Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UMW4

- UBIE_RICFE

UniProt

Q4UMW4 - UBIE_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
  2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis, Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-250-MONOMER.
UniPathwayiUPA00079; UER00169.
UPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
Demethylmenaquinone methyltransferaseUniRule annotation
Gene namesi
Name:ubiEUniRule annotation
Ordered Locus Names:RF_0243
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEPRO_0000272374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0243.

Structurei

3D structure databases

ProteinModelPortaliQ4UMW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2226.
HOGENOMiHOG000249463.
KOiK03183.
OMAiIWKRFTI.
OrthoDBiEOG6M6JSB.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. UbiE_methyltran.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UMW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQTNFGFKK VDYTKKQGLV NSVFSNVADK YDLMNDLMSF GLHRLWKDEF
60 70 80 90 100
SRQIPNLNSH ILDVASGSGD IALKLAKKAR DRGNNIALTL SDINEEMLKN
110 120 130 140 150
AKKKAIDLNL FQNLKFTVAS AEELPFSDNS FDYYTIAFGI RNVPDINKAL
160 170 180 190 200
KEAYRVLKPM GKFICLEFSK VKESYFKDFY KFYSFSIIPT IGQAITGNKE
210 220 230 240
AYEYLVESIE LFPSQDEFRI MLKEAGFEEV SYKNLSGGIV AIHSAYKI
Length:248
Mass (Da):28,296
Last modified:July 5, 2005 - v1
Checksum:iFAE7B7FEC863471F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61094.1.
RefSeqiYP_246259.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61094; AAY61094; RF_0243.
GeneIDi3400692.
KEGGirfe:RF_0243.
PATRICi17890874. VBIRicFel64634_0278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61094.1 .
RefSeqi YP_246259.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UMW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0243.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61094 ; AAY61094 ; RF_0243 .
GeneIDi 3400692.
KEGGi rfe:RF_0243.
PATRICi 17890874. VBIRicFel64634_0278.

Phylogenomic databases

eggNOGi COG2226.
HOGENOMi HOG000249463.
KOi K03183.
OMAi IWKRFTI.
OrthoDBi EOG6M6JSB.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00169 .
UPA00232 .
BioCyci RFEL315456:GKEK-250-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01813. UbiE_methyltran.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view ]
Pfami PF01209. Ubie_methyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiUBIE_RICFE
AccessioniPrimary (citable) accession number: Q4UMW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3