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Q4UM05

- NUOA_RICFE

UniProt

Q4UM05 - NUOA_RICFE

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Protein

NADH-quinone oxidoreductase subunit A

Gene
nuoA, RF_0567
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-581-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit A (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit A
NDH-1 subunit A
NUO1
Gene namesi
Name:nuoA
Ordered Locus Names:RF_0567
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Reviewed predictionAdd
BLAST
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123NADH-quinone oxidoreductase subunit AUniRule annotationPRO_0000271221Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi315456.RF_0567.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0838.
HOGENOMiHOG000100119.
KOiK00330.
OMAiSTYECGF.
OrthoDBiEOG6QVRQ6.

Family and domain databases

HAMAPiMF_01394. NDH1_NuoA.
InterProiIPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
PANTHERiPTHR11058. PTHR11058. 1 hit.
PfamiPF00507. Oxidored_q4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4UM05-1 [UniParc]FASTAAdd to Basket

« Hide

MLQNSELLQE YLPIAIFFGI ALLVSGLIMI LPNLLSTKKY NKDKLEPYEC    50
GFEPFSDARS KFDIRFYLVA ILFIIFDLEI AFLVPWAISL NMIGKIGFFS 100
MIFFLFVLTI GFIYEWKKGA LDW 123
Length:123
Mass (Da):14,309
Last modified:July 5, 2005 - v1
Checksum:i6D028874E4F29BA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61418.1.
RefSeqiWP_011270899.1. NC_007109.1.
YP_246583.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61418; AAY61418; RF_0567.
GeneIDi3400346.
KEGGirfe:RF_0567.
PATRICi17891685. VBIRicFel64634_0675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61418.1 .
RefSeqi WP_011270899.1. NC_007109.1.
YP_246583.1. NC_007109.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61418 ; AAY61418 ; RF_0567 .
GeneIDi 3400346.
KEGGi rfe:RF_0567.
PATRICi 17891685. VBIRicFel64634_0675.

Phylogenomic databases

eggNOGi COG0838.
HOGENOMi HOG000100119.
KOi K00330.
OMAi STYECGF.
OrthoDBi EOG6QVRQ6.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-581-MONOMER.

Family and domain databases

HAMAPi MF_01394. NDH1_NuoA.
InterProi IPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view ]
PANTHERi PTHR11058. PTHR11058. 1 hit.
Pfami PF00507. Oxidored_q4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiNUOA_RICFE
AccessioniPrimary (citable) accession number: Q4UM05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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