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Q4UM05

- NUOA_RICFE

UniProt

Q4UM05 - NUOA_RICFE

Protein

NADH-quinone oxidoreductase subunit A

Gene

nuoA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-581-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit AUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit AUniRule annotation
    NDH-1 subunit AUniRule annotation
    NUO1UniRule annotation
    Gene namesi
    Name:nuoAUniRule annotation
    Ordered Locus Names:RF_0567
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123NADH-quinone oxidoreductase subunit APRO_0000271221Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0567.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei68 – 8821HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 3 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0838.
    HOGENOMiHOG000100119.
    KOiK00330.
    OMAiSTYECGF.
    OrthoDBiEOG6QVRQ6.

    Family and domain databases

    HAMAPiMF_01394. NDH1_NuoA.
    InterProiIPR023043. NAD(P)H_OxRDtase_bac/plastid.
    IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
    [Graphical view]
    PANTHERiPTHR11058. PTHR11058. 1 hit.
    PfamiPF00507. Oxidored_q4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4UM05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQNSELLQE YLPIAIFFGI ALLVSGLIMI LPNLLSTKKY NKDKLEPYEC    50
    GFEPFSDARS KFDIRFYLVA ILFIIFDLEI AFLVPWAISL NMIGKIGFFS 100
    MIFFLFVLTI GFIYEWKKGA LDW 123
    Length:123
    Mass (Da):14,309
    Last modified:July 5, 2005 - v1
    Checksum:i6D028874E4F29BA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61418.1.
    RefSeqiWP_011270899.1. NC_007109.1.
    YP_246583.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61418; AAY61418; RF_0567.
    GeneIDi3400346.
    KEGGirfe:RF_0567.
    PATRICi17891685. VBIRicFel64634_0675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61418.1 .
    RefSeqi WP_011270899.1. NC_007109.1.
    YP_246583.1. NC_007109.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0567.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61418 ; AAY61418 ; RF_0567 .
    GeneIDi 3400346.
    KEGGi rfe:RF_0567.
    PATRICi 17891685. VBIRicFel64634_0675.

    Phylogenomic databases

    eggNOGi COG0838.
    HOGENOMi HOG000100119.
    KOi K00330.
    OMAi STYECGF.
    OrthoDBi EOG6QVRQ6.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-581-MONOMER.

    Family and domain databases

    HAMAPi MF_01394. NDH1_NuoA.
    InterProi IPR023043. NAD(P)H_OxRDtase_bac/plastid.
    IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
    [Graphical view ]
    PANTHERi PTHR11058. PTHR11058. 1 hit.
    Pfami PF00507. Oxidored_q4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiNUOA_RICFE
    AccessioniPrimary (citable) accession number: Q4UM05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3