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Q4ULX9 (PYRG_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CTP synthase

EC=6.3.4.2
Alternative name(s):
CTP synthetase
UTP--ammonia ligase
Gene names
Name:pyrG
Ordered Locus Names:RF_0593
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen By similarity. HAMAP-Rule MF_01227

Catalytic activity

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate. HAMAP-Rule MF_01227

Enzyme regulation

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP By similarity. HAMAP-Rule MF_01227

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. HAMAP-Rule MF_01227

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01227

Sequence similarities

Belongs to the CTP synthase family.

Contains 1 glutamine amidotransferase type-1 domain.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' CTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

CTP synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537CTP synthase HAMAP-Rule MF_01227
PRO_0000266204

Regions

Domain290 – 536247Glutamine amidotransferase type-1
Region1 – 252252Aminator domain HAMAP-Rule MF_01227

Sites

Active site3791Nucleophile By similarity
Active site5091 By similarity
Active site5111 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4ULX9 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 93E3E8C22478B211

FASTA53760,523
        10         20         30         40         50         60 
MVRFIFVTGG VVSSLGKGLT AASLAMLLQA KGFKVCVRKL DPYLNVDPGT MNPHEHGEVY 

        70         80         90        100        110        120 
VTDDGAETDL DLGHYERFTG VSSCKFDSIT TGAIYSKLLK DERLGNYTGV TVQIIPHVTN 

       130        140        150        160        170        180 
IIKDFILSNT KGFDFIICEI GGTVGDIEGL PFFEAIRQIG NKLKNENCLF IHLTLLPYVK 

       190        200        210        220        230        240 
TARELKTKPT QHSVKELRAI GITPNILVCR AERNISKSEI DKIALFCNIE SEYVIPAIDQ 

       250        260        270        280        290        300 
KNIYLVPIAY HNSGLDNKVL KFFNINVVPS KLDKWYDIIG RLKDSSSKVR IAIIAKYHKL 

       310        320        330        340        350        360 
KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLNIDGILVP GGFGERATKG 

       370        380        390        400        410        420 
KITAITYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV TEEFKVDGTK IIEKINKNCE 

       430        440        450        460        470        480 
GSKITIENVK KTMRLGSYPC SLVANTIAAN AYKSLEINER HRHRYKFNNE FQNIFEKNGV 

       490        500        510        520        530 
VFSGFSKDEE IVEIIELPEL RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYTLRK 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61444.1.
RefSeqYP_246609.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULX9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0593.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61444; AAY61444; RF_0593.
GeneID3401542.
KEGGrfe:RF_0593.
PATRIC17891753. VBIRicFel64634_0708.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0504.
HOGENOMHOG000077515.
KOK01937.
OMAYEFNNAY.
OrthoDBEOG6RC3NR.
ProtClustDBPRK05380.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-608-MONOMER.
UniPathwayUPA00159; UER00277.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_01227. PyrG.
InterProIPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11550. PTHR11550. 1 hit.
PfamPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00337. PyrG. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRG_RICFE
AccessionPrimary (citable) accession number: Q4ULX9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways