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Q4UN71 (SDHB_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
Ordered Locus Names:RF_0136
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Succinate dehydrogenase iron-sulfur subunit
PRO_0000280983

Regions

Domain28 – 119922Fe-2S ferredoxin-type
Domain161 – 191314Fe-4S ferredoxin-type

Sites

Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding851Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1711Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1741Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1771Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1811Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2281Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2341Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2381Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1861Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4UN71 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: A3BD2326E50BF9B5

FASTA26129,613
        10         20         30         40         50         60 
MAELRLPPNS VVKKGKEHKE QEEMLKPRKV KIYRYDPDLD ENPTIDSFEI DLSKTGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DSTLTFRRSC REGICGSCSM NIDGTNTLAC IKPIEEISGD IKIYPLPHMK 

       130        140        150        160        170        180 
VVKDLVPDMS HFYAQYESIE PWLKTDSPTP SNSERLQSIK GREKLDGLYE CILCACCSTS 

       190        200        210        220        230        240 
CPSYWWNGDK YLGPAILLQA YRWIADSRDD HTGERLEDLE DPSKLYRCHT IMNCTKTCPK 

       250        260 
GLNPAKAIGK IKSLIAERHG V 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY60987.1.
RefSeqYP_246152.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UN71.
SMRQ4UN71. Positions 28-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0136.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY60987; AAY60987; RF_0136.
GeneID3400637.
KEGGrfe:RF_0136.
PATRIC17890624. VBIRicFel64634_0155.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00240.
OMAQYEKIRP.
OrthoDBEOG6CK7MG.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-140-MONOMER.
UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_RICFE
AccessionPrimary (citable) accession number: Q4UN71
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways