Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4UNC8 (ALR_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:RF_0079
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Contains 1 RPE1 insert domain.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Alanine racemase HAMAP-Rule MF_01201
PRO_0000272405

Regions

Domain286 – 33247RPE1 insert
Region73 – 13260Unknown insert HAMAP-Rule MF_01201

Sites

Active site341Proton acceptor; specific for D-alanine By similarity
Active site3571Proton acceptor; specific for L-alanine By similarity
Binding site1931Substrate By similarity
Binding site4051Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue341N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UNC8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: B1739EA66F516316

FASTA46251,764
        10         20         30         40         50         60 
MSLCTLEINL SAIKNNYLLL QDICKTSLVG AAVKANGYGL GAVQISKALI EENCRHFFVA 

        70         80         90        100        110        120 
SSEEGVNLRK ALASWHESVF RHCEKNYTVI RRSNPVKNSV SQNFFNYFSG LQQCFAPRND 

       130        140        150        160        170        180 
GSSIHATTPK ALDNDVNILV LNGVFEHDAL ELIEYNLTPV LNNLKQIEIW QKFSNLKNRL 

       190        200        210        220        230        240 
LPCYLHFNTG INRLGLTHNE IEQLINNRDL LKGLDLQYII SHLAVSEEID NPYNLEQLNR 

       250        260        270        280        290        300 
FKTYLQYFPN VKASLANSGG IFLGQDYHFD LARPGAALYG LNPVIDLSNN LSYKEEFEGD 

       310        320        330        340        350        360 
TERRTAAYIN VREDSSTGST YKLPLEGGYS RGLQNPVTLK APIIHLQNLT LDSHIGYNMT 

       370        380        390        400        410        420 
FTTERDSVIA TLPLGYADGF SRNFSNQGEV FINGRSVPIV GRISMDLINI DVTDLPPLDI 

       430        440        450        460 
FLGQEAEIIG NYCTPDKIAS IIGTIGYEVL TSLGSRYKRI YK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY60930.1.
RefSeqYP_246095.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UNC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY60930; AAY60930; RF_0079.
GeneID3400309.
KEGGrfe:RF_0079.
PATRIC17890494. VBIRicFel64634_0091.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031445.
KOK01775.
OMALMGPDYH.
OrthoDBEOG6PP9NJ.
ProtClustDBPRK00053.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-82-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR005728. Rickett_RPE.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01045. RPE1. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_RICFE
AccessionPrimary (citable) accession number: Q4UNC8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways