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Protein

Succinate dehydrogenase iron-sulfur subunit

Gene

sdhB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi85 – 851Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi171 – 1711Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi174 – 1741Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi177 – 1771Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi181 – 1811Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei186 – 1861Ubiquinone; shared with SdhD subunitBy similarity
Metal bindingi228 – 2281Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi234 – 2341Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi238 – 2381Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-140-MONOMER.
UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:sdhB
Ordered Locus Names:RF_0136
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Succinate dehydrogenase iron-sulfur subunitPRO_0000280983Add
BLAST

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Protein-protein interaction databases

STRINGi315456.RF_0136.

Structurei

3D structure databases

ProteinModelPortaliQ4UN71.
SMRiQ4UN71. Positions 28-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 119922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini161 – 191314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
KOiK00240.
OMAiIQVTQAI.
OrthoDBiEOG6CK7MG.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UN71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELRLPPNS VVKKGKEHKE QEEMLKPRKV KIYRYDPDLD ENPTIDSFEI
60 70 80 90 100
DLSKTGPMVL DALIKIKNEI DSTLTFRRSC REGICGSCSM NIDGTNTLAC
110 120 130 140 150
IKPIEEISGD IKIYPLPHMK VVKDLVPDMS HFYAQYESIE PWLKTDSPTP
160 170 180 190 200
SNSERLQSIK GREKLDGLYE CILCACCSTS CPSYWWNGDK YLGPAILLQA
210 220 230 240 250
YRWIADSRDD HTGERLEDLE DPSKLYRCHT IMNCTKTCPK GLNPAKAIGK
260
IKSLIAERHG V
Length:261
Mass (Da):29,613
Last modified:July 5, 2005 - v1
Checksum:iA3BD2326E50BF9B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60987.1.
RefSeqiWP_011270490.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY60987; AAY60987; RF_0136.
KEGGirfe:RF_0136.
PATRICi17890624. VBIRicFel64634_0155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY60987.1.
RefSeqiWP_011270490.1. NC_007109.1.

3D structure databases

ProteinModelPortaliQ4UN71.
SMRiQ4UN71. Positions 28-256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0136.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY60987; AAY60987; RF_0136.
KEGGirfe:RF_0136.
PATRICi17890624. VBIRicFel64634_0155.

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
KOiK00240.
OMAiIQVTQAI.
OrthoDBiEOG6CK7MG.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.
BioCyciRFEL315456:GKEK-140-MONOMER.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiSDHB_RICFE
AccessioniPrimary (citable) accession number: Q4UN71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: July 22, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.