Q4UMZ7 (LOLD_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein-releasing system ATP-binding protein LolD
EC=3.6.3.-

Gene names

Name:	lolD
Ordered Locus Names:	RF_0210

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner By similarity. HAMAP MF_01708
Subunit structure	The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01708.
Sequence similarities	Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro lipoprotein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Lipoprotein-releasing system ATP-binding protein LolD HAMAP MF_01708		PRO_0000260197
Regions
	Domain	6 – 220	215	ABC transporter
	Nucleotide binding	42 – 49	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UMZ7 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 6249B668481F350B	FASTA	221	24,673
	10 20 30 40 50 60 MNNTVLILKN ISKHYSQGKT IVRVLDDLNL TVNEGELIAI IGSSGSGKST LLHIAGLLDK 70 80 90 100 110 120 PTNGQVIIPN SKYQKYHLIR LHYLGFIYQQ HHLLKDFTAL ENVIMPRLIS GLDQKEAIED 130 140 150 160 170 180 ATKILDDLGL GKKLYNMPGE LSGGEQQRVA IARSLINKPK IILADEPTGN LDPKTTNEVF 190 200 210 220 NLFLKVAREQ NTAVIMVTHN HELAHKMDKL YKLKHGLLNI A

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61061.1.
RefSeq	YP_246226.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 1L2T based on UniProtKB Q58206.
ProteinModelPortal	Q4UMZ7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3401597.
GenomeReviews	Gene locus RF_0210 in contig CP000053_GR.
KEGG	rfe:RF_0210.
NMPDR	fig|315456.3.peg.44.
PATRIC	17890794. VBIRicFel64634_0239.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG758042.
OMA	ELAHKMD.
ProtClustDB	CLSK871039.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0210-MONOMER.
Family and domain databases
HAMAP	MF_01708. ABC_ATPase_LolD. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015854. ABC_transpr_LolD. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K09810.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51244. LOLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LOLD_RICFE

Accession

Primary (citable) accession number: Q4UMZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program