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Q4ULX9

- PYRG_RICFE

UniProt

Q4ULX9 - PYRG_RICFE

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Protein

CTP synthase

Gene

pyrG

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei379 – 3791NucleophileUniRule annotation
Active sitei509 – 5091UniRule annotation
Active sitei511 – 5111UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. CTP synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' CTP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-608-MONOMER.
UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
CTP synthetaseUniRule annotation
UTP--ammonia ligaseUniRule annotation
Gene namesi
Name:pyrGUniRule annotation
Ordered Locus Names:RF_0593
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537CTP synthasePRO_0000266204Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0593.

Structurei

3D structure databases

ProteinModelPortaliQ4ULX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 536247Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 252252Aminator domainAdd
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0504.
HOGENOMiHOG000077515.
KOiK01937.
OMAiSVNIKYI.
OrthoDBiEOG6RC3NR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ULX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRFIFVTGG VVSSLGKGLT AASLAMLLQA KGFKVCVRKL DPYLNVDPGT
60 70 80 90 100
MNPHEHGEVY VTDDGAETDL DLGHYERFTG VSSCKFDSIT TGAIYSKLLK
110 120 130 140 150
DERLGNYTGV TVQIIPHVTN IIKDFILSNT KGFDFIICEI GGTVGDIEGL
160 170 180 190 200
PFFEAIRQIG NKLKNENCLF IHLTLLPYVK TARELKTKPT QHSVKELRAI
210 220 230 240 250
GITPNILVCR AERNISKSEI DKIALFCNIE SEYVIPAIDQ KNIYLVPIAY
260 270 280 290 300
HNSGLDNKVL KFFNINVVPS KLDKWYDIIG RLKDSSSKVR IAIIAKYHKL
310 320 330 340 350
KDAYKSVIEA LDHAGIYYKY KIDLVWINAE NLTEENINKK LLNIDGILVP
360 370 380 390 400
GGFGERATKG KITAITYART NNIPFFGICF GMQLATIEIA QNLIGIKDAV
410 420 430 440 450
TEEFKVDGTK IIEKINKNCE GSKITIENVK KTMRLGSYPC SLVANTIAAN
460 470 480 490 500
AYKSLEINER HRHRYKFNNE FQNIFEKNGV VFSGFSKDEE IVEIIELPEL
510 520 530
RWFVGVQFHP EFKSKPFEAH PLFIQFIKAA IEYTLRK
Length:537
Mass (Da):60,523
Last modified:July 5, 2005 - v1
Checksum:i93E3E8C22478B211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61444.1.
RefSeqiYP_246609.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61444; AAY61444; RF_0593.
GeneIDi3401542.
KEGGirfe:RF_0593.
PATRICi17891753. VBIRicFel64634_0708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000053 Genomic DNA. Translation: AAY61444.1 .
RefSeqi YP_246609.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4ULX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 315456.RF_0593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61444 ; AAY61444 ; RF_0593 .
GeneIDi 3401542.
KEGGi rfe:RF_0593.
PATRICi 17891753. VBIRicFel64634_0708.

Phylogenomic databases

eggNOGi COG0504.
HOGENOMi HOG000077515.
KOi K01937.
OMAi SVNIKYI.
OrthoDBi EOG6RC3NR.

Enzyme and pathway databases

UniPathwayi UPA00159 ; UER00277 .
BioCyci RFEL315456:GKEK-608-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_01227. PyrG.
InterProi IPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR11550. PTHR11550. 1 hit.
Pfami PF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00337. PyrG. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiPYRG_RICFE
AccessioniPrimary (citable) accession number: Q4ULX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2005
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3