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Q4UM78

- THYX_RICFE

UniProt

Q4UM78 - THYX_RICFE

Protein

Thymidylate synthase ThyX

Gene

thyX

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP + NADPH = dTMP + tetrahydrofolate + NADP+.UniRule annotation

    Cofactori

    Binds 1 FAD per subunit.UniRule annotation

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    2. thymidylate synthase (FAD) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-505-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase ThyXUniRule annotation (EC:2.1.1.148UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyXUniRule annotation
    Ordered Locus Names:RF_0491
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294Thymidylate synthase ThyXPRO_0000272379Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UM78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 250224ThyXUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi96 – 10611ThyX motifAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thymidylate synthase ThyX family.UniRule annotation
    Contains 1 thyX (flavin-dependent thymidylate synthase) domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1351.
    HOGENOMiHOG000021807.
    KOiK03465.
    OMAiEIKFHIK.
    OrthoDBiEOG661H77.

    Family and domain databases

    HAMAPiMF_01408. ThyX.
    InterProiIPR003669. Thymidylate_synthase_ThyX.
    [Graphical view]
    PfamiPF02511. Thy1. 1 hit.
    [Graphical view]
    SUPFAMiSSF69796. SSF69796. 1 hit.
    TIGRFAMsiTIGR02170. thyX. 1 hit.
    PROSITEiPS51331. THYX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UM78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHNTTKRVTV PALEEILYEP IKVLDHGFIR VIDYMGDDSA IVQAARVSYG    50
    KGTKQLNQDK GLINYLLRHY HTTPFEMCDI KFHIKLPIFI ARQWIRHRTA 100
    SVNEYSARYS ILGNEFYLPE PANIASQSAV NKQCREGDSL PKEGAEKVLA 150
    ILEEDAKQCY GHYKELMNAD EDGNIIDENN TGIARELARM NLTLNYYTEW 200
    YWKINLHNLL HFLRLRADPH AQYEIRVYAE KMLEIVKAWV PFTYEAFEEY 250
    RLQGANISRK GLDVIKRMIK GEKVTHESSG MTKREWEELM KIFG 294
    Length:294
    Mass (Da):34,308
    Last modified:July 5, 2005 - v1
    Checksum:iBFB8A315D6394E04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61342.1.
    RefSeqiYP_246507.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61342; AAY61342; RF_0491.
    GeneIDi3401407.
    KEGGirfe:RF_0491.
    PATRICi17891484. VBIRicFel64634_0575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61342.1 .
    RefSeqi YP_246507.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UM78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61342 ; AAY61342 ; RF_0491 .
    GeneIDi 3401407.
    KEGGi rfe:RF_0491.
    PATRICi 17891484. VBIRicFel64634_0575.

    Phylogenomic databases

    eggNOGi COG1351.
    HOGENOMi HOG000021807.
    KOi K03465.
    OMAi EIKFHIK.
    OrthoDBi EOG661H77.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-505-MONOMER.

    Family and domain databases

    HAMAPi MF_01408. ThyX.
    InterProi IPR003669. Thymidylate_synthase_ThyX.
    [Graphical view ]
    Pfami PF02511. Thy1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69796. SSF69796. 1 hit.
    TIGRFAMsi TIGR02170. thyX. 1 hit.
    PROSITEi PS51331. THYX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiTHYX_RICFE
    AccessioniPrimary (citable) accession number: Q4UM78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3