Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4UM22 (COXX_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoheme IX farnesyltransferase

EC=2.5.1.-
Alternative name(s):
Heme B farnesyltransferase
Heme O synthase
Gene names
Name:ctaB
Ordered Locus Names:RF_0550
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group By similarity. HAMAP-Rule MF_00154

Pathway

Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1. HAMAP-Rule MF_00154

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_00154.

Miscellaneous

Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature By similarity.

Sequence similarities

Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme O biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotoheme IX farnesyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Protoheme IX farnesyltransferase HAMAP-Rule MF_00154
PRO_0000274893

Regions

Transmembrane31 – 5121Helical; Potential
Transmembrane52 – 7221Helical; Potential
Transmembrane102 – 11918Helical; Potential
Transmembrane123 – 14523Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane284 – 30421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q4UM22 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: E51B64737D984DB1

FASTA30534,261
        10         20         30         40         50         60 
MSSLVTPINL DKINHSQSTV KDYILLMKPR VMSLVIFTGF VGIWLAPYSV HPFIAGIAVV 

        70         80         90        100        110        120 
CIALGAGSAG AINMWYDRDI DSLMKRTQKR PIVRGAIEPD EALSFGLITG FFAVFFMALC 

       130        140        150        160        170        180 
VNLLASFLLL FTIFYYICIY TIWLKRRSIQ NIVIGGVSGA LPPVIGYAAV SNTISLESII 

       190        200        210        220        230        240 
LFLIIFIWTP PHSWALALFC NDDYKNCKVP MMPAVKGNLY TKKQILIYSI LLFIVSLMPF 

       250        260        270        280        290        300 
FIGMNNFIYL ITSGILGLVF LYYSGSLFYD TPDNKQAKRF FAYSIFYLFF IFLLLSSTST 


ISLIS 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61401.1.
RefSeqYP_246566.1. NC_007109.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61401; AAY61401; RF_0550.
GeneID3400329.
KEGGrfe:RF_0550.
PATRIC17891640. VBIRicFel64634_0653.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0109.
HOGENOMHOG000237291.
KOK02301.
OMAGMWTLYT.
OrthoDBEOG6DVJQB.
ProtClustDBPRK04375.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-564-MONOMER.
UniPathwayUPA00834; UER00712.

Family and domain databases

HAMAPMF_00154. CyoE_CtaB.
InterProIPR006369. Protohaem_IX_farnesylTrfase.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsTIGR01473. cyoE_ctaB. 1 hit.
PROSITEPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOXX_RICFE
AccessionPrimary (citable) accession number: Q4UM22
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways