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Q4UM53

- HSLU_RICFE

UniProt

Q4UM53 - HSLU_RICFE

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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei261 – 2611ATPUniRule annotation
Binding sitei328 – 3281ATPUniRule annotation
Binding sitei400 – 4001ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 766ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. peptidase activity, acting on L-amino acid peptides Source: InterPro

GO - Biological processi

  1. protein unfolding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:RF_0516
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. HslUV protease complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450ATP-dependent protease ATPase subunit HslUPRO_0000277981Add
BLAST

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0516.

Structurei

3D structure databases

ProteinModelPortaliQ4UM53.
SMRiQ4UM53. Positions 14-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1220.
HOGENOMiHOG000010036.
KOiK03667.
OMAiPVGVEIM.
OrthoDBiEOG6NPM7G.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00249. HslU.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00390. hslU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UM53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKATKTTYKK DPMGLTPSQI VNELNRFIVG QEKAKKAVAI ALRNRCRRKR
60 70 80 90 100
VEGNLRNEIV PKNILMIGST GVGKTEIARR LAKLTNSPFY KIEATKFTEV
110 120 130 140 150
GYVGRDVESI IRDLVEIAVN TKKTLAKMEV DINAREKAIE RILDSLVGKT
160 170 180 190 200
SSSETREKFK EKILNGKLDD TEIEISVADT TPVGGGSFEI PGMPGASMGV
210 220 230 240 250
LNLGDMIGRA LGSSKTKTKK MLVKDAMAII IPEESEKLID QEKIIQQAIN
260 270 280 290 300
LAENDGIVFI DEIDKIASTG SSGAKNAEIS REGVQRDLLP LIEGTTVNTK
310 320 330 340 350
YGPVKTDHIL FIASGAFHIA KPSDLLPELQ GRLPIRVELN SLTKDDMIKI
360 370 380 390 400
LLEPETSLVK QYSALIGTED VHLEFAASAI EKIADYAITV NLEVEDIGAR
410 420 430 440 450
RLHTILENLL EDISFEASEM KGKKITIDDK FVENQLSKII TNLDLAKFVL
Length:450
Mass (Da):49,557
Last modified:July 5, 2005 - v1
Checksum:iB9CC42EEA48D1D9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61367.1.
RefSeqiYP_246532.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61367; AAY61367; RF_0516.
GeneIDi3401178.
KEGGirfe:RF_0516.
PATRICi17891552. VBIRicFel64634_0609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61367.1 .
RefSeqi YP_246532.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4UM53.
SMRi Q4UM53. Positions 14-450.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61367 ; AAY61367 ; RF_0516 .
GeneIDi 3401178.
KEGGi rfe:RF_0516.
PATRICi 17891552. VBIRicFel64634_0609.

Phylogenomic databases

eggNOGi COG1220.
HOGENOMi HOG000010036.
KOi K03667.
OMAi PVGVEIM.
OrthoDBi EOG6NPM7G.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-530-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00249. HslU.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004491. HslU.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00390. hslU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiHSLU_RICFE
AccessioniPrimary (citable) accession number: Q4UM53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3