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Q4UM78

- THYX_RICFE

UniProt

Q4UM78 - THYX_RICFE

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Protein

Thymidylate synthase ThyX

Gene
thyX, RF_0491
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+.UniRule annotation

Cofactori

Binds 1 FAD per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  2. thymidylate synthase (FAD) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-505-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase ThyX (EC:2.1.1.148)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyX
Ordered Locus Names:RF_0491
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Thymidylate synthase ThyXUniRule annotationPRO_0000272379Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0491.

Structurei

3D structure databases

ProteinModelPortaliQ4UM78.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 250224ThyXAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi96 – 10611ThyX motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1351.
HOGENOMiHOG000021807.
KOiK03465.
OMAiEIKFHIK.
OrthoDBiEOG661H77.

Family and domain databases

HAMAPiMF_01408. ThyX.
InterProiIPR003669. Thymidylate_synthase_ThyX.
[Graphical view]
PfamiPF02511. Thy1. 1 hit.
[Graphical view]
SUPFAMiSSF69796. SSF69796. 1 hit.
TIGRFAMsiTIGR02170. thyX. 1 hit.
PROSITEiPS51331. THYX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UM78-1 [UniParc]FASTAAdd to Basket

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MHNTTKRVTV PALEEILYEP IKVLDHGFIR VIDYMGDDSA IVQAARVSYG    50
KGTKQLNQDK GLINYLLRHY HTTPFEMCDI KFHIKLPIFI ARQWIRHRTA 100
SVNEYSARYS ILGNEFYLPE PANIASQSAV NKQCREGDSL PKEGAEKVLA 150
ILEEDAKQCY GHYKELMNAD EDGNIIDENN TGIARELARM NLTLNYYTEW 200
YWKINLHNLL HFLRLRADPH AQYEIRVYAE KMLEIVKAWV PFTYEAFEEY 250
RLQGANISRK GLDVIKRMIK GEKVTHESSG MTKREWEELM KIFG 294
Length:294
Mass (Da):34,308
Last modified:July 5, 2005 - v1
Checksum:iBFB8A315D6394E04
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61342.1.
RefSeqiYP_246507.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61342; AAY61342; RF_0491.
GeneIDi3401407.
KEGGirfe:RF_0491.
PATRICi17891484. VBIRicFel64634_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61342.1 .
RefSeqi YP_246507.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UM78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61342 ; AAY61342 ; RF_0491 .
GeneIDi 3401407.
KEGGi rfe:RF_0491.
PATRICi 17891484. VBIRicFel64634_0575.

Phylogenomic databases

eggNOGi COG1351.
HOGENOMi HOG000021807.
KOi K03465.
OMAi EIKFHIK.
OrthoDBi EOG661H77.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-505-MONOMER.

Family and domain databases

HAMAPi MF_01408. ThyX.
InterProi IPR003669. Thymidylate_synthase_ThyX.
[Graphical view ]
Pfami PF02511. Thy1. 1 hit.
[Graphical view ]
SUPFAMi SSF69796. SSF69796. 1 hit.
TIGRFAMsi TIGR02170. thyX. 1 hit.
PROSITEi PS51331. THYX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiTHYX_RICFE
AccessioniPrimary (citable) accession number: Q4UM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi