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Q4ULW8 (RUVA_RICFE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holliday junction ATP-dependent DNA helicase RuvA

EC=3.6.4.12
Gene names
Name:ruvA
Ordered Locus Names:RF_0604
OrganismRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) [Complete proteome] [HAMAP]
Taxonomic identifier315456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity. HAMAP-Rule MF_00031

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_00031

Subunit structure

Forms a complex with RuvB By similarity. HAMAP-Rule MF_00031

Sequence similarities

Belongs to the RuvA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Holliday junction ATP-dependent DNA helicase RuvA HAMAP-Rule MF_00031
PRO_0000224902

Sequences

Sequence LengthMass (Da)Tools
Q4ULW8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: F124EEA3E52113DC

FASTA20322,102
        10         20         30         40         50         60 
MIGKLSGKID SQGDDYIIID VNGVGYLVYA SGKTLGKLAE GEFYKLFIET HVREEHIHLY 

        70         80         90        100        110        120 
GFLTLEEKNF FNLLQSVNGI GTRMALSILS SLTPSDIQIA INNEDKNIFK AISGVGAKLA 

       130        140        150        160        170        180 
ERIVLELKGK VAKISSGSVI IKDSLNIKNI TPVASNEVIK ALVNLGFSRF EAQNAVQGII 

       190        200 
IQNPEISIDE LIKTALKNRN AGL 

« Hide

References

[1]"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-1525 / URRWXCal2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000053 Genomic DNA. Translation: AAY61455.1.
RefSeqYP_246620.1. NC_007109.1.

3D structure databases

ProteinModelPortalQ4ULW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING315456.RF_0604.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAY61455; AAY61455; RF_0604.
GeneID3401121.
KEGGrfe:RF_0604.
PATRIC17891779. VBIRicFel64634_0719.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0632.
HOGENOMHOG000057115.
KOK03550.
OMADVVPEMI.
OrthoDBEOG679THG.
ProtClustDBPRK00116.

Enzyme and pathway databases

BioCycRFEL315456:GKEK-621-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00031. DNA_helic_RuvA.
InterProIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00084. ruvA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVA_RICFE
AccessionPrimary (citable) accession number: Q4ULW8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia felis (Rickettsia azadi)

Rickettsia felis (strain URRWXCal2): entries and gene names