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Q4UN76 (YIDC_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane protein insertase YidC
Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Gene names
Name:yidC
Ordered Locus Names:RF_0131
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity. HAMAP-Rule MF_01810

Subunit structure

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01810.

Sequence similarities

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein insertion into membrane

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Membrane protein insertase YidC HAMAP-Rule MF_01810
PRO_0000272371

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane334 – 35421Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane431 – 45121Helical; Potential
Transmembrane476 – 49621Helical; Potential
Transmembrane522 – 54221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UN76 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: F19BA53348557CBB

FASTA56064,462
        10         20         30         40         50         60 
MNNNIINLIA AIILSLSIIF GWQYFVVKPE QKKQQQQIAV QKAENLKKQQ LKALVEPATD 

        70         80         90        100        110        120 
IVVQEESGVQ RIKIESESLT GSISLKGLRF DDLILKKYKQ DLSNNSPEVR LFSPANTENA 

       130        140        150        160        170        180 
YFAEIGLVSN LSSVKLPNND TIWNSDSEIL SPEKPVNLFW VNEDGVKFLV TITVDENYLF 

       190        200        210        220        230        240 
TIEQTIVNNS DKELPIQSYG LINRKYTAVE KAVNILHQGP IGCIDENLKE YSYDDIKDKK 

       250        260        270        280        290        300 
SEKFAASKVD WIGITDKYWL SSLIPDKSSN YSSNFNYALK QGTERYQVDF ISPVQIIKPG 

       310        320        330        340        350        360 
ENFSIKSRIF AGAKKVDLLD KYEKQYDIKL FDRAIDFGWF YIITKPVFYA MNFFYGYVGN 

       370        380        390        400        410        420 
FGVSILIVTV IIKLLMFTLA NKSYRSMKKM KNLQPEIDRI KNLYSDDKAR LNQEIMALYK 

       430        440        450        460        470        480 
KEKVNPVAGC LPILVQIPLF FSIYKVLYVT IEMRQVPFYG WIKDLSAPDP TTIFNLFGLL 

       490        500        510        520        530        540 
PFSPPSFLMI GAWPILMAIT MFLQQKMSPE PADPMQAQVM KFMPLIFLFM FSSFPVGLLI 

       550        560 
YWSWNNILSI IQQYYINKFN 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY60982.1.
RefSeqYP_246147.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0131.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY60982; AAY60982; RF_0131.
GeneID3400842.
KEGGrfe:RF_0131.
PATRIC17890614. VBIRicFel64634_0150.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0706.
HOGENOMHOG000101821.
KOK03217.
OMAFVTIEMR.
OrthoDBEOG6X6RF2.
ProtClustDBPRK01318.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-135-MONOMER.

Family and domain databases

HAMAPMF_01810. YidC_type1.
InterProIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERPTHR12428. PTHR12428. 1 hit.
PfamPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYIDC_RICFE
AccessionPrimary (citable) accession number: Q4UN76
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names