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Q4UMW4

- UBIE_RICFE

UniProt

Q4UMW4 - UBIE_RICFE

Protein

Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

Gene

ubiE

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

    Catalytic activityi

    A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation
    S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
    2. ubiquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis, Ubiquinone biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-250-MONOMER.
    UniPathwayiUPA00079; UER00169.
    UPA00232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEUniRule annotation (EC:2.1.1.163UniRule annotation, EC:2.1.1.201UniRule annotation)
    Alternative name(s):
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylaseUniRule annotation
    Demethylmenaquinone methyltransferaseUniRule annotation
    Gene namesi
    Name:ubiEUniRule annotation
    Ordered Locus Names:RF_0243
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiEPRO_0000272374Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UMW4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2226.
    HOGENOMiHOG000249463.
    KOiK03183.
    OMAiIWKRFTI.
    OrthoDBiEOG6M6JSB.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01813. UbiE_methyltran.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view]
    PfamiPF01209. Ubie_methyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UMW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQTNFGFKK VDYTKKQGLV NSVFSNVADK YDLMNDLMSF GLHRLWKDEF    50
    SRQIPNLNSH ILDVASGSGD IALKLAKKAR DRGNNIALTL SDINEEMLKN 100
    AKKKAIDLNL FQNLKFTVAS AEELPFSDNS FDYYTIAFGI RNVPDINKAL 150
    KEAYRVLKPM GKFICLEFSK VKESYFKDFY KFYSFSIIPT IGQAITGNKE 200
    AYEYLVESIE LFPSQDEFRI MLKEAGFEEV SYKNLSGGIV AIHSAYKI 248
    Length:248
    Mass (Da):28,296
    Last modified:July 5, 2005 - v1
    Checksum:iFAE7B7FEC863471F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61094.1.
    RefSeqiYP_246259.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61094; AAY61094; RF_0243.
    GeneIDi3400692.
    KEGGirfe:RF_0243.
    PATRICi17890874. VBIRicFel64634_0278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61094.1 .
    RefSeqi YP_246259.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UMW4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61094 ; AAY61094 ; RF_0243 .
    GeneIDi 3400692.
    KEGGi rfe:RF_0243.
    PATRICi 17890874. VBIRicFel64634_0278.

    Phylogenomic databases

    eggNOGi COG2226.
    HOGENOMi HOG000249463.
    KOi K03183.
    OMAi IWKRFTI.
    OrthoDBi EOG6M6JSB.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00169 .
    UPA00232 .
    BioCyci RFEL315456:GKEK-250-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01813. UbiE_methyltran.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR004033. UbiE/COQ5_MeTrFase.
    IPR023576. UbiE/COQ5_MeTrFase_CS.
    [Graphical view ]
    Pfami PF01209. Ubie_methyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR01934. MenG_MenH_UbiE. 1 hit.
    PROSITEi PS51608. SAM_MT_UBIE. 1 hit.
    PS01183. UBIE_1. 1 hit.
    PS01184. UBIE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiUBIE_RICFE
    AccessioniPrimary (citable) accession number: Q4UMW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3