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Q4UML8

- PUR7_RICFE

UniProt

Q4UML8 - PUR7_RICFE

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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-352-MONOMER.
UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:RF_0339
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Phosphoribosylaminoimidazole-succinocarboxamide synthasePRO_0000274848Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0339.

Structurei

3D structure databases

ProteinModelPortaliQ4UML8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0152.
HOGENOMiHOG000082629.
KOiK01923.
OMAiVQYFKDD.
OrthoDBiEOG62C9HN.

Family and domain databases

Gene3Di3.30.470.20. 1 hit.
HAMAPiMF_00137. SAICAR_synth.
InterProiIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
[Graphical view]
PfamiPF01259. SAICAR_synt. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UML8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTQLYKGSS KILYSAEEDF LLIMAFSDNV TLESGEIIEI SGKGVLNNNI
60 70 80 90 100
SSFLMDKLEM NGIENHFIEK INMREQLIQY VEVFPVQVII SSVACGRFVK
110 120 130 140 150
EFGMDEGYVF DKPIIDFKVR SREFKYPIVN EYQILNFGWL TRDEIKAVKE
160 170 180 190 200
QALRIYDFLS GLFIGVGIRL VECKLEFGRV FNGEESIIML TDEISPDNCR
210 220 230
LWHINSNEKL GFELLENEPN KAFESYQLIA DRLKEK
Length:236
Mass (Da):27,357
Last modified:July 5, 2005 - v1
Checksum:iFC3ECF9AEB1546E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61190.1.
RefSeqiYP_246355.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61190; AAY61190; RF_0339.
GeneIDi3401279.
KEGGirfe:RF_0339.
PATRICi17891124. VBIRicFel64634_0396.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61190.1 .
RefSeqi YP_246355.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UML8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61190 ; AAY61190 ; RF_0339 .
GeneIDi 3401279.
KEGGi rfe:RF_0339.
PATRICi 17891124. VBIRicFel64634_0396.

Phylogenomic databases

eggNOGi COG0152.
HOGENOMi HOG000082629.
KOi K01923.
OMAi VQYFKDD.
OrthoDBi EOG62C9HN.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00131 .
BioCyci RFEL315456:GKEK-352-MONOMER.

Family and domain databases

Gene3Di 3.30.470.20. 1 hit.
HAMAPi MF_00137. SAICAR_synth.
InterProi IPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
[Graphical view ]
Pfami PF01259. SAICAR_synt. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiPUR7_RICFE
AccessioniPrimary (citable) accession number: Q4UML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3