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Q4UN85 (TLCA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Gene names
Name:tlcA
Synonyms:tlc1
Ordered Locus Names:RF_0122
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498ADP,ATP carrier protein 1
PRO_0000286467

Regions

Topological domain1 – 3333Cytoplasmic Probable
Transmembrane34 – 5421Helical; Probable
Topological domain55 – 6713Extracellular Probable
Transmembrane68 – 8821Helical; Probable
Topological domain89 – 924Cytoplasmic Probable
Transmembrane93 – 11321Helical; Probable
Topological domain114 – 14734Extracellular Probable
Transmembrane148 – 16821Helical; Probable
Topological domain169 – 18416Cytoplasmic Probable
Transmembrane185 – 20521Helical; Probable
Topological domain206 – 21813Extracellular Probable
Transmembrane219 – 23921Helical; Probable
Topological domain240 – 27940Cytoplasmic Probable
Transmembrane280 – 30021Helical; Probable
Topological domain301 – 32020Extracellular Probable
Transmembrane321 – 34121Helical; Probable
Topological domain342 – 3487Cytoplasmic Probable
Transmembrane349 – 36921Helical; Probable
Topological domain370 – 37910Extracellular Probable
Transmembrane380 – 40021Helical; Probable
Topological domain401 – 43838Cytoplasmic Probable
Transmembrane439 – 45921Helical; Probable
Topological domain460 – 4656Extracellular Probable
Transmembrane466 – 48621Helical; Probable
Topological domain487 – 49812Cytoplasmic Probable
Nucleotide binding436 – 4427ATP Potential

Amino acid modifications

Disulfide bond37 ↔ 85 Probable

Sequences

Sequence LengthMass (Da)Tools
Q4UN85 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: C390C2E20C3C58C4

FASTA49856,708
        10         20         30         40         50         60 
MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD GFVVTDIGAE 

        70         80         90        100        110        120 
AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF FLGYFALFAF VLYPYPDLVH 

       130        140        150        160        170        180 
PDPETIESLS LAYPNFKWFI RIVGKWSFAS FYTMAELWGT MMLSLLFWQF ANQITKTDEA 

       190        200        210        220        230        240 
KRFYSMFGLL ANLALPVTSV IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM 

       250        260        270        280        290        300 
NRNVLTDPRL YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV 

       310        320        330        340        350        360 
WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA MITPLMMLIT 

       370        380        390        400        410        420 
GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL SKGVKYSLFD ATKNMAYIPL 

       430        440        450        460        470        480 
DKDLRVKGQA AVEVIGGRFG KSGGAIIQST FFILFPAFGF VEATPYFASI FFVIVILWIY 

       490 
AVKGLNKEYQ VLVNKTEK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqYP_246138.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY60973; AAY60973; RF_0122.
GeneID3400833.
KEGGrfe:RF_0122.
PATRIC17890594. VBIRicFel64634_0140.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
KOK03301.
OMANWTFAAF.
OrthoDBEOG6BCSND.
ProtClustDBCLSK870724.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-126-MONOMER.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCA_RICFE
AccessionPrimary (citable) accession number: Q4UN85
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names