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Q4UN94

- KDSA_RICFE

UniProt

Q4UN94 - KDSA_RICFE

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Protein

2-dehydro-3-deoxyphosphooctonate aldolase

Gene
kdsA, RF_0113
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-8-phosphooctulonate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-117-MONOMER.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase (EC:2.5.1.55)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name:
KDO 8-P synthase
Short name:
KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene namesi
Name:kdsA
Ordered Locus Names:RF_0113
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742742-dehydro-3-deoxyphosphooctonate aldolaseUniRule annotationPRO_0000277912Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0113.

Structurei

3D structure databases

ProteinModelPortaliQ4UN94.
SMRiQ4UN94. Positions 17-271.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiMESREHA.
OrthoDBiEOG680X4R.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN94-1 [UniParc]FASTAAdd to Basket

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MQKVVKLNNI KIGNDLPFVL IAGPCQIEGK DHALFMAEKL VKLTSKLEIP    50
FIYKSSFDKA NRTSVNGIRG LGIEKGLEIL SKVKSEFDCP IVTDVHSESQ 100
CTETAEIADI LQIPAFLCRQ TDLLQAAAKT GKIVKVKKGQ FLAPWDMKNV 150
QTKLEAFGVK DILFTERGAC FGYNNLVSDM RSLAIIAELN VPVVFDATHS 200
VQQPGGLGGS TGGERKYVEL LAKAATAVGI AGMYMEVHQD PDNAPSDGPC 250
MIKLDNLESI LIKLKKYDKI TKEK 274
Length:274
Mass (Da):29,971
Last modified:July 5, 2005 - v1
Checksum:i103EA00679A60975
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60964.1.
RefSeqiYP_246129.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60964; AAY60964; RF_0113.
GeneIDi3401082.
KEGGirfe:RF_0113.
PATRICi17890576. VBIRicFel64634_0131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60964.1 .
RefSeqi YP_246129.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UN94.
SMRi Q4UN94. Positions 17-271.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY60964 ; AAY60964 ; RF_0113 .
GeneIDi 3401082.
KEGGi rfe:RF_0113.
PATRICi 17890576. VBIRicFel64634_0131.

Phylogenomic databases

eggNOGi COG2877.
HOGENOMi HOG000023021.
KOi K01627.
OMAi MESREHA.
OrthoDBi EOG680X4R.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00357 ; UER00474 .
BioCyci RFEL315456:GKEK-117-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00056. KDO8P_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view ]
PANTHERi PTHR21057:SF2. PTHR21057:SF2. 1 hit.
Pfami PF00793. DAHP_synth_1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01362. KDO8P_synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiKDSA_RICFE
AccessioniPrimary (citable) accession number: Q4UN94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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