SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4UMJ0

- MFD_RICFE

UniProt

Q4UMJ0 - MFD_RICFE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transcription-repair-coupling factor
Gene
mfd, RF_0367
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi605 – 6128ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: InterPro
  3. helicase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. transcription-coupled nucleotide-excision repair, DNA damage recognition Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription-repair-coupling factor (EC:3.6.4.-)
Short name:
TRCF
Gene namesi
Name:mfd
Ordered Locus Names:RF_0367
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11421142Transcription-repair-coupling factorUniRule annotation
PRO_0000281073Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0367.

Structurei

3D structure databases

ProteinModelPortaliQ4UMJ0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini592 – 757166Helicase ATP-binding
Add
BLAST
Domaini778 – 932155Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi710 – 7134DEEQ boxUniRule annotation

Sequence similaritiesi

In the N-terminal section; belongs to the UvrB family.
In the C-terminal section; belongs to the helicase family. RecG subfamily.

Phylogenomic databases

eggNOGiCOG1197.
HOGENOMiHOG000216592.
KOiK03723.
OMAiQVLEHGE.
OrthoDBiEOG6FNHKW.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00969. TRCF.
InterProiIPR003711. CarD-like/TRCF_domain.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR005118. TRCF_C.
[Graphical view]
PfamiPF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
[Graphical view]
SMARTiSM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
[Graphical view]
SUPFAMiSSF141259. SSF141259. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00580. mfd. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UMJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MLQQKFPATA KSFFATHNFT KNLKQDFILS SSNEDEALQL YKQALFFSSN     50
ENIYYFPSYD TIPYDHTSPN ANILSRRAEI LTKLTTNNSN GKLLITYAAN 100
LLNKLPPKDF FSKYFLKLSP KMKFTTDELA MFLVENSFTR NASSIDVGEF 150
AVRGEIIDII LPGPKAYRIN FSWDYIESIK EFDIDTQIST KSCSELVISP 200
ANEIVLNSET NGNFKNNYLR NFGVNHTDNP LYEAVISGRK FAGYEQLLPL 250
FYNSCSSLVD YLNDPIFIFD NLSKQAILEF EHSYNDFYSA RSEVNKLKFN 300
SFYPTLSPTD LYFTASEITE LLEQKNNIFI SYENSEQATL IENISSASFI 350
EKKTVFDKLF EIIKAHSSKK IVIGAASLSG LERIKSITQN YEYKYNEINK 400
LDEAKASVIN VGIIPLNQSF YTKEYLFITA SELLEEKSSS TNTNKKLKNI 450
LLELDNLAEG EFVVHKDHGI GQFLKLEALE IKGKLHDFLK ILYAGNDKLY 500
IPVENIEVIK KYGNDNAELD KLGSSSWQRS KAKLKNRIKE IALHLIQIAA 550
KRKLNSSASV EFDLEEYDKF CANFPFSETE DQLTAINDIK EDLRNGMLMD 600
RLICGDVGFG KTEVAMRAVF MVAKSLNEHL PQVAVVVPTT ILCSQHFSRF 650
IERFKGFGLN IKQLSSVISA KEAKIIRSEL ESGKINIIIG THSLLHKNTK 700
FFNLKLLIID EEQHFGVGQK EFLKSLKSSS HVLAMSATPI PRTLQMSMTG 750
LKELSIIATP PLNRLEVRTM VMPFDPVIIR DALLREHFRG GRSFYVVPRI 800
KDIEDIEKQL KQIVPELSYK IAHGKMTPSK IDEVMSEFYA GKFDILVSTT 850
IIESGIDIAE ANTMVIHKAD MLGLSQLYQL RGRIGRGKVR GYAYLTVASH 900
KKMTSHSLRR LEIIQNSCAL GSGFTIASHD MDLRGFGNLI GEEQSGQIKE 950
VGTELYQEML EEQIAIFKDE PIVSEQLFIP TINLGLSVFI PDNYISDSAL 1000
KLGLYRRIGN LSNEIEVEKF KDEMIDRFGS LPIEFNNLLD IVKIKLLCFK 1050
LNIENLDSGD NGFVIKFYKN ADMTDKILKF VSTYSNQAKI KPDNKLVYIK 1100
KLVDKNIIVE VNQLLWKLGG CRLDVIPNTS LRGAKRRGNL IK 1142
Length:1,142
Mass (Da):129,663
Last modified:July 5, 2005 - v1
Checksum:iCC689B86E2253EC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61218.1.
RefSeqiWP_011270706.1. NC_007109.1.
YP_246383.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61218; AAY61218; RF_0367.
GeneIDi3400360.
KEGGirfe:RF_0367.
PATRICi17891190. VBIRicFel64634_0429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61218.1 .
RefSeqi WP_011270706.1. NC_007109.1.
YP_246383.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UMJ0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 315456.RF_0367.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61218 ; AAY61218 ; RF_0367 .
GeneIDi 3400360.
KEGGi rfe:RF_0367.
PATRICi 17891190. VBIRicFel64634_0429.

Phylogenomic databases

eggNOGi COG1197.
HOGENOMi HOG000216592.
KOi K03723.
OMAi QVLEHGE.
OrthoDBi EOG6FNHKW.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-380-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00969. TRCF.
InterProi IPR003711. CarD-like/TRCF_domain.
IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR004576. Mfd.
IPR027417. P-loop_NTPase.
IPR005118. TRCF_C.
[Graphical view ]
Pfami PF02559. CarD_CdnL_TRCF. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF03461. TRCF. 1 hit.
[Graphical view ]
SMARTi SM01058. CarD_TRCF. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00982. TRCF. 1 hit.
[Graphical view ]
SUPFAMi SSF141259. SSF141259. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00580. mfd. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiMFD_RICFE
AccessioniPrimary (citable) accession number: Q4UMJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi