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Protein

Arp2/3 complex-activating protein rickA

Gene

rickA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Recruits and activates the Arp2/3 complex, which in turn leads to actin polymerization, promoting Rickettsia motility during infection.By similarity

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-384-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arp2/3 complex-activating protein rickA
Alternative name(s):
Actin polymerization protein rickA
Gene namesi
Name:rickA
Ordered Locus Names:RF_0371
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Arp2/3 complex-activating protein rickAPRO_0000259655Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi315456.RF_0371.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini383 – 40018WH2 1PROSITE-ProRule annotationAdd
BLAST
Domaini410 – 42718WH2 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni448 – 48437Central and acidic domainsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi319 – 35537Pro-richAdd
BLAST
Compositional biasi467 – 47913Poly-SerAdd
BLAST

Sequence similaritiesi

Contains 2 WH2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000010877.
OrthoDBiEOG6PCPSZ.

Family and domain databases

InterProiIPR003124. WH2_dom.
[Graphical view]
SMARTiSM00246. WH2. 2 hits.
[Graphical view]
PROSITEiPS51082. WH2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UMI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIDINKL LAQENNALNT ILSQVNELCE QNKKLQGLIE IQNETKELEK
60 70 80 90 100
EHNRSLPWFK RLVKTVSNVK YIFVKSEEQL TNEAIKYNNK ILKDIDNKIY
110 120 130 140 150
NIAEKSAPLK QELQEEIEKN FKDLTKKDLS KEQRERLSEV YFSYKSKPER
160 170 180 190 200
FSALNMTNPL QFIKAEELEK QYNSLNATKQ NIQNLISENS NIKELKEIQK
210 220 230 240 250
QVAEIREEIP YTFFEKLNNI WQNVKNVFVN NSEQVLAKNK ESNTRAIRKI
260 270 280 290 300
DEQLYKTKHK FEELIENKER NINDIIAKLP DNEELQKIVS NLANHMTSKK
310 320 330 340 350
EPILTTSSIA KPLENNVTPP PPLTKNNIPP PPPPPPLSKN NILPPPPPPM
360 370 380 390 400
PTMAPAQTET LSKPVGVTTT VKKLENQPRP SIDTSDLMRE IAGPKNLRKV
410 420 430 440 450
EKTDVKTQDS RDLLLQSIRG EHKLRKVEFD PNTGKPVAHS HSKPAQNVSK
460 470 480 490 500
PNGVASILAR RVAMEMSDSS SSSGSESDSG NWSDASVNSN KPKALKTRGE
510 520
RDAKTTTHAQ KILSNRSSQK PSFVRS
Length:526
Mass (Da):59,855
Last modified:October 31, 2006 - v2
Checksum:iF7AA7EDED7258F4A
GO

Sequence cautioni

The sequence AAY61222.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61222.1. Different initiation.
RefSeqiWP_039594871.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61222; AAY61222; RF_0371.
KEGGirfe:RF_0371.
PATRICi17891200. VBIRicFel64634_0434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61222.1. Different initiation.
RefSeqiWP_039594871.1. NC_007109.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315456.RF_0371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY61222; AAY61222; RF_0371.
KEGGirfe:RF_0371.
PATRICi17891200. VBIRicFel64634_0434.

Phylogenomic databases

HOGENOMiHOG000010877.
OrthoDBiEOG6PCPSZ.

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-384-MONOMER.

Family and domain databases

InterProiIPR003124. WH2_dom.
[Graphical view]
SMARTiSM00246. WH2. 2 hits.
[Graphical view]
PROSITEiPS51082. WH2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiRICKA_RICFE
AccessioniPrimary (citable) accession number: Q4UMI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 11, 2015
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.