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Q4UML8 (PUR7_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase

EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:RF_0339
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP-Rule MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP-Rule MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP-Rule MF_00137
PRO_0000274848

Sequences

Sequence LengthMass (Da)Tools
Q4UML8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: FC3ECF9AEB1546E5

FASTA23627,357
        10         20         30         40         50         60 
MKTQLYKGSS KILYSAEEDF LLIMAFSDNV TLESGEIIEI SGKGVLNNNI SSFLMDKLEM 

        70         80         90        100        110        120 
NGIENHFIEK INMREQLIQY VEVFPVQVII SSVACGRFVK EFGMDEGYVF DKPIIDFKVR 

       130        140        150        160        170        180 
SREFKYPIVN EYQILNFGWL TRDEIKAVKE QALRIYDFLS GLFIGVGIRL VECKLEFGRV 

       190        200        210        220        230 
FNGEESIIML TDEISPDNCR LWHINSNEKL GFELLENEPN KAFESYQLIA DRLKEK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61190.1.
RefSeqYP_246355.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UML8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61190; AAY61190; RF_0339.
GeneID3401279.
KEGGrfe:RF_0339.
PATRIC17891124. VBIRicFel64634_0396.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHOG000082629.
KOK01923.
OMAVQYFKDD.
OrthoDBEOG62C9HN.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-352-MONOMER.
UniPathwayUPA00074; UER00131.

Family and domain databases

Gene3D3.30.470.20. 1 hit.
HAMAPMF_00137. SAICAR_synth.
InterProIPR013816. ATP_grasp_subdomain_2.
IPR028923. SAICAR_synt/ADE2_N.
IPR001636. SAICAR_synth.
[Graphical view]
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_RICFE
AccessionPrimary (citable) accession number: Q4UML8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways