ID   TLCA_RICFE              Reviewed;         498 AA.
AC   Q4UN85;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=ADP,ATP carrier protein 1;
DE   AltName: Full=ADP/ATP translocase 1;
GN   Name=tlcA; Synonyms=tlc1; OrderedLocusNames=RF_0122;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Provides the rickettsial cell with host ATP in exchange for
CC       rickettsial ADP. This is an obligate exchange system. This energy
CC       acquiring activity is an important component of rickettsial parasitism
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the ADP/ATP translocase tlc family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000053; AAY60973.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4UN85; -.
DR   STRING; 315456.RF_0122; -.
DR   KEGG; rfe:RF_0122; -.
DR   eggNOG; COG3202; Bacteria.
DR   HOGENOM; CLU_023964_0_1_5; -.
DR   OrthoDB; 19786at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005471; F:ATP:ADP antiporter activity; IEA:InterPro.
DR   InterPro; IPR004667; ADP_ATP_car_bac_type.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00769; AAA; 1.
DR   PANTHER; PTHR31187; -; 1.
DR   PANTHER; PTHR31187:SF13; ADP,ATP CARRIER PROTEIN 1, CHLOROPLASTIC; 1.
DR   Pfam; PF03219; TLC; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Disulfide bond; Membrane; Nucleotide-binding;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="ADP,ATP carrier protein 1"
FT                   /id="PRO_0000286467"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        55..67
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        89..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        114..147
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        169..184
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        206..218
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        240..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        301..320
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        342..348
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        370..379
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        401..438
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        460..465
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000305"
FT   TOPO_DOM        487..498
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   BINDING         436..442
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..85
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   498 AA;  56708 MW;  C390C2E20C3C58C4 CRC64;
     MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD GFVVTDIGAE
     AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF FLGYFALFAF VLYPYPDLVH
     PDPETIESLS LAYPNFKWFI RIVGKWSFAS FYTMAELWGT MMLSLLFWQF ANQITKTDEA
     KRFYSMFGLL ANLALPVTSV IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM
     NRNVLTDPRL YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV
     WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA MITPLMMLIT
     GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL SKGVKYSLFD ATKNMAYIPL
     DKDLRVKGQA AVEVIGGRFG KSGGAIIQST FFILFPAFGF VEATPYFASI FFVIVILWIY
     AVKGLNKEYQ VLVNKTEK
//