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Q4ULW8

- RUVA_RICFE

UniProt

Q4ULW8 - RUVA_RICFE

Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. four-way junction helicase activity Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. SOS response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRFEL315456:GKEK-621-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvAUniRule annotation
    Ordered Locus Names:RF_0604
    OrganismiRickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
    Taxonomic identifieri315456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000008548: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. Holliday junction helicase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Holliday junction ATP-dependent DNA helicase RuvAPRO_0000224902Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvB.UniRule annotation

    Protein-protein interaction databases

    STRINGi315456.RF_0604.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ULW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0632.
    HOGENOMiHOG000057115.
    KOiK03550.
    OMAiPEMVIDV.
    OrthoDBiEOG679THG.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00031. DNA_helic_RuvA.
    InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PfamiPF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view]
    SMARTiSM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00084. ruvA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4ULW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGKLSGKID SQGDDYIIID VNGVGYLVYA SGKTLGKLAE GEFYKLFIET    50
    HVREEHIHLY GFLTLEEKNF FNLLQSVNGI GTRMALSILS SLTPSDIQIA 100
    INNEDKNIFK AISGVGAKLA ERIVLELKGK VAKISSGSVI IKDSLNIKNI 150
    TPVASNEVIK ALVNLGFSRF EAQNAVQGII IQNPEISIDE LIKTALKNRN 200
    AGL 203
    Length:203
    Mass (Da):22,102
    Last modified:July 5, 2005 - v1
    Checksum:iF124EEA3E52113DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61455.1.
    RefSeqiYP_246620.1. NC_007109.1.

    Genome annotation databases

    EnsemblBacteriaiAAY61455; AAY61455; RF_0604.
    GeneIDi3401121.
    KEGGirfe:RF_0604.
    PATRICi17891779. VBIRicFel64634_0719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000053 Genomic DNA. Translation: AAY61455.1 .
    RefSeqi YP_246620.1. NC_007109.1.

    3D structure databases

    ProteinModelPortali Q4ULW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 315456.RF_0604.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAY61455 ; AAY61455 ; RF_0604 .
    GeneIDi 3401121.
    KEGGi rfe:RF_0604.
    PATRICi 17891779. VBIRicFel64634_0719.

    Phylogenomic databases

    eggNOGi COG0632.
    HOGENOMi HOG000057115.
    KOi K03550.
    OMAi PEMVIDV.
    OrthoDBi EOG679THG.

    Enzyme and pathway databases

    BioCyci RFEL315456:GKEK-621-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00031. DNA_helic_RuvA.
    InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    Pfami PF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00084. ruvA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite."
      Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.
      PLoS Biol. 3:1-12(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-1525 / URRWXCal2.

    Entry informationi

    Entry nameiRUVA_RICFE
    AccessioniPrimary (citable) accession number: Q4ULW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia felis (Rickettsia azadi)
      Rickettsia felis (strain URRWXCal2): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3