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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:RF_0529
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002373961 – 447Glutamate--tRNA ligase 1Add BLAST447

Proteomic databases

PRIDEiQ4UM43

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0529

Structurei

3D structure databases

ProteinModelPortaliQ4UM43
SMRiQ4UM43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi240 – 244"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252721
KOiK01885
OMAiLYPCYET
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q4UM43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKIITRFAP SPTGMLHVGN IRAALLNWLY AKKHNGQFIL RFDDTDLERS
60 70 80 90 100
KQEYKDAIEE DLKFLNLNWD QTFNQLSRLS RYDEIKNLLL DKKRLYACYE
110 120 130 140 150
TPEELELKRK FQLSKGLPPI YDRASLNLTE EQTQKYIEQG RKPHYRFLVN
160 170 180 190 200
HEPISWHDMI KGEVKYDGKA LSEPIVIRAD GSMTYMLCSV IDDIDYDITH
210 220 230 240 250
IIRGEDHVSN TAIQIQMFEA LNTTPPTFGH LSLIINKDEK ISKRVGGFEI
260 270 280 290 300
TTLRKEIGLE AMAIASFFSL LGSSAQILPY KSMEKLANQF EISSFSKSPT
310 320 330 340 350
IYQPEDLERL NHKLLISLDF DEVKNHLKEI DAEYIDENFW LSVRPNLQKL
360 370 380 390 400
RDVKDWWEIC HKTPNVKSLN LDKEYLKQAA EVLPQGKITK DSWSIWTKEI
410 420 430 440
TNITGKKGKE LFLPLRLALT GRESGPEIAS VLPLIDREEI IKRLTSA
Length:447
Mass (Da):51,807
Last modified:July 5, 2005 - v1
Checksum:i55F40BD252E83667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA Translation: AAY61380.1
RefSeqiWP_011270861.1, NC_007109.1

Genome annotation databases

EnsemblBacteriaiAAY61380; AAY61380; RF_0529
KEGGirfe:RF_0529

Similar proteinsi

Entry informationi

Entry nameiSYE1_RICFE
AccessioniPrimary (citable) accession number: Q4UM43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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