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Q4UML8

- PUR7_RICFE

UniProt

Q4UML8 - PUR7_RICFE

Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-352-MONOMER.
    UniPathwayiUPA00074; UER00131.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
    Alternative name(s):
    SAICAR synthetaseUniRule annotation
    Gene namesi
    Name:purCUniRule annotation
    Ordered Locus Names:RF_0339
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_0000274848Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UML8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SAICAR synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0152.
    HOGENOMiHOG000082629.
    KOiK01923.
    OMAiVQYFKDD.
    OrthoDBiEOG62C9HN.

    Family and domain databases

    Gene3Di3.30.470.20. 1 hit.
    HAMAPiMF_00137. SAICAR_synth.
    InterProiIPR013816. ATP_grasp_subdomain_2.
    IPR028923. SAICAR_synt/ADE2_N.
    IPR001636. SAICAR_synth.
    [Graphical view]
    PfamiPF01259. SAICAR_synt. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UML8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTQLYKGSS KILYSAEEDF LLIMAFSDNV TLESGEIIEI SGKGVLNNNI    50
    SSFLMDKLEM NGIENHFIEK INMREQLIQY VEVFPVQVII SSVACGRFVK 100
    EFGMDEGYVF DKPIIDFKVR SREFKYPIVN EYQILNFGWL TRDEIKAVKE 150
    QALRIYDFLS GLFIGVGIRL VECKLEFGRV FNGEESIIML TDEISPDNCR 200
    LWHINSNEKL GFELLENEPN KAFESYQLIA DRLKEK 236
    Length:236
    Mass (Da):27,357
    Last modified:July 5, 2005 - v1
    Checksum:iFC3ECF9AEB1546E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61190.1.
    RefSeqiWP_011270682.1. NC_007109.1.
    YP_246355.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61190; AAY61190; RF_0339.
    GeneIDi3401279.
    KEGGirfe:RF_0339.
    PATRICi17891124. VBIRicFel64634_0396.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61190.1 .
    RefSeqi WP_011270682.1. NC_007109.1.
    YP_246355.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UML8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61190 ; AAY61190 ; RF_0339 .
    GeneIDi 3401279.
    KEGGi rfe:RF_0339.
    PATRICi 17891124. VBIRicFel64634_0396.

    Phylogenomic databases

    eggNOGi COG0152.
    HOGENOMi HOG000082629.
    KOi K01923.
    OMAi VQYFKDD.
    OrthoDBi EOG62C9HN.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00131 .
    BioCyci RFEL315456:GKEK-352-MONOMER.

    Family and domain databases

    Gene3Di 3.30.470.20. 1 hit.
    HAMAPi MF_00137. SAICAR_synth.
    InterProi IPR013816. ATP_grasp_subdomain_2.
    IPR028923. SAICAR_synt/ADE2_N.
    IPR001636. SAICAR_synth.
    [Graphical view ]
    Pfami PF01259. SAICAR_synt. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiPUR7_RICFE
    AccessioniPrimary (citable) accession number: Q4UML8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3