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Q4UN46 (TLCE_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 5
Alternative name(s):
ADP/ATP translocase 5
Gene names
Name:tlcE
Synonyms:tlc5
Ordered Locus Names:RF_0161
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499ADP,ATP carrier protein 5
PRO_0000286479

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane327 – 34721Helical; Potential
Transmembrane356 – 37621Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane468 – 48821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UN46 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 07701BA22105E10F

FASTA49956,856
        10         20         30         40         50         60 
MLSTSSRSFK SKFRAAFWPV HNYELGKFIP MSALMFCILF NQNILRILKD SILISEISAE 

        70         80         90        100        110        120 
IAGFAKVYCV TPAAALFVII YAKMINRFTF EKIFYYLSAF FISFFVLFAF VIYPNIHVFH 

       130        140        150        160        170        180 
VHPDNLADWM ERYPHFKWYI SLVGNWGYIV YYSLAELWPN IFYVLLFWQF ANELTTTEEA 

       190        200        210        220        230        240 
KRFYTFFSLF GNSSLILVGF LMMNLSSEDT IIKKFMSISD SKITLVQVST TIVAIVAIVC 

       250        260        270        280        290        300 
CVLVRFISKN VFTNPLFYAK AKSGRSTSER MGLIKSFKYI AKSKYLWLLL ICSAAFGFAI 

       310        320        330        340        350        360 
NLVEAVWKAK IKELYPTVNT YAEFNSLYIL WTGVAIMVMT IIGNNVMRMH NWFVAAVISP 

       370        380        390        400        410        420 
VIIMVTGILF FVLIVFDQQI LSLFDGAILM SPLALAVSIG GIQNILAKGT KYSIWDTSRE 

       430        440        450        460        470        480 
MLYIPLDDEL KTKGKAAVDV ISAKVGKSSS GLVQSIIFTL VPTATFTSIS PILMVVFTFV 

       490 
CLAWIYAVRK IYFEYQKIA 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61012.1.
RefSeqYP_246177.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61012; AAY61012; RF_0161.
GeneID3401055.
KEGGrfe:RF_0161.
PATRIC17890678. VBIRicFel64634_0182.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
KOK03301.
OMAMQHEREA.
OrthoDBEOG6BCSND.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-165-MONOMER.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCE_RICFE
AccessionPrimary (citable) accession number: Q4UN46
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names