPYNLEQLNR FKTYLQYFPN
260 270 280 290 300
VKASLANSGG IFLGQDYHFD LARPGAALYG LNPVIDLSNN LSYKEEFEGD
310 320 330 340 350
TERRTAAYIN VREDSSTGST YKLPLEGGYS RGLQNPVTLK APIIHLQNLT
360 370 380 390 400
LDSHIGYNMT FTTERDSVIA TLPLGYADGF SRNFSNQGEV FINGRSVPIV
410 420 430 440 450
GRISMDLINI DVTDLPPLDI FLGQEAEIIG NYCTPDKIAS IIGTIGYEVL
460
TSLGSRYKRI YK
Length:462
Mass (Da):51,764
Last modified:July 5, 2005 - v1
Checksum:iB1739EA66F516316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY60930.1
RefSeqiWP_011270434.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY60930; AAY60930; RF_0079
KEGGirfe:RF_0079

Similar proteinsi

Entry informationi

Entry nameiALR_RICFE
AccessioniPrimary (citable) accession number: Q4UNC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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