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Q4ULZ7

- FABI_RICFE

UniProt

Q4ULZ7 - FABI_RICFE

Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.By similarity

    Catalytic activityi

    An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151NAD; via carbonyl oxygenBy similarity
    Binding sitei42 – 421NADBy similarity
    Binding sitei94 – 941NAD; via carbonyl oxygenBy similarity
    Binding sitei97 – 971Substrate; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei147 – 1471Proton acceptorBy similarity
    Active sitei157 – 1571Proton acceptorBy similarity
    Binding sitei164 – 1641NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 222NADBy similarity
    Nucleotide bindingi66 – 672NADBy similarity
    Nucleotide bindingi193 – 1975NADBy similarity

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid elongation Source: UniProtKB
    2. protein homotetramerization Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-590-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
    Short name:
    ENR
    Alternative name(s):
    NADH-dependent enoyl-ACP reductase
    Gene namesi
    Name:fabI
    Ordered Locus Names:RF_0575
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000286636Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi315456.RF_0575.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULZ7.
    SMRiQ4ULZ7. Positions 4-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0623.
    KOiK00208.
    OMAiTGEIHHV.
    OrthoDBiEOG6HF644.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    Q4ULZ7-1 [UniParc]FASTAAdd to Basket

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    MTTGLLQGKK GLITGIANNM SISWAIAQLA KKHGAELWFT YQSEVLEKRV    50
    KPLAEEIGCN FVSELDVTNP KSISNLFDDI KEKWGSFDFL LHGMAFADKN 100
    ELKGRYVDTS LENFHNSLHI SCYSLLELSR SAEALMHDGG SIVTLTYYGA 150
    EKVIPNYNVM GISKAALEAS VKYLATDLGE NNIRVNAISA GPIKTLASSA 200
    IGDFSTMLKS HAATAPLKRN TTQEDVGGAA VYLFSNLSKG VTGEIHYVDC 250
    GYNIMGSNKL 260
    Length:260
    Mass (Da):28,254
    Last modified:July 5, 2005 - v1
    Checksum:i14E5338B63ABDD2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61426.1.
    RefSeqiYP_246591.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61426; AAY61426; RF_0575.
    GeneIDi3401524.
    KEGGirfe:RF_0575.
    PATRICi17891705. VBIRicFel64634_0684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61426.1 .
    RefSeqi YP_246591.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULZ7.
    SMRi Q4ULZ7. Positions 4-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61426 ; AAY61426 ; RF_0575 .
    GeneIDi 3401524.
    KEGGi rfe:RF_0575.
    PATRICi 17891705. VBIRicFel64634_0684.

    Phylogenomic databases

    eggNOGi COG0623.
    KOi K00208.
    OMAi TGEIHHV.
    OrthoDBi EOG6HF644.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci RFEL315456:GKEK-590-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiFABI_RICFE
    AccessioniPrimary (citable) accession number: Q4ULZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3