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Protein

2-dehydro-3-deoxyphosphooctonate aldolase

Gene

kdsA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-8-phosphooctulonate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-117-MONOMER.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolaseUniRule annotation (EC:2.5.1.55UniRule annotation)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthaseUniRule annotation
KDO-8-phosphate synthaseUniRule annotation
Short name:
KDO 8-P synthaseUniRule annotation
Short name:
KDOPSUniRule annotation
Phospho-2-dehydro-3-deoxyoctonate aldolaseUniRule annotation
Gene namesi
Name:kdsAUniRule annotation
Ordered Locus Names:RF_0113
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2742742-dehydro-3-deoxyphosphooctonate aldolasePRO_0000277912Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0113.

Structurei

3D structure databases

ProteinModelPortaliQ4UN94.
SMRiQ4UN94. Positions 17-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiESRDHAF.
OrthoDBiEOG680X4R.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKVVKLNNI KIGNDLPFVL IAGPCQIEGK DHALFMAEKL VKLTSKLEIP
60 70 80 90 100
FIYKSSFDKA NRTSVNGIRG LGIEKGLEIL SKVKSEFDCP IVTDVHSESQ
110 120 130 140 150
CTETAEIADI LQIPAFLCRQ TDLLQAAAKT GKIVKVKKGQ FLAPWDMKNV
160 170 180 190 200
QTKLEAFGVK DILFTERGAC FGYNNLVSDM RSLAIIAELN VPVVFDATHS
210 220 230 240 250
VQQPGGLGGS TGGERKYVEL LAKAATAVGI AGMYMEVHQD PDNAPSDGPC
260 270
MIKLDNLESI LIKLKKYDKI TKEK
Length:274
Mass (Da):29,971
Last modified:July 5, 2005 - v1
Checksum:i103EA00679A60975
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60964.1.
RefSeqiYP_246129.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60964; AAY60964; RF_0113.
GeneIDi3401082.
KEGGirfe:RF_0113.
PATRICi17890576. VBIRicFel64634_0131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60964.1.
RefSeqiYP_246129.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UN94.
SMRiQ4UN94. Positions 17-271.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60964; AAY60964; RF_0113.
GeneIDi3401082.
KEGGirfe:RF_0113.
PATRICi17890576. VBIRicFel64634_0131.

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiESRDHAF.
OrthoDBiEOG680X4R.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00357; UER00474.
BioCyciRFEL315456:GKEK-117-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiKDSA_RICFE
AccessioniPrimary (citable) accession number: Q4UN94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: February 4, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.