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Q4UM22

- COXX_RICFE

UniProt

Q4UM22 - COXX_RICFE

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Protein

Protoheme IX farnesyltransferase

Gene
ctaB, RF_0550
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. protoheme IX farnesyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. heme O biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-564-MONOMER.
UniPathwayiUPA00834; UER00712.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoheme IX farnesyltransferase (EC:2.5.1.-)
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
Gene namesi
Name:ctaB
Ordered Locus Names:RF_0550
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Transmembranei102 – 11918Helical; Reviewed predictionAdd
BLAST
Transmembranei123 – 14523Helical; Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Transmembranei179 – 19921Helical; Reviewed predictionAdd
BLAST
Transmembranei225 – 24521Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST
Transmembranei284 – 30421Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Protoheme IX farnesyltransferaseUniRule annotationPRO_0000274893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi315456.RF_0550.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0109.
HOGENOMiHOG000237291.
KOiK02301.
OMAiFKYSIGY.
OrthoDBiEOG6DVJQB.

Family and domain databases

HAMAPiMF_00154. CyoE_CtaB.
InterProiIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01473. cyoE_ctaB. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UM22-1 [UniParc]FASTAAdd to Basket

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MSSLVTPINL DKINHSQSTV KDYILLMKPR VMSLVIFTGF VGIWLAPYSV    50
HPFIAGIAVV CIALGAGSAG AINMWYDRDI DSLMKRTQKR PIVRGAIEPD 100
EALSFGLITG FFAVFFMALC VNLLASFLLL FTIFYYICIY TIWLKRRSIQ 150
NIVIGGVSGA LPPVIGYAAV SNTISLESII LFLIIFIWTP PHSWALALFC 200
NDDYKNCKVP MMPAVKGNLY TKKQILIYSI LLFIVSLMPF FIGMNNFIYL 250
ITSGILGLVF LYYSGSLFYD TPDNKQAKRF FAYSIFYLFF IFLLLSSTST 300
ISLIS 305
Length:305
Mass (Da):34,261
Last modified:July 5, 2005 - v1
Checksum:iE51B64737D984DB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61401.1.
RefSeqiYP_246566.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61401; AAY61401; RF_0550.
GeneIDi3400329.
KEGGirfe:RF_0550.
PATRICi17891640. VBIRicFel64634_0653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61401.1 .
RefSeqi YP_246566.1. NC_007109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0550.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61401 ; AAY61401 ; RF_0550 .
GeneIDi 3400329.
KEGGi rfe:RF_0550.
PATRICi 17891640. VBIRicFel64634_0653.

Phylogenomic databases

eggNOGi COG0109.
HOGENOMi HOG000237291.
KOi K02301.
OMAi FKYSIGY.
OrthoDBi EOG6DVJQB.

Enzyme and pathway databases

UniPathwayi UPA00834 ; UER00712 .
BioCyci RFEL315456:GKEK-564-MONOMER.

Family and domain databases

HAMAPi MF_00154. CyoE_CtaB.
InterProi IPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view ]
Pfami PF01040. UbiA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01473. cyoE_ctaB. 1 hit.
PROSITEi PS00943. UBIA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiCOXX_RICFE
AccessioniPrimary (citable) accession number: Q4UM22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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