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Q4UMW4 (UBIE_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

EC=2.1.1.163
EC=2.1.1.201
Alternative name(s):
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Demethylmenaquinone methyltransferase
Gene names
Name:ubiE
Ordered Locus Names:RF_0243
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) By similarity. HAMAP-Rule MF_01813

Catalytic activity

A demethylmenaquinone + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. HAMAP-Rule MF_01813

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. HAMAP-Rule MF_01813

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 8/8. HAMAP-Rule MF_01813

Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01813

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
Ubiquinone biosynthesis
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

ubiquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionmethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE HAMAP-Rule MF_01813
PRO_0000272374

Sequences

Sequence LengthMass (Da)Tools
Q4UMW4 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: FAE7B7FEC863471F

FASTA24828,296
        10         20         30         40         50         60 
MNQTNFGFKK VDYTKKQGLV NSVFSNVADK YDLMNDLMSF GLHRLWKDEF SRQIPNLNSH 

        70         80         90        100        110        120 
ILDVASGSGD IALKLAKKAR DRGNNIALTL SDINEEMLKN AKKKAIDLNL FQNLKFTVAS 

       130        140        150        160        170        180 
AEELPFSDNS FDYYTIAFGI RNVPDINKAL KEAYRVLKPM GKFICLEFSK VKESYFKDFY 

       190        200        210        220        230        240 
KFYSFSIIPT IGQAITGNKE AYEYLVESIE LFPSQDEFRI MLKEAGFEEV SYKNLSGGIV 


AIHSAYKI 

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References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61094.1.
RefSeqYP_246259.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UMW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0243.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61094; AAY61094; RF_0243.
GeneID3400692.
KEGGrfe:RF_0243.
PATRIC17890874. VBIRicFel64634_0278.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2226.
HOGENOMHOG000249463.
KOK03183.
OMAIWKRFTI.
OrthoDBEOG6M6JSB.
ProtClustDBPRK00216.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-250-MONOMER.
UniPathwayUPA00079; UER00169.
UPA00232.

Family and domain databases

HAMAPMF_01813. UbiE_methyltran.
InterProIPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBIE_RICFE
AccessionPrimary (citable) accession number: Q4UMW4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: March 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways