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Q4UM22

- COXX_RICFE

UniProt

Q4UM22 - COXX_RICFE

Protein

Protoheme IX farnesyltransferase

Gene

ctaB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. heme O biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-564-MONOMER.
    UniPathwayiUPA00834; UER00712.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
    Alternative name(s):
    Heme B farnesyltransferaseUniRule annotation
    Heme O synthaseUniRule annotation
    Gene namesi
    Name:ctaBUniRule annotation
    Ordered Locus Names:RF_0550
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Protoheme IX farnesyltransferasePRO_0000274893Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi315456.RF_0550.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalUniRule annotationAdd
    BLAST
    Transmembranei52 – 7221HelicalUniRule annotationAdd
    BLAST
    Transmembranei102 – 11918HelicalUniRule annotationAdd
    BLAST
    Transmembranei123 – 14523HelicalUniRule annotationAdd
    BLAST
    Transmembranei151 – 17121HelicalUniRule annotationAdd
    BLAST
    Transmembranei179 – 19921HelicalUniRule annotationAdd
    BLAST
    Transmembranei225 – 24521HelicalUniRule annotationAdd
    BLAST
    Transmembranei247 – 26721HelicalUniRule annotationAdd
    BLAST
    Transmembranei284 – 30421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0109.
    HOGENOMiHOG000237291.
    KOiK02301.
    OMAiFKYSIGY.
    OrthoDBiEOG6DVJQB.

    Family and domain databases

    HAMAPiMF_00154. CyoE_CtaB.
    InterProiIPR006369. Protohaem_IX_farnesylTrfase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view]
    PfamiPF01040. UbiA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
    PROSITEiPS00943. UBIA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UM22-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSLVTPINL DKINHSQSTV KDYILLMKPR VMSLVIFTGF VGIWLAPYSV    50
    HPFIAGIAVV CIALGAGSAG AINMWYDRDI DSLMKRTQKR PIVRGAIEPD 100
    EALSFGLITG FFAVFFMALC VNLLASFLLL FTIFYYICIY TIWLKRRSIQ 150
    NIVIGGVSGA LPPVIGYAAV SNTISLESII LFLIIFIWTP PHSWALALFC 200
    NDDYKNCKVP MMPAVKGNLY TKKQILIYSI LLFIVSLMPF FIGMNNFIYL 250
    ITSGILGLVF LYYSGSLFYD TPDNKQAKRF FAYSIFYLFF IFLLLSSTST 300
    ISLIS 305
    Length:305
    Mass (Da):34,261
    Last modified:July 5, 2005 - v1
    Checksum:iE51B64737D984DB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61401.1.
    RefSeqiYP_246566.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61401; AAY61401; RF_0550.
    GeneIDi3400329.
    KEGGirfe:RF_0550.
    PATRICi17891640. VBIRicFel64634_0653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61401.1 .
    RefSeqi YP_246566.1. NC_007109.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61401 ; AAY61401 ; RF_0550 .
    GeneIDi 3400329.
    KEGGi rfe:RF_0550.
    PATRICi 17891640. VBIRicFel64634_0653.

    Phylogenomic databases

    eggNOGi COG0109.
    HOGENOMi HOG000237291.
    KOi K02301.
    OMAi FKYSIGY.
    OrthoDBi EOG6DVJQB.

    Enzyme and pathway databases

    UniPathwayi UPA00834 ; UER00712 .
    BioCyci RFEL315456:GKEK-564-MONOMER.

    Family and domain databases

    HAMAPi MF_00154. CyoE_CtaB.
    InterProi IPR006369. Protohaem_IX_farnesylTrfase.
    IPR000537. UbiA_prenyltransferase.
    [Graphical view ]
    Pfami PF01040. UbiA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
    PROSITEi PS00943. UBIA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiCOXX_RICFE
    AccessioniPrimary (citable) accession number: Q4UM22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3