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Protein

ADP,ATP carrier protein 1

Gene

tlcA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi436 – 4427ATPSequence Analysis

GO - Molecular functioni

  1. ATP:ADP antiporter activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 1
Alternative name(s):
ADP/ATP translocase 1
Gene namesi
Name:tlcA
Synonyms:tlc1
Ordered Locus Names:RF_0122
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicCuratedAdd
BLAST
Transmembranei34 – 5421HelicalCuratedAdd
BLAST
Topological domaini55 – 6713ExtracellularCuratedAdd
BLAST
Transmembranei68 – 8821HelicalCuratedAdd
BLAST
Topological domaini89 – 924CytoplasmicCurated
Transmembranei93 – 11321HelicalCuratedAdd
BLAST
Topological domaini114 – 14734ExtracellularCuratedAdd
BLAST
Transmembranei148 – 16821HelicalCuratedAdd
BLAST
Topological domaini169 – 18416CytoplasmicCuratedAdd
BLAST
Transmembranei185 – 20521HelicalCuratedAdd
BLAST
Topological domaini206 – 21813ExtracellularCuratedAdd
BLAST
Transmembranei219 – 23921HelicalCuratedAdd
BLAST
Topological domaini240 – 27940CytoplasmicCuratedAdd
BLAST
Transmembranei280 – 30021HelicalCuratedAdd
BLAST
Topological domaini301 – 32020ExtracellularCuratedAdd
BLAST
Transmembranei321 – 34121HelicalCuratedAdd
BLAST
Topological domaini342 – 3487CytoplasmicCurated
Transmembranei349 – 36921HelicalCuratedAdd
BLAST
Topological domaini370 – 37910ExtracellularCurated
Transmembranei380 – 40021HelicalCuratedAdd
BLAST
Topological domaini401 – 43838CytoplasmicCuratedAdd
BLAST
Transmembranei439 – 45921HelicalCuratedAdd
BLAST
Topological domaini460 – 4656ExtracellularCurated
Transmembranei466 – 48621HelicalCuratedAdd
BLAST
Topological domaini487 – 49812CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498ADP,ATP carrier protein 1PRO_0000286467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 85Curated

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0122.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP/ATP translocase tlc family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3202.
HOGENOMiHOG000238123.
KOiK03301.
OMAiRKVIWPI.
OrthoDBiEOG6BCSND.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR31187:SF0. PTHR31187:SF0. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00769. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD
60 70 80 90 100
GFVVTDIGAE AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF
110 120 130 140 150
FLGYFALFAF VLYPYPDLVH PDPETIESLS LAYPNFKWFI RIVGKWSFAS
160 170 180 190 200
FYTMAELWGT MMLSLLFWQF ANQITKTDEA KRFYSMFGLL ANLALPVTSV
210 220 230 240 250
IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM NRNVLTDPRL
260 270 280 290 300
YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV
310 320 330 340 350
WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA
360 370 380 390 400
MITPLMMLIT GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL
410 420 430 440 450
SKGVKYSLFD ATKNMAYIPL DKDLRVKGQA AVEVIGGRFG KSGGAIIQST
460 470 480 490
FFILFPAFGF VEATPYFASI FFVIVILWIY AVKGLNKEYQ VLVNKTEK
Length:498
Mass (Da):56,708
Last modified:July 5, 2005 - v1
Checksum:iC390C2E20C3C58C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqiWP_011270476.1. NC_007109.1.
YP_246138.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
GeneIDi3400833.
KEGGirfe:RF_0122.
PATRICi17890594. VBIRicFel64634_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60973.1.
RefSeqiWP_011270476.1. NC_007109.1.
YP_246138.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
GeneIDi3400833.
KEGGirfe:RF_0122.
PATRICi17890594. VBIRicFel64634_0140.

Phylogenomic databases

eggNOGiCOG3202.
HOGENOMiHOG000238123.
KOiK03301.
OMAiRKVIWPI.
OrthoDBiEOG6BCSND.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-126-MONOMER.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR31187:SF0. PTHR31187:SF0. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00769. AAA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTLCA_RICFE
AccessioniPrimary (citable) accession number: Q4UN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.