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Q4UM22

- COXX_RICFE

UniProt

Q4UM22 - COXX_RICFE

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Protein

Protoheme IX farnesyltransferase

Gene

ctaB

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. heme O biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-564-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
Heme B farnesyltransferaseUniRule annotation
Heme O synthaseUniRule annotation
Gene namesi
Name:ctaBUniRule annotation
Ordered Locus Names:RF_0550
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalUniRule annotationAdd
BLAST
Transmembranei52 – 7221HelicalUniRule annotationAdd
BLAST
Transmembranei102 – 11918HelicalUniRule annotationAdd
BLAST
Transmembranei123 – 14523HelicalUniRule annotationAdd
BLAST
Transmembranei151 – 17121HelicalUniRule annotationAdd
BLAST
Transmembranei179 – 19921HelicalUniRule annotationAdd
BLAST
Transmembranei225 – 24521HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26721HelicalUniRule annotationAdd
BLAST
Transmembranei284 – 30421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Protoheme IX farnesyltransferasePRO_0000274893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0550.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiFKYSIGY.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UM22-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLVTPINL DKINHSQSTV KDYILLMKPR VMSLVIFTGF VGIWLAPYSV
60 70 80 90 100
HPFIAGIAVV CIALGAGSAG AINMWYDRDI DSLMKRTQKR PIVRGAIEPD
110 120 130 140 150
EALSFGLITG FFAVFFMALC VNLLASFLLL FTIFYYICIY TIWLKRRSIQ
160 170 180 190 200
NIVIGGVSGA LPPVIGYAAV SNTISLESII LFLIIFIWTP PHSWALALFC
210 220 230 240 250
NDDYKNCKVP MMPAVKGNLY TKKQILIYSI LLFIVSLMPF FIGMNNFIYL
260 270 280 290 300
ITSGILGLVF LYYSGSLFYD TPDNKQAKRF FAYSIFYLFF IFLLLSSTST

ISLIS
Length:305
Mass (Da):34,261
Last modified:July 5, 2005 - v1
Checksum:iE51B64737D984DB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61401.1.
RefSeqiYP_246566.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61401; AAY61401; RF_0550.
GeneIDi3400329.
KEGGirfe:RF_0550.
PATRICi17891640. VBIRicFel64634_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61401.1 .
RefSeqi YP_246566.1. NC_007109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61401 ; AAY61401 ; RF_0550 .
GeneIDi 3400329.
KEGGi rfe:RF_0550.
PATRICi 17891640. VBIRicFel64634_0653.

Phylogenomic databases

eggNOGi COG0109.
HOGENOMi HOG000237291.
KOi K02301.
OMAi FKYSIGY.
OrthoDBi EOG6DVJQB.

Enzyme and pathway databases

UniPathwayi UPA00834 ; UER00712 .
BioCyci RFEL315456:GKEK-564-MONOMER.

Family and domain databases

HAMAPi MF_00154. CyoE_CtaB.
InterProi IPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCOXX_RICFE
AccessioniPrimary (citable) accession number: Q4UM22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3