ID   Q4UN54_RICFE            Unreviewed;       241 AA.
AC   Q4UN54;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 113.
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] reductase FabG {ECO:0000256|ARBA:ARBA00017650};
DE   AltName: Full=3-ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00033040};
DE   AltName: Full=Beta-Ketoacyl-acyl carrier protein reductase {ECO:0000256|ARBA:ARBA00029743, ECO:0000256|ARBA:ARBA00032683};
DE   AltName: Full=Beta-ketoacyl-ACP reductase {ECO:0000256|ARBA:ARBA00029899};
GN   Name=phbB {ECO:0000313|EMBL:AAY61004.1};
GN   OrderedLocusNames=RF_0153 {ECO:0000313|EMBL:AAY61004.1};
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456 {ECO:0000313|EMBL:AAY61004.1, ECO:0000313|Proteomes:UP000008548};
RN   [1] {ECO:0000313|EMBL:AAY61004.1, ECO:0000313|Proteomes:UP000008548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2 {ECO:0000313|Proteomes:UP000008548};
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.E.,
RA   Parinello H., Claverie J.M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
RN   [2] {ECO:0007829|PDB:4KMS}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
RX   PubMed=33620038; DOI=10.1107/s2053230x21001497;
RA   Rodarte J.V., Abendroth J., Edwards T.E., Lorimer D.D., Staker B.L.,
RA   Zhang S., Myler P.J., McLaughlin K.J.;
RT   "Crystal structure of acetoacetyl-CoA reductase from Rickettsia felis.";
RL   Acta Crystallogr. F Struct. Biol. Commun. 77:54-60(2021).
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP
CC       substrates to beta-hydroxyacyl-ACP products, the first reductive step
CC       in the elongation cycle of fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00002607}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000053; AAY61004.1; -; Genomic_DNA.
DR   PDB; 4KMS; X-ray; 2.00 A; A/B=1-241.
DR   PDBsum; 4KMS; -.
DR   AlphaFoldDB; Q4UN54; -.
DR   SMR; Q4UN54; -.
DR   STRING; 315456.RF_0153; -.
DR   KEGG; rfe:RF_0153; -.
DR   eggNOG; COG1028; Bacteria.
DR   HOGENOM; CLU_010194_1_3_5; -.
DR   OrthoDB; 9804774at2; -.
DR   BRENDA; 1.1.1.36; 15352.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0018454; F:acetoacetyl-CoA reductase activity; IEA:InterPro.
DR   GO; GO:0042619; P:poly-hydroxybutyrate biosynthetic process; IEA:InterPro.
DR   CDD; cd05333; BKR_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR011283; Acetoacetyl-CoA_reductase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   NCBIfam; TIGR01829; AcAcCoA_reduct; 1.
DR   PANTHER; PTHR42879; 3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE; 1.
DR   PANTHER; PTHR42879:SF2; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG; 1.
DR   Pfam; PF13561; adh_short_C2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4KMS};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Oxidoreductase {ECO:0000313|EMBL:AAY61004.1}.
SQ   SEQUENCE   241 AA;  26252 MW;  FB09A2EDA99C0651 CRC64;
     MSEIAIVTGG TRGIGKATAL ELKNKGLTVV ANFFSNYDAA KEMEEKYGIK TKCWNVADFE
     ECRQAVKEIE EEFKKPVSIL VNNAGITKDK MLHRMSHQDW NDVINVNLNS CFNMSSSVME
     QMRNQDYGRI VNISSINAQA GQVGQTNYSA AKAGIIGFTK ALARETASKN ITVNCIAPGY
     IATEMVGAVP EDVLAKIINS IPKKRLGQPE EIARAVAFLV DENAGFITGE TISINGGHNM
     I
//