Reviewed, UniProtKB/Swiss-Prot Q4UM07 (NUOC_RICFE)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C
    NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	RF_0565

Organism

Rickettsia felis (Rickettsia azadi) [Complete proteome] [HAMAP]

Taxonomic identifier

42862 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD+ + quinol. HAMAP MF_01357
Subunit structure	NDH-1 is composed of 14 different subunits. Subunits nuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: HAMAP photosynthesis, light reaction Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	NADH-quinone oxidoreductase subunit C HAMAP MF_01357		PRO_0000287859

Sequences

	Sequence		Length	Mass (Da)
	Q4UM07-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: DD092E30E558D59A	FASTA	207	24,256
	10 20 30 40 50 60 MTLDKLIEKL AAKSSILITP IIVKDYLAYQ VEPNFLLPFL KALKESEELR FTVLTDLFGT 70 80 90 100 110 120 DFPERDKRFE VIYNLLSLKL NKRLIIKVYI SEKETIPSAM NIFNASCWYE REVYDMYGVN 130 140 150 160 170 180 FDGNDDKRRI LTDYEFEGHP LRKDFPLTGY TQVKYDEKLK KVAYEPVDLD IEYREFDFSS 190 200 HWHSPSYVLP GDEKATDVIP AKAGIQK

References

[1]

"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite." Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D. PLoS Biol. 3:1-12(2005) [PubMed: 15984913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000053 Genomic DNA. Translation: AAY61416.1.
RefSeq	YP_246581.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3400344.
GenomeReviews	Gene locus RF_0565 in contig CP000053_GR.
KEGG	rfe:RF_0565.
NMPDR	fig|315456.3.peg.399.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4UM07.
OMA	Q4UM07. LTGYTQV.
Enzyme and pathway databases
BioCyc	RFEL315456:RF_0565-MON.
BRENDA	1.6.99.5. 297363.
Family and domain databases
HAMAP	MF_01357. [Tree]
InterPro	IPR010218. NADH_DH_csu. IPR001268. NADH_UbQ_OxRdtase_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC_RICFE

Accession

Primary (citable) accession number: Q4UM07

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)