Reviewed,
UniProtKB/Swiss-Prot Q4UMT4 (FUMC_RICFE)
Last modified
June 16, 2009.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fumarate hydratase class II Short name=Fumarase C EC=4.2.1.2 | ||||
| Gene names |
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| Organism | Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 42862 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group |
Protein attributes
| Sequence length | 461 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-malate = fumarate + H2O. HAMAP MF_00743 |
| Pathway | Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00743 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Miscellaneous | There are 2 substrate binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity. |
| Sequence similarities | Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Cytoplasm |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fumarate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycleInferred from electronic annotation. Source: HAMAP |
| Cellular component | tricarboxylic acid cycle enzyme complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | fumarate hydratase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 461 | 461 | Fumarate hydratase class II HAMAP MF_00743 | PRO_0000277939 | |||||
Regions | |||||||||
| Region | 129 – 132 | 4 | B site By similarity | ||||||
| Region | 139 – 141 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 100 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2. |
Cross-references
Sequence databases | |
|---|---|
| CP000053 Genomic DNA. Translation: AAY61124.1. | |
| RefSeq | YP_246289.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3400680. |
| GenomeReviews | Gene locus RF_0273 in contig CP000053_GR. |
| KEGG | rfe:RF_0273. |
| NMPDR | fig|315456.3.peg.107. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q4UMT4. |
| OMA | Q4UMT4. GSQGHFE. |
Enzyme and pathway databases | |
| BioCyc | RFEL315456:RF_0273-MON. |
| BRENDA | 4.2.1.2. 297363. |
Family and domain databases | |
| HAMAP | MF_00743. [Tree] |
| InterPro | IPR003031. D_crystallin. IPR005677. Fum_hydII. IPR018951. Fumarase_C_C. IPR000362. Fumarate_lyase. [Graphical view] |
| Pfam | PF10415. FumaraseC_C. 1 hit. PF00206. Lyase_1. 1 hit. [Graphical view] |
| PRINTS | PR00145. DCRYSTALLIN. PR00149. FUMRATELYASE. |
| TIGRFAMs | TIGR00979. fumC_II. 1 hit. |
| PROSITE | PS00163. FUMARATE_LYASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FUMC_RICFE | ||||||||
| Accession | Primary (citable) accession number: Q4UMT4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Rickettsia felis (Rickettsia azadi) Rickettsia felis (strain URRWXCal2): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


