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Q4UN85

- TLCA_RICFE

UniProt

Q4UN85 - TLCA_RICFE

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Protein

ADP,ATP carrier protein 1

Gene
tlcA, tlc1, RF_0122
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi436 – 4427ATP Reviewed prediction

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Gene namesi
Name:tlcA
Synonyms:tlc1
Ordered Locus Names:RF_0122
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Cytoplasmic InferredAdd
BLAST
Transmembranei34 – 5421Helical; InferredAdd
BLAST
Topological domaini55 – 6713Extracellular InferredAdd
BLAST
Transmembranei68 – 8821Helical; InferredAdd
BLAST
Topological domaini89 – 924Cytoplasmic Inferred
Transmembranei93 – 11321Helical; InferredAdd
BLAST
Topological domaini114 – 14734Extracellular InferredAdd
BLAST
Transmembranei148 – 16821Helical; InferredAdd
BLAST
Topological domaini169 – 18416Cytoplasmic InferredAdd
BLAST
Transmembranei185 – 20521Helical; InferredAdd
BLAST
Topological domaini206 – 21813Extracellular InferredAdd
BLAST
Transmembranei219 – 23921Helical; InferredAdd
BLAST
Topological domaini240 – 27940Cytoplasmic InferredAdd
BLAST
Transmembranei280 – 30021Helical; InferredAdd
BLAST
Topological domaini301 – 32020Extracellular InferredAdd
BLAST
Transmembranei321 – 34121Helical; InferredAdd
BLAST
Topological domaini342 – 3487Cytoplasmic Inferred
Transmembranei349 – 36921Helical; InferredAdd
BLAST
Topological domaini370 – 37910Extracellular Inferred
Transmembranei380 – 40021Helical; InferredAdd
BLAST
Topological domaini401 – 43838Cytoplasmic InferredAdd
BLAST
Transmembranei439 – 45921Helical; InferredAdd
BLAST
Topological domaini460 – 4656Extracellular Inferred
Transmembranei466 – 48621Helical; InferredAdd
BLAST
Topological domaini487 – 49812Cytoplasmic InferredAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498ADP,ATP carrier protein 1PRO_0000286467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 85 Inferred

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0122.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3202.
HOGENOMiHOG000238123.
KOiK03301.
OMAiIESWSVA.
OrthoDBiEOG6BCSND.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00769. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN85-1 [UniParc]FASTAAdd to Basket

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MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD    50
GFVVTDIGAE AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF 100
FLGYFALFAF VLYPYPDLVH PDPETIESLS LAYPNFKWFI RIVGKWSFAS 150
FYTMAELWGT MMLSLLFWQF ANQITKTDEA KRFYSMFGLL ANLALPVTSV 200
IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM NRNVLTDPRL 250
YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV 300
WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA 350
MITPLMMLIT GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL 400
SKGVKYSLFD ATKNMAYIPL DKDLRVKGQA AVEVIGGRFG KSGGAIIQST 450
FFILFPAFGF VEATPYFASI FFVIVILWIY AVKGLNKEYQ VLVNKTEK 498
Length:498
Mass (Da):56,708
Last modified:July 5, 2005 - v1
Checksum:iC390C2E20C3C58C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqiYP_246138.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
GeneIDi3400833.
KEGGirfe:RF_0122.
PATRICi17890594. VBIRicFel64634_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1 .
RefSeqi YP_246138.1. NC_007109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY60973 ; AAY60973 ; RF_0122 .
GeneIDi 3400833.
KEGGi rfe:RF_0122.
PATRICi 17890594. VBIRicFel64634_0140.

Phylogenomic databases

eggNOGi COG3202.
HOGENOMi HOG000238123.
KOi K03301.
OMAi IESWSVA.
OrthoDBi EOG6BCSND.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-126-MONOMER.

Family and domain databases

InterProi IPR004667. ADP_ATP_car.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF03219. TLC. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00769. AAA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTLCA_RICFE
AccessioniPrimary (citable) accession number: Q4UN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi