ID   FABI_RICFE              Reviewed;         260 AA.
AC   Q4ULZ7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
DE            EC=1.3.1.9;
DE   AltName: Full=NADH-dependent enoyl-ACP reductase;
GN   Name=fabI; OrderedLocusNames=RF_0575;
OS   Rickettsia felis (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=42862;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD(+) = trans-
CC       2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. FabI subfamily.
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DR   EMBL; CP000053; AAY61426.1; -; Genomic_DNA.
DR   RefSeq; YP_246591.1; -.
DR   GeneID; 3401524; -.
DR   GenomeReviews; CP000053_GR; RF_0575.
DR   KEGG; rfe:RF_0575; -.
DR   NMPDR; fig|315456.3.peg.409; -.
DR   HOGENOM; Q4ULZ7; -.
DR   OMA; Q4ULZ7; LVHCLAF.
DR   BioCyc; RFEL315456:RF_0575-MON; -.
DR   BRENDA; 1.3.1.9; 297363.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NAD...; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   PANTHER; PTHR19410:SF12; Enoyl-ACP_rdct; 1.
DR   PRINTS; PR00081; GDHRDH.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Fatty acid biosynthesis; Lipid synthesis; Membrane; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    260       Enoyl-[acyl-carrier-protein] reductase
FT                                [NADH].
FT                                /FTId=PRO_0000286636.
FT   NP_BIND      12     38       NAD (By similarity).
FT   ACT_SITE    157    157       Proton acceptor (By similarity).
SQ   SEQUENCE   260 AA;  28254 MW;  14E5338B63ABDD2C CRC64;
     MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV KPLAEEIGCN
     FVSELDVTNP KSISNLFDDI KEKWGSFDFL LHGMAFADKN ELKGRYVDTS LENFHNSLHI
     SCYSLLELSR SAEALMHDGG SIVTLTYYGA EKVIPNYNVM GISKAALEAS VKYLATDLGE
     NNIRVNAISA GPIKTLASSA IGDFSTMLKS HAATAPLKRN TTQEDVGGAA VYLFSNLSKG
     VTGEIHYVDC GYNIMGSNKL
//