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Q4ULZ7 (FABI_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Short name=ENR
EC=1.3.1.9
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene names
Name:fabI
Ordered Locus Names:RF_0575
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.

Catalytic activity

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
PRO_0000286636

Regions

Nucleotide binding21 – 222NAD By similarity
Nucleotide binding66 – 672NAD By similarity
Nucleotide binding193 – 1975NAD By similarity

Sites

Active site1471Proton acceptor By similarity
Active site1571Proton acceptor By similarity
Binding site151NAD; via carbonyl oxygen By similarity
Binding site421NAD By similarity
Binding site941NAD; via carbonyl oxygen By similarity
Binding site971Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1641NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4ULZ7 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 14E5338B63ABDD2C

FASTA26028,254
        10         20         30         40         50         60 
MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV KPLAEEIGCN 

        70         80         90        100        110        120 
FVSELDVTNP KSISNLFDDI KEKWGSFDFL LHGMAFADKN ELKGRYVDTS LENFHNSLHI 

       130        140        150        160        170        180 
SCYSLLELSR SAEALMHDGG SIVTLTYYGA EKVIPNYNVM GISKAALEAS VKYLATDLGE 

       190        200        210        220        230        240 
NNIRVNAISA GPIKTLASSA IGDFSTMLKS HAATAPLKRN TTQEDVGGAA VYLFSNLSKG 

       250        260 
VTGEIHYVDC GYNIMGSNKL 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61426.1.
RefSeqYP_246591.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULZ7.
SMRQ4ULZ7. Positions 4-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0575.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61426; AAY61426; RF_0575.
GeneID3401524.
KEGGrfe:RF_0575.
PATRIC17891705. VBIRicFel64634_0684.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0623.
KOK00208.
OMAGILDMIH.
OrthoDBEOG6HF644.
ProtClustDBPRK06603.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-590-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSPR00081. GDHRDH.
ProtoNetSearch...

Entry information

Entry nameFABI_RICFE
AccessionPrimary (citable) accession number: Q4ULZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: January 22, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways