Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protoheme IX farnesyltransferase

Gene

ctaB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Pathwayi: heme O biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme O from protoheme.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Protoheme IX farnesyltransferase (ctaB)
This subpathway is part of the pathway heme O biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme O from protoheme, the pathway heme O biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processHeme biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:ctaBUniRule annotation
Ordered Locus Names:RF_0550
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000008548 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei102 – 119HelicalUniRule annotationAdd BLAST18
Transmembranei123 – 145HelicalUniRule annotationAdd BLAST23
Transmembranei151 – 171HelicalUniRule annotationAdd BLAST21
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748931 – 305Protoheme IX farnesyltransferaseAdd BLAST305

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0550.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105F1R. Bacteria.
COG0109. LUCA.
HOGENOMiHOG000237291.
KOiK02301.
OMAiWQFPHFW.
OrthoDBiPOG091H05F2.

Family and domain databases

CDDicd13957. PT_UbiA_Cox10. 1 hit.
HAMAPiMF_00154. CyoE_CtaB. 1 hit.
InterProiView protein in InterPro
IPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
PfamiView protein in Pfam
PF01040. UbiA. 1 hit.
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiView protein in PROSITE
PS00943. UBIA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4UM22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLVTPINL DKINHSQSTV KDYILLMKPR VMSLVIFTGF VGIWLAPYSV
60 70 80 90 100
HPFIAGIAVV CIALGAGSAG AINMWYDRDI DSLMKRTQKR PIVRGAIEPD
110 120 130 140 150
EALSFGLITG FFAVFFMALC VNLLASFLLL FTIFYYICIY TIWLKRRSIQ
160 170 180 190 200
NIVIGGVSGA LPPVIGYAAV SNTISLESII LFLIIFIWTP PHSWALALFC
210 220 230 240 250
NDDYKNCKVP MMPAVKGNLY TKKQILIYSI LLFIVSLMPF FIGMNNFIYL
260 270 280 290 300
ITSGILGLVF LYYSGSLFYD TPDNKQAKRF FAYSIFYLFF IFLLLSSTST

ISLIS
Length:305
Mass (Da):34,261
Last modified:July 5, 2005 - v1
Checksum:iE51B64737D984DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61401.1.
RefSeqiWP_011270882.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61401; AAY61401; RF_0550.
KEGGirfe:RF_0550.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCOXX_RICFE
AccessioniPrimary (citable) accession number: Q4UM22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: June 7, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families