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Protein

ADP,ATP carrier protein 5

Gene

tlcE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 5
Alternative name(s):
ADP/ATP translocase 5
Gene namesi
Name:tlcE
Synonyms:tlc5
Ordered Locus Names:RF_0161
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei223 – 24321HelicalSequence AnalysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence AnalysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Transmembranei468 – 48821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499ADP,ATP carrier protein 5PRO_0000286479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0161.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP/ATP translocase tlc family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3202.
HOGENOMiHOG000238123.
KOiK03301.
OMAiTSKEMLY.
OrthoDBiEOG6BCSND.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
[Graphical view]
PANTHERiPTHR31187:SF0. PTHR31187:SF0. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00769. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UN46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSTSSRSFK SKFRAAFWPV HNYELGKFIP MSALMFCILF NQNILRILKD
60 70 80 90 100
SILISEISAE IAGFAKVYCV TPAAALFVII YAKMINRFTF EKIFYYLSAF
110 120 130 140 150
FISFFVLFAF VIYPNIHVFH VHPDNLADWM ERYPHFKWYI SLVGNWGYIV
160 170 180 190 200
YYSLAELWPN IFYVLLFWQF ANELTTTEEA KRFYTFFSLF GNSSLILVGF
210 220 230 240 250
LMMNLSSEDT IIKKFMSISD SKITLVQVST TIVAIVAIVC CVLVRFISKN
260 270 280 290 300
VFTNPLFYAK AKSGRSTSER MGLIKSFKYI AKSKYLWLLL ICSAAFGFAI
310 320 330 340 350
NLVEAVWKAK IKELYPTVNT YAEFNSLYIL WTGVAIMVMT IIGNNVMRMH
360 370 380 390 400
NWFVAAVISP VIIMVTGILF FVLIVFDQQI LSLFDGAILM SPLALAVSIG
410 420 430 440 450
GIQNILAKGT KYSIWDTSRE MLYIPLDDEL KTKGKAAVDV ISAKVGKSSS
460 470 480 490
GLVQSIIFTL VPTATFTSIS PILMVVFTFV CLAWIYAVRK IYFEYQKIA
Length:499
Mass (Da):56,856
Last modified:July 5, 2005 - v1
Checksum:i07701BA22105E10F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61012.1.
RefSeqiWP_011270513.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61012; AAY61012; RF_0161.
KEGGirfe:RF_0161.
PATRICi17890678. VBIRicFel64634_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61012.1.
RefSeqiWP_011270513.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0161.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61012; AAY61012; RF_0161.
KEGGirfe:RF_0161.
PATRICi17890678. VBIRicFel64634_0182.

Phylogenomic databases

eggNOGiCOG3202.
HOGENOMiHOG000238123.
KOiK03301.
OMAiTSKEMLY.
OrthoDBiEOG6BCSND.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-165-MONOMER.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
[Graphical view]
PANTHERiPTHR31187:SF0. PTHR31187:SF0. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00769. AAA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTLCE_RICFE
AccessioniPrimary (citable) accession number: Q4UN46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.