Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Acetoacetyl-CoA reductase

Gene

phbB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB-EC
  2. acetoacetyl-CoA reductase activity Source: InterPro

GO - Biological processi

  1. poly-hydroxybutyrate biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-157-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Acetoacetyl-CoA reductaseImported (EC:1.1.1.100Imported)
Gene namesi
Name:phbBImported
Ordered Locus Names:RF_0153Imported
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)Imported
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0153.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KMSX-ray2.00A/B1-241[»]
ProteinModelPortaliQ4UN54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

KOiK00023.
OMAiNIANFEE.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UN54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEIAIVTGG TRGIGKATAL ELKNKGLTVV ANFFSNYDAA KEMEEKYGIK
60 70 80 90 100
TKCWNVADFE ECRQAVKEIE EEFKKPVSIL VNNAGITKDK MLHRMSHQDW
110 120 130 140 150
NDVINVNLNS CFNMSSSVME QMRNQDYGRI VNISSINAQA GQVGQTNYSA
160 170 180 190 200
AKAGIIGFTK ALARETASKN ITVNCIAPGY IATEMVGAVP EDVLAKIINS
210 220 230 240
IPKKRLGQPE EIARAVAFLV DENAGFITGE TISINGGHNM I
Length:241
Mass (Da):26,252
Last modified:July 5, 2005 - v1
Checksum:iFB09A2EDA99C0651
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61004.1.
RefSeqiWP_011270506.1. NC_007109.1.
YP_246169.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61004; AAY61004; RF_0153.
GeneIDi3401047.
KEGGirfe:RF_0153.
PATRICi17890660. VBIRicFel64634_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61004.1.
RefSeqiWP_011270506.1. NC_007109.1.
YP_246169.1. NC_007109.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KMSX-ray2.00A/B1-241[»]
ProteinModelPortaliQ4UN54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61004; AAY61004; RF_0153.
GeneIDi3401047.
KEGGirfe:RF_0153.
PATRICi17890660. VBIRicFel64634_0173.

Phylogenomic databases

KOiK00023.
OMAiNIANFEE.
OrthoDBiEOG6N3CR8.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-157-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011283. Acetoacetyl-CoA_reductase.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01829. AcAcCoA_reduct. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2Imported.
  2. "Crystal structure of Acetoacetyl-CoA reductase from Rickettsia felis."
    Seattle Structural Genomics Center for Infectious Disease (SSGCID)
    Abendroth J., Sankaran B., Davies D.R., Edwards T.E., Staker B.L.
    Submitted (MAY-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).

Entry informationi

Entry nameiQ4UN54_RICFE
AccessioniPrimary (citable) accession number: Q4UN54
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.