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Q4UM71 (SYH_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:RF_0498
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136239

Sequences

Sequence LengthMass (Da)Tools
Q4UM71 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 389AFF4E7A04DA1F

FASTA41547,486
        10         20         30         40         50         60 
MTEKLQPLRG MKDLLPDDYK VHDYIINKAR DVGVLYGYKQ MSIPILEYTK VFNRSMGESS 

        70         80         90        100        110        120 
DVISKEIYSF LDKSNESVAL RPEFTAGIIR SFISNGLQHK LPLKFFSTGP VFRYDRPQAG 

       130        140        150        160        170        180 
RQRQFHQLNY EYIGAKGAIT DAETLKLAVD ILKALEIEQD TILELNSLGC SESRSVYQQK 

       190        200        210        220        230        240 
LVEYLNDFKD QLSEESKIRL TKNPMRILDS KSEIDQKIIA AAPILSEYYT DESKEYFEEL 

       250        260        270        280        290        300 
IKYLDILGVK YVINPRLVRG LDYYCHTAFE FTTKKLGSQS TILAGGRYDG LAKIMGNNDD 

       310        320        330        340        350        360 
VPAIGFAAGI ERIALMREYN ISEVKPVFVL PIGENNICYA LEIVDKLRLQ NISTIIDPVG 

       370        380        390        400        410 
KIAKRIQRVL NENAKFIIFI GDEEQANNSL KLKDLEKKEE YIVDFAKVLE LLKKY 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61349.1.
RefSeqYP_246514.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4UM71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0498.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61349; AAY61349; RF_0498.
GeneID3401160.
KEGGrfe:RF_0498.
PATRIC17891506. VBIRicFel64634_0586.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018072.
KOK01892.
OMACGGGNFK.
OrthoDBEOG6BPDH4.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-512-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_RICFE
AccessionPrimary (citable) accession number: Q4UM71
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries