Reviewed, UniProtKB/Swiss-Prot Q4UN46 (TLCE_RICFE)

Names and origin

Protein names

Recommended name:
    ADP,ATP carrier protein 5
Alternative name(s):
    ADP/ATP translocase 5

Gene names

Name:	tlcE
Synonyms:	tlc5
Ordered Locus Names:	RF_0161

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	499 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 499	499	ADP,ATP carrier protein 5		PRO_0000286479
Regions
	Transmembrane	25 – 45	21	Potential
	Transmembrane	61 – 81	21	Potential
	Transmembrane	93 – 113	21	Potential
	Transmembrane	148 – 168	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	223 – 243	21	Potential
	Transmembrane	286 – 306	21	Potential
	Transmembrane	327 – 347	21	Potential
	Transmembrane	356 – 376	21	Potential
	Transmembrane	380 – 400	21	Potential
	Transmembrane	468 – 488	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UN46-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 07701BA22105E10F	FASTA	499	56,856
	10 20 30 40 50 60 MLSTSSRSFK SKFRAAFWPV HNYELGKFIP MSALMFCILF NQNILRILKD SILISEISAE 70 80 90 100 110 120 IAGFAKVYCV TPAAALFVII YAKMINRFTF EKIFYYLSAF FISFFVLFAF VIYPNIHVFH 130 140 150 160 170 180 VHPDNLADWM ERYPHFKWYI SLVGNWGYIV YYSLAELWPN IFYVLLFWQF ANELTTTEEA 190 200 210 220 230 240 KRFYTFFSLF GNSSLILVGF LMMNLSSEDT IIKKFMSISD SKITLVQVST TIVAIVAIVC 250 260 270 280 290 300 CVLVRFISKN VFTNPLFYAK AKSGRSTSER MGLIKSFKYI AKSKYLWLLL ICSAAFGFAI 310 320 330 340 350 360 NLVEAVWKAK IKELYPTVNT YAEFNSLYIL WTGVAIMVMT IIGNNVMRMH NWFVAAVISP 370 380 390 400 410 420 VIIMVTGILF FVLIVFDQQI LSLFDGAILM SPLALAVSIG GIQNILAKGT KYSIWDTSRE 430 440 450 460 470 480 MLYIPLDDEL KTKGKAAVDV ISAKVGKSSS GLVQSIIFTL VPTATFTSIS PILMVVFTFV 490 CLAWIYAVRK IYFEYQKIA

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY61012.1.
RefSeq	YP_246177.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3401055.
GenomeReviews	Gene locus RF_0161 in contig CP000053_GR.
KEGG	rfe:RF_0161.
NMPDR	fig|315456.3.peg.680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UN46.
OMA	MMNLSSE
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0161-MON.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCE_RICFE

Accession

Primary (citable) accession number: Q4UN46

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2005
Last modified:	November 24, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)