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Protein

ADP,ATP carrier protein 1

Gene

tlcA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi436 – 442ATPSequence analysis7

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Gene namesi
Name:tlcA
Synonyms:tlc1
Ordered Locus Names:RF_0122
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicCuratedAdd BLAST33
Transmembranei34 – 54HelicalCuratedAdd BLAST21
Topological domaini55 – 67ExtracellularCuratedAdd BLAST13
Transmembranei68 – 88HelicalCuratedAdd BLAST21
Topological domaini89 – 92CytoplasmicCurated4
Transmembranei93 – 113HelicalCuratedAdd BLAST21
Topological domaini114 – 147ExtracellularCuratedAdd BLAST34
Transmembranei148 – 168HelicalCuratedAdd BLAST21
Topological domaini169 – 184CytoplasmicCuratedAdd BLAST16
Transmembranei185 – 205HelicalCuratedAdd BLAST21
Topological domaini206 – 218ExtracellularCuratedAdd BLAST13
Transmembranei219 – 239HelicalCuratedAdd BLAST21
Topological domaini240 – 279CytoplasmicCuratedAdd BLAST40
Transmembranei280 – 300HelicalCuratedAdd BLAST21
Topological domaini301 – 320ExtracellularCuratedAdd BLAST20
Transmembranei321 – 341HelicalCuratedAdd BLAST21
Topological domaini342 – 348CytoplasmicCurated7
Transmembranei349 – 369HelicalCuratedAdd BLAST21
Topological domaini370 – 379ExtracellularCurated10
Transmembranei380 – 400HelicalCuratedAdd BLAST21
Topological domaini401 – 438CytoplasmicCuratedAdd BLAST38
Transmembranei439 – 459HelicalCuratedAdd BLAST21
Topological domaini460 – 465ExtracellularCurated6
Transmembranei466 – 486HelicalCuratedAdd BLAST21
Topological domaini487 – 498CytoplasmicCuratedAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864671 – 498ADP,ATP carrier protein 1Add BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 85Curated

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0122.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP/ATP translocase tlc family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E7T. Bacteria.
COG3202. LUCA.
HOGENOMiHOG000238123.
KOiK03301.
OMAiRKVIWPI.
OrthoDBiPOG091H0NNH.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR31187. PTHR31187. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00769. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD
60 70 80 90 100
GFVVTDIGAE AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF
110 120 130 140 150
FLGYFALFAF VLYPYPDLVH PDPETIESLS LAYPNFKWFI RIVGKWSFAS
160 170 180 190 200
FYTMAELWGT MMLSLLFWQF ANQITKTDEA KRFYSMFGLL ANLALPVTSV
210 220 230 240 250
IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM NRNVLTDPRL
260 270 280 290 300
YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV
310 320 330 340 350
WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA
360 370 380 390 400
MITPLMMLIT GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL
410 420 430 440 450
SKGVKYSLFD ATKNMAYIPL DKDLRVKGQA AVEVIGGRFG KSGGAIIQST
460 470 480 490
FFILFPAFGF VEATPYFASI FFVIVILWIY AVKGLNKEYQ VLVNKTEK
Length:498
Mass (Da):56,708
Last modified:July 5, 2005 - v1
Checksum:iC390C2E20C3C58C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqiWP_011270476.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
KEGGirfe:RF_0122.
PATRICi17890594. VBIRicFel64634_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqiWP_011270476.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
KEGGirfe:RF_0122.
PATRICi17890594. VBIRicFel64634_0140.

Phylogenomic databases

eggNOGiENOG4105E7T. Bacteria.
COG3202. LUCA.
HOGENOMiHOG000238123.
KOiK03301.
OMAiRKVIWPI.
OrthoDBiPOG091H0NNH.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR31187. PTHR31187. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00769. AAA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTLCA_RICFE
AccessioniPrimary (citable) accession number: Q4UN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.