Q4UML8 (PUR7_RICFE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	RF_0339

Organism

Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

315456 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia felis

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP-Rule MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP-Rule MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP-Rule MF_00137		PRO_0000274848

Sequences

	Sequence		Length	Mass (Da)
	Q4UML8 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: FC3ECF9AEB1546E5	FASTA	236	27,357
	10 20 30 40 50 60 MKTQLYKGSS KILYSAEEDF LLIMAFSDNV TLESGEIIEI SGKGVLNNNI SSFLMDKLEM 70 80 90 100 110 120 NGIENHFIEK INMREQLIQY VEVFPVQVII SSVACGRFVK EFGMDEGYVF DKPIIDFKVR 130 140 150 160 170 180 SREFKYPIVN EYQILNFGWL TRDEIKAVKE QALRIYDFLS GLFIGVGIRL VECKLEFGRV 190 200 210 220 230 FNGEESIIML TDEISPDNCR LWHINSNEKL GFELLENEPN KAFESYQLIA DRLKEK

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000053 Genomic DNA. Translation: AAY61190.1.
RefSeq	YP_246355.1. NC_007109.1.
3D structure databases
HSSP	HSSP built from PDB template 2GQR based on UniProtKB P0A7D7.
ProteinModelPortal	Q4UML8.
ModBase	Search...
Protein-protein interaction databases
STRING	315456.RF_0339.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAY61190; AAY61190; RF_0339.
GeneID	3401279.
KEGG	rfe:RF_0339.
PATRIC	17891124. VBIRicFel64634_0396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HOG000082629.
KO	K01923.
OMA	VQYFKDD.
ProtClustDB	PRK09362.
Enzyme and pathway databases
UniPathway	UPA00074; UER00131.
Family and domain databases
Gene3D	3.30.470.20. 1 hit.
HAMAP	MF_00137. SAICAR_synth.
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. [Graphical view]
PANTHER	PTHR11609. PTHR11609. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_RICFE

Accession

Primary (citable) accession number: Q4UML8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program