Reviewed, UniProtKB/Swiss-Prot Q4UMZ3 (Y214_RICFE)

Names and origin

Protein names

Recommended name:
    Putative export ATP-binding/permease protein RF_0214
    EC=3.6.3.-

Gene names

Ordered Locus Names:

RF_0214

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of an ABC transporter complex. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Domain	The ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Putative export ATP-binding/permease protein RF_0214		PRO_0000278657
Regions
	Transmembrane	21 – 41	21	Potential
	Transmembrane	61 – 81	21	Potential
	Transmembrane	135 – 155	21	Potential
	Transmembrane	158 – 178	21	Potential
	Transmembrane	242 – 262	21	Potential
	Transmembrane	277 – 297	21	Potential
	Domain	20 – 303	284	ABC transmembrane type-1
	Domain	336 – 572	237	ABC transporter
	Nucleotide binding	371 – 378	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4UMZ3-1 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 23A1B35F732EA3CA	FASTA	576	64,466
	10 20 30 40 50 60 MDIKLLYRLI KYLKFYKKDL IIVMISLLSV SASLLLIGSV FRNLVDNGLS QNHILSVDKS 70 80 90 100 110 120 ILYICLLIII LSIASFFRSY FINNVAEKAV NQIRKDAYSN LITYEIEEFE ELKIGDIISR 130 140 150 160 170 180 LTNDIDQIST LIVNFLSFFI RNSVMLIGGV TLMFFESFKL ASIVIITIPI LLIPLIKFGK 190 200 210 220 230 240 HVKALSKKAL ESKSLLASDI DETFNNIRAI YAFNNQTNKI TDFDTKLQNY LTYCKTRLKI 250 260 270 280 290 300 RALFFAISIA IIFLAITLVV WIGASDIVKG NLSAGQIISF IYYAIIAGFS SGGIFELLSE 310 320 330 340 350 360 IHLPLAALER IITIIDKTPI THNSYLELNN SDPISIEFKN VDFTYHSRPN LRIINNMSLK 370 380 390 400 410 420 INADKFIGIV GRSGGGKSTL MQLLLRFYRQ ESGTILINNQ DITLSNPAEI RKLIAYVPQE 430 440 450 460 470 480 ANIFSGTIKS NIIFGNTQAS DDDINEIIKI TGIEEFAAKL HDGINAKIGE RGVRLSGGQK 490 500 510 520 530 540 QRIAIARALL RKPQILLLDE AMSALDTMSE QKLLESIKEI MKGKIIISIA HRISSIESAD 550 560 570 YILVIDKGGV AASGSHNDLS KNSEIYRNIC REQLTV

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY61065.1. Different initiation.
RefSeq	YP_246230.1.
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ModBase	Search...
Genome annotation databases
GeneID	3400568.
GenomeReviews	Gene locus RF_0214 in contig CP000053_GR.
KEGG	rfe:RF_0214.
NMPDR	fig|315456.3.peg.48.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UMZ3.
OMA	GNNEAND
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0214-MON.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y214_RICFE

Accession

Primary (citable) accession number: Q4UMZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	November 24, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)