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Q4UM53

- HSLU_RICFE

UniProt

Q4UM53 - HSLU_RICFE

Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei328 – 3281ATPUniRule annotation
    Binding sitei400 – 4001ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi71 – 766ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. peptidase activity, acting on L-amino acid peptides Source: InterPro

    GO - Biological processi

    1. protein unfolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-530-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent protease ATPase subunit HslUUniRule annotation
    Alternative name(s):
    Unfoldase HslUUniRule annotation
    Gene namesi
    Name:hslUUniRule annotation
    Ordered Locus Names:RF_0516
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. HslUV protease complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450ATP-dependent protease ATPase subunit HslUPRO_0000277981Add
    BLAST

    Interactioni

    Subunit structurei

    A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4UM53.
    SMRiQ4UM53. Positions 14-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1220.
    HOGENOMiHOG000010036.
    KOiK03667.
    OMAiPVGVEIM.
    OrthoDBiEOG6NPM7G.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00249. HslU.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11262:SF3. PTHR11262:SF3. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00390. hslU. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4UM53-1 [UniParc]FASTAAdd to Basket

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    MKATKTTYKK DPMGLTPSQI VNELNRFIVG QEKAKKAVAI ALRNRCRRKR    50
    VEGNLRNEIV PKNILMIGST GVGKTEIARR LAKLTNSPFY KIEATKFTEV 100
    GYVGRDVESI IRDLVEIAVN TKKTLAKMEV DINAREKAIE RILDSLVGKT 150
    SSSETREKFK EKILNGKLDD TEIEISVADT TPVGGGSFEI PGMPGASMGV 200
    LNLGDMIGRA LGSSKTKTKK MLVKDAMAII IPEESEKLID QEKIIQQAIN 250
    LAENDGIVFI DEIDKIASTG SSGAKNAEIS REGVQRDLLP LIEGTTVNTK 300
    YGPVKTDHIL FIASGAFHIA KPSDLLPELQ GRLPIRVELN SLTKDDMIKI 350
    LLEPETSLVK QYSALIGTED VHLEFAASAI EKIADYAITV NLEVEDIGAR 400
    RLHTILENLL EDISFEASEM KGKKITIDDK FVENQLSKII TNLDLAKFVL 450
    Length:450
    Mass (Da):49,557
    Last modified:July 5, 2005 - v1
    Checksum:iB9CC42EEA48D1D9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61367.1.
    RefSeqiYP_246532.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61367; AAY61367; RF_0516.
    GeneIDi3401178.
    KEGGirfe:RF_0516.
    PATRICi17891552. VBIRicFel64634_0609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61367.1 .
    RefSeqi YP_246532.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4UM53.
    SMRi Q4UM53. Positions 14-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61367 ; AAY61367 ; RF_0516 .
    GeneIDi 3401178.
    KEGGi rfe:RF_0516.
    PATRICi 17891552. VBIRicFel64634_0609.

    Phylogenomic databases

    eggNOGi COG1220.
    HOGENOMi HOG000010036.
    KOi K03667.
    OMAi PVGVEIM.
    OrthoDBi EOG6NPM7G.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-530-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00249. HslU.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004491. HslU.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11262:SF3. PTHR11262:SF3. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00390. hslU. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiHSLU_RICFE
    AccessioniPrimary (citable) accession number: Q4UM53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3