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Q4UN85

- TLCA_RICFE

UniProt

Q4UN85 - TLCA_RICFE

Protein

ADP,ATP carrier protein 1

Gene

tlcA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi436 – 4427ATPSequence Analysis

    GO - Molecular functioni

    1. ATP:ADP antiporter activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-126-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP,ATP carrier protein 1
    Alternative name(s):
    ADP/ATP translocase 1
    Gene namesi
    Name:tlcA
    Synonyms:tlc1
    Ordered Locus Names:RF_0122
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498ADP,ATP carrier protein 1PRO_0000286467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 85Curated

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0122.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicCuratedAdd
    BLAST
    Topological domaini55 – 6713ExtracellularCuratedAdd
    BLAST
    Topological domaini89 – 924CytoplasmicCurated
    Topological domaini114 – 14734ExtracellularCuratedAdd
    BLAST
    Topological domaini169 – 18416CytoplasmicCuratedAdd
    BLAST
    Topological domaini206 – 21813ExtracellularCuratedAdd
    BLAST
    Topological domaini240 – 27940CytoplasmicCuratedAdd
    BLAST
    Topological domaini301 – 32020ExtracellularCuratedAdd
    BLAST
    Topological domaini342 – 3487CytoplasmicCurated
    Topological domaini370 – 37910ExtracellularCurated
    Topological domaini401 – 43838CytoplasmicCuratedAdd
    BLAST
    Topological domaini460 – 4656ExtracellularCurated
    Topological domaini487 – 49812CytoplasmicCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalCuratedAdd
    BLAST
    Transmembranei68 – 8821HelicalCuratedAdd
    BLAST
    Transmembranei93 – 11321HelicalCuratedAdd
    BLAST
    Transmembranei148 – 16821HelicalCuratedAdd
    BLAST
    Transmembranei185 – 20521HelicalCuratedAdd
    BLAST
    Transmembranei219 – 23921HelicalCuratedAdd
    BLAST
    Transmembranei280 – 30021HelicalCuratedAdd
    BLAST
    Transmembranei321 – 34121HelicalCuratedAdd
    BLAST
    Transmembranei349 – 36921HelicalCuratedAdd
    BLAST
    Transmembranei380 – 40021HelicalCuratedAdd
    BLAST
    Transmembranei439 – 45921HelicalCuratedAdd
    BLAST
    Transmembranei466 – 48621HelicalCuratedAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP/ATP translocase tlc family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3202.
    HOGENOMiHOG000238123.
    KOiK03301.
    OMAiIESWSVA.
    OrthoDBiEOG6BCSND.

    Family and domain databases

    InterProiIPR004667. ADP_ATP_car.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF03219. TLC. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00769. AAA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UN85-1 [UniParc]FASTAAdd to Basket

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    MNTPKSDNYL SELRKVIWPI EKYENKKFLP MAFMMFCILL NYSTLRSIKD    50
    GFVVTDIGAE AISFLKTYIV LPSAVIAMVI YVKLCDILKQ ENVFYVITSF 100
    FLGYFALFAF VLYPYPDLVH PDPETIESLS LAYPNFKWFI RIVGKWSFAS 150
    FYTMAELWGT MMLSLLFWQF ANQITKTDEA KRFYSMFGLL ANLALPVTSV 200
    IIGYFLHEKT QIVAEHLKFV PLFVIMITSS FLVILTYRWM NRNVLTDPRL 250
    YDPALVKEKK AKAKMSLIDS FKMIFTSKYV GYIALLLIAY GISVNLVEGV 300
    WKSKVKELYP TKEAYTIYMG KFQFYQGWVA IAFMLIGSNI LRKVSWLAAA 350
    MITPLMMLIT GAAFFAFIFF DSVIAMHLTG ILASGPLALA VMIGMIQNVL 400
    SKGVKYSLFD ATKNMAYIPL DKDLRVKGQA AVEVIGGRFG KSGGAIIQST 450
    FFILFPAFGF VEATPYFASI FFVIVILWIY AVKGLNKEYQ VLVNKTEK 498
    Length:498
    Mass (Da):56,708
    Last modified:July 5, 2005 - v1
    Checksum:iC390C2E20C3C58C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60973.1.
    RefSeqiYP_246138.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY60973; AAY60973; RF_0122.
    GeneIDi3400833.
    KEGGirfe:RF_0122.
    PATRICi17890594. VBIRicFel64634_0140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY60973.1 .
    RefSeqi YP_246138.1. NC_007109.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY60973 ; AAY60973 ; RF_0122 .
    GeneIDi 3400833.
    KEGGi rfe:RF_0122.
    PATRICi 17890594. VBIRicFel64634_0140.

    Phylogenomic databases

    eggNOGi COG3202.
    HOGENOMi HOG000238123.
    KOi K03301.
    OMAi IESWSVA.
    OrthoDBi EOG6BCSND.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-126-MONOMER.

    Family and domain databases

    InterProi IPR004667. ADP_ATP_car.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF03219. TLC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00769. AAA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiTLCA_RICFE
    AccessioniPrimary (citable) accession number: Q4UN85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3