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Q4ULW8

- RUVA_RICFE

UniProt

Q4ULW8 - RUVA_RICFE

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Protein
Holliday junction ATP-dependent DNA helicase RuvA
Gene
ruvA, RF_0604
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. four-way junction helicase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. SOS response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRFEL315456:GKEK-621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvA (EC:3.6.4.12)
Gene namesi
Name:ruvA
Ordered Locus Names:RF_0604
OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Taxonomic identifieri315456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000008548: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. Holliday junction helicase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation
PRO_0000224902Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi315456.RF_0604.

Structurei

3D structure databases

ProteinModelPortaliQ4ULW8.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.

Phylogenomic databases

eggNOGiCOG0632.
HOGENOMiHOG000057115.
KOiK03550.
OMAiPEMVIDV.
OrthoDBiEOG679THG.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4ULW8-1 [UniParc]FASTAAdd to Basket

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MIGKLSGKID SQGDDYIIID VNGVGYLVYA SGKTLGKLAE GEFYKLFIET    50
HVREEHIHLY GFLTLEEKNF FNLLQSVNGI GTRMALSILS SLTPSDIQIA 100
INNEDKNIFK AISGVGAKLA ERIVLELKGK VAKISSGSVI IKDSLNIKNI 150
TPVASNEVIK ALVNLGFSRF EAQNAVQGII IQNPEISIDE LIKTALKNRN 200
AGL 203
Length:203
Mass (Da):22,102
Last modified:July 5, 2005 - v1
Checksum:iF124EEA3E52113DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61455.1.
RefSeqiYP_246620.1. NC_007109.1.

Genome annotation databases

EnsemblBacteriaiAAY61455; AAY61455; RF_0604.
GeneIDi3401121.
KEGGirfe:RF_0604.
PATRICi17891779. VBIRicFel64634_0719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000053 Genomic DNA. Translation: AAY61455.1 .
RefSeqi YP_246620.1. NC_007109.1.

3D structure databases

ProteinModelPortali Q4ULW8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 315456.RF_0604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY61455 ; AAY61455 ; RF_0604 .
GeneIDi 3401121.
KEGGi rfe:RF_0604.
PATRICi 17891779. VBIRicFel64634_0719.

Phylogenomic databases

eggNOGi COG0632.
HOGENOMi HOG000057115.
KOi K03550.
OMAi PEMVIDV.
OrthoDBi EOG679THG.

Enzyme and pathway databases

BioCyci RFEL315456:GKEK-621-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00031. DNA_helic_RuvA.
InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view ]
Pfami PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view ]
SMARTi SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00084. ruvA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
    Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
    PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-1525 / URRWXCal2.

Entry informationi

Entry nameiRUVA_RICFE
AccessioniPrimary (citable) accession number: Q4ULW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia felis (Rickettsia azadi)
    Rickettsia felis (strain URRWXCal2): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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