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Q4ULX9

- PYRG_RICFE

UniProt

Q4ULX9 - PYRG_RICFE

Protein

CTP synthase

Gene

pyrG

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

    Catalytic activityi

    ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei379 – 3791NucleophileUniRule annotation
    Active sitei509 – 5091UniRule annotation
    Active sitei511 – 5111UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. CTP synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-608-MONOMER.
    UniPathwayiUPA00159; UER00277.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
    Alternative name(s):
    CTP synthetaseUniRule annotation
    UTP--ammonia ligaseUniRule annotation
    Gene namesi
    Name:pyrGUniRule annotation
    Ordered Locus Names:RF_0593
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537CTP synthasePRO_0000266204Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 536247Glutamine amidotransferase type-1UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 252252Aminator domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CTP synthase family.UniRule annotation
    Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG0504.
    HOGENOMiHOG000077515.
    KOiK01937.
    OMAiSVNIKYI.
    OrthoDBiEOG6RC3NR.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_01227. PyrG.
    InterProiIPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR11550. PTHR11550. 1 hit.
    PfamiPF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00337. PyrG. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ULX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRFIFVTGG VVSSLGKGLT AASLAMLLQA KGFKVCVRKL DPYLNVDPGT    50
    MNPHEHGEVY VTDDGAETDL DLGHYERFTG VSSCKFDSIT TGAIYSKLLK 100
    DERLGNYTGV TVQIIPHVTN IIKDFILSNT KGFDFIICEI GGTVGDIEGL 150
    PFFEAIRQIG NKLKNENCLF IHLTLLPYVK TARELKTKPT QHSVKELRAI 200
    GITPNILVCR AERNISKSEI DKIALFCNIE SEYVIPAIDQ KNIYLVPIAY 250
    HNSGLDNKVL KFFNINVVPS KLDKWYDIIG RLKDSSSKVR IAIIAKYHKL 300
    KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLNIDGILVP 350
    GGFGERATKG KITAITYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV 400
    TEEFKVDGTK IIEKINKNCE GSKITIENVK KTMRLGSYPC SLVANTIAAN 450
    AYKSLEINER HRHRYKFNNE FQNIFEKNGV VFSGFSKDEE IVEIIELPEL 500
    RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYTLRK 537
    Length:537
    Mass (Da):60,523
    Last modified:July 5, 2005 - v1
    Checksum:i93E3E8C22478B211
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61444.1.
    RefSeqiYP_246609.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61444; AAY61444; RF_0593.
    GeneIDi3401542.
    KEGGirfe:RF_0593.
    PATRICi17891753. VBIRicFel64634_0708.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61444.1 .
    RefSeqi YP_246609.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61444 ; AAY61444 ; RF_0593 .
    GeneIDi 3401542.
    KEGGi rfe:RF_0593.
    PATRICi 17891753. VBIRicFel64634_0708.

    Phylogenomic databases

    eggNOGi COG0504.
    HOGENOMi HOG000077515.
    KOi K01937.
    OMAi SVNIKYI.
    OrthoDBi EOG6RC3NR.

    Enzyme and pathway databases

    UniPathwayi UPA00159 ; UER00277 .
    BioCyci RFEL315456:GKEK-608-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_01227. PyrG.
    InterProi IPR029062. Class_I_gatase-like.
    IPR004468. CTP_synthase.
    IPR017456. CTP_synthase_N.
    IPR017926. GATASE.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR11550. PTHR11550. 1 hit.
    Pfami PF06418. CTP_synth_N. 1 hit.
    PF00117. GATase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00337. PyrG. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiPYRG_RICFE
    AccessioniPrimary (citable) accession number: Q4ULX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3